Biletskyy D. P., Ustiansky O. O., Tkach G. F., Sikora V. Z., Maksymova O. S.

MORPHOLOGY

Scentific article

Water is the basis of the internal environment. Water determines all life processes in organs and tissues, and is an integral part of metabolic processes. The water deficiency brings about the dysfunction or suspension of the synthetic, excretory, detoxification cell functions and the deterioration of functions in the organism. The parotid gland is one of the major salivary glands which performs many functions. The gland produces the largest amount of serous secretion compared with other large salivary glands. The violation of water-salt metabolism is one of the main factors that cause the development of salivary gland pathology. Thus, studying the morphological features of the parotid gland at dehydration and understanding its restorative capabilities will contribute to the acquisition of new knowledge for the diagnosis, prevention and treatment of salivary glands diseases in humans and animals. That is why, the purpose of our research is to study ultrastructural characteristics of the parotid gland alteration of mature rats under the influence of the general dehydration of the organism and the subsequent rehabilitation period. The experiment was carried out on 18 white laboratory male rats of the mature age. Drug studies were conducted using the transmission electron microscope. It was found that the greatest restorative possibilities in serous cells of the parotid salivary glands of mature rats occurred on the 28th day of rehabilitation, which were manifested as the increase in the number of lysosomes, decrease of dilatation of granular endoplasmic reticulum cisterns and tubules of the Golgi apparatus, increase in the electronic density of secretory granules, decrease in the area of serous cells cytoplasm by 10.59% (p = 0.0129), the area of serous cells nucleus – by 8.53% (p = 0.4506) and increase in the nuclear-cytoplasmic ratio by 2.78% (p = 0.7525).

mature rats, parotid salivary gland, ultrastructure, morphometry

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«Bulletin of problems biology and medicine» Issue 4 Part 3 (141), 2017 year, 289-292 pages, index UDK 616.316.5-018-053.8-092,9-06:616.395+612.392.3:611.316.018.086

10.29254/2077–4214–2017–4–3–141–289-292