THE ROLE OF MAST CELLS IN MAINTAINING HOMEOSTASIS OF THE COLON MUCOSA

  2. 2024
  3. THE ROLE OF MAST CELLS IN MAINTAINING HOMEOSTASIS OF THE COLON MUCOSA

Drozdovska S. B., Babak S. V., Lukyantseva H. V., Ilyin V. M., Skorobogatov A. M., Dubynska S. M., Sosnovski V. V.

THE ROLE OF MAST CELLS IN MAINTAINING HOMEOSTASIS OF THE COLON MUCOSA

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About the author:

Drozdovska S. B., Babak S. V., Lukyantseva H. V., Ilyin V. M., Skorobogatov A. M., Dubynska S. M., Sosnovski V. V.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The mucous membrane of the large intestine is a barrier that provides not only secretory, absorptive and excretory functions but also performs a protective function by reducing the entry of antigens into the body's internal environment. The issue of maintaining the homeostasis of the mucous membrane of the small and large intestines is currently one of the priority areas of morphological science. One of the key roles in this process is played by mast cells. Aim: to analyze and systematize modern scientific literature on the participation of mast cells in maintaining the homeostasis of the mucous membrane of the large intestine. Mast cells synthesize several biologically active substances (histamine, serotonin, leukotrienes, prostaglandins, heparin, etc.), which directly contribute to developing inflammatory, immune, and allergic reactions, secreting several biologically active substances. As structural and functional elements of loose connective tissue, mast cells are effector cells of the immune response. They provide optimal conditions for adequate microcirculation, modulate the sensitivity of the nerve endings of the intestinal mucosa, participate in the mechanisms of renewal of the intestinal epithelium, etc. Mast cells of the connective tissue of the large intestine take an active part in the mechanisms of maintaining tissue homeostasis due to participation in reactions of regulation of vascular tone, morphogenesis of cellular structures, initiation of immune responses and inflammatory processes, as well as processes of neuro-humoral regulation of intestinal function, etc. However, the information available in modern scientific literature regarding the role of mast cells in the functioning of the distal parts of the alimentary canal is still far from comprehensive knowledge, which actualizes the emergence of new research on this issue.

Tags:

colon, mast cells, mucous membrane

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 12-20 pages, index UDC 612.014.3:611.34

DOI:

10.29254/2077-4214-2024-1-172-12-20

2024 Issue 1, 172
colon mast cells mucous membrane
22.03.2024
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