Liubarets S. F., Liubarets T. F.

THE ROLE OF INDICATORS OF MINERAL METABOLISM IN THE DEVELOPMENT OF COMPLICATIONS OF TOOTH FORMATION DISORDERS IN CHILDREN

---

Show/Download

About the author:

Liubarets S. F., Liubarets T. F.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

In the spectrum of children's dental diseases, a significant share is made up of disorders of tooth formation. The imbalance of mineral metabolism, caused by various etiological factors, which occurs in the body as a whole, leads, in particular, to disturbances in the mineralization processes of the hard tissues of the teeth and the development of a number of complications, primarily caries. The aim is to analyze and summarize existing research on the role of indicators of mineral metabolism in the development of complications of tooth formation disorders in children as a basis for development and implementation of a complex of therapeutic and preventive measures with the use of modern means of remineralizing therapy. The development of caries in children as a complication of tooth formation due to an imbalance of mineral metabolism is the result of the influence of many factors, both general and local. Common factors include: the presence of somatic, endocrine, transferred infectious diseases, nutritional characteristics, etc. Local cariogenic factors include changes in the composition of saliva, in particular, an increase in the content of lactic and pyruvic acids in it, the activity of lactate dehydrogenase, the presence of pathogenic microflora in the oral cavity, etc. The influence of local factors leads to an increase in the processes of anaerobic glycolysis and oxidation. The combination of these processes with violations of mineralization processes, including calcium-phosphate metabolism, significantly increases the probability of dental caries in children as a complication of molar-incisor enamel hypomineralization, which is confirmed, in particular, enamel resistance test indicators. Conclusions. 1. Analysis of studies on the role of mineral metabolism indicators in the development of complications of tooth formation disorders indicates the prevalence of carious lesions due to the influence of general and local factors, in particular, insufficient mineralizing potential of blood serum and oral fluid. 2. The generalization of studies on the role of mineral exchange indicators in the development of complications of tooth formation disorders creates the basis for the development and implementation of a complex of therapeutic and preventive measures with the use of modern means of remineralizing therapy.

Tags:

Bibliography:

1. Ishutko IF. Vplyv khimichnykh elementiv na strukturu i vlastyvosti emali. Stomatoloh. 2014;2:31-37. Dostupno: http://www.C:/Users/user/ Downloads/ sonkp_2014_1_7%20(1). [in Ukrainian].
2. Kunin A, Evdokimova A, Moiseeva N. Age related differences of tooth enamel morphochemistry in health and dental caries. EPMA J. 2015;6(1):3.
3. Liubarets SF. Porushennia formuvannia zubiv ta yikh uskladnennia u ditei: diahnostyka, likuvannnia, profilaktyka [avtoref. dysertatsii]. Kyiv: Natsionalnyi medychnyi universytet imeni O. O. Bohomoltsia; 2019. 40 s. [in Ukrainian].
4. Labii YuA. Shliakhy pidvyshchennia rezystentnosti emali zubiv u ditei, khvorykh na systemnu hipoplaziiu emali, shcho prozhyvaiut v raionakh iz riznym antropohennym zabrudnenniam [avtoref. dysertatsii]. Iv. Frankivsk: Iv. Frankivskyi. nats. med. un-t; 2016. 15 s. [in Ukrainian].
5. Crombie F, Cochrane N, Manton D, Palamara J, Reynolds E. Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res. 2014;47(3):259-63.
6. Vasko LV, Kiptenko LI, Hortynska OM, Hryntsova NB. Histolohichna budova orhaniv rotovoi porozhnyny. Budova zubiv. Sumy: SumDU; 2016. 57 s. [in Ukrainian].
7. Sorochenko HV. Kliniko-eksperymentalne obhruntuvannia shliakhiv ta metodiv pidvyshchennia kariiesrezystentnosti emali postiinykh zubiv z riznym rivnem mineralizatsii [avtoref. dysertatsii]. Kyiv: Nats. med. un-t; 2017. 31 s. [in Ukrainian].
8. Kitazono CF, Mussolino de QA, Bezerra da SRA, Sawamura R, Bachmann L, Silva LAB, et al. Oral aspects in celiac disease children: clinical and dental enamel chemical evaluation. Academic Journal Jun. 2015;119(6):636-43.
9.  Sheshukova OV, Trufanova VP, Polishchuk TV. Nekariozni urazhennia zubiv (vydannia 2-e, dopovnene ta pereroblene). Poltava: Astraia; 2019. 154 s. [in Ukrainian].
10. Liubarets SF. Osoblyvosti zmin rezystentnosti emali postiinykh zubiv u ditei z porushenniamy yikh formuvannia. Visnyk problem biolohii i medytsyny. 2018;1(146):287-90. [in Ukrainian].
11. Katayoun S, Daryoush A, Morteza A. Prevalence and predictors of Molar Incisor Hypomineralization (MIH) among rural children in Northern Iran. Iran J Public Health. 2016;45(11):1528-30.
12. Liubarets SF, Kopylova OV, Belinhio TO, Kolbasynska VM, Siechyna IM, Liubarets TF. Hihiienichnyi stan porozhnyny rota, riven sIgA, mineralni skladovi rotovoi ridyny ta optymizatsiia profilaktychnykh zakhodiv u ditei z hipoplaziieiu emali zubiv na tli komorbidnoi patolohii. Problemy radiatsiinoi medytsyny ta radiobiolohii. 2015;20:125-35. [in Ukrainian].
13. Liubarets SF. Intensyvnist kariiesu u ditei z porushenniamy formuvannia zubiv, postrazhdalykh vnaslidok avarii na Chornobylskii AES. Problemy radiatsiinoi medytsyny ta radiobiolohii. 2021;26:326-36. DOI: 10/331145/2304-8336-2021-26-426-436. [in Ukrainian].
14. Afanasiev DIe, Liubarets SF. Odontolohichni efekty ionizuiuchoho vyprominiuvannia (ohliad). Problemy radiatsiinoi medytsyny ta radiobiolohii. 2020;25:18-55. DOI: 10/331145/2304-8336-2020-25-18-55. [in Ukrainian].
15. Melnyk VS, Horzov LF, Bilyshchuk LM. Profilaktyka stomatolohichnykh zakhvoriuvan. Uzhhorod : FOP Danylo S. I.; 2019. 136 s. [in Ukrainian].
16. Editors of Encyclopaedia Britannica. Saliva. Britannica; 2024. Available from: https://www.britannica.com/science/saliva.
17. Klitynska OO. Kompleksne obhruntuvannia rannoi diahnostyky, profilaktyky ta poetapnoho likuvannia kariiesu u ditei, yaki postiino prozhyvaiut v umovakh bioheokhimichnoho defitsytu ftoru ta yodu [avtoref. dysertatsii]. Poltava: Ukrainska med. stomat. akademiia; 2015. 38 s. [in Ukrainian].
18. Oktysiuk YuV, Rozhko MM. Osoblyvosti mikrokrystalizatsii rotovoi ridyny u ditei pry kariiesi zubiv iz vrakhuvanniam klimato-heohrafichnykh umov yikh prozhyvannia. Visnyk problem biolohii i medytsyny. 2014;2(111):374-8. [in Ukrainian].
19. Soviak OO. Osoblyvosti klinichnoho perebihu mnozhynnoho kariiesu zubiv ta obhruntuvannia likuvalno-profilaktychnykh zakhodiv u ditei shkilnoho viku [avtoref. dysertatsii]. Lviv: Lvivskyi nats. med. un-t; 2016. 21 s. [in Ukrainian].
20. Sharma A, Meenakshi B, Rama KV, Srinivasan V. Salivary levels of calcium and phosphorus in children with and without early childhood caries: A pilot study. SRM Journal of Research in Dental Sciences. 2019;11(2):72 DOI: 10.4103/srmjrds.srmjrds_5_20.
21. Pandey P, Reddy NV, Rao VAP, Saxena A, Chaudhary CP. Estimation of salivary flow rate, pH, buffer capacity, calcium, total protein content and total antioxidant capacity in relation to dental caries severity, age and gende. Contemp Clin Dent. 2015;6(1):65-71.
22. Bilous IV. Chynnyky ryzyku rozvytku ta shliakhy profilaktyky systemnoi hipoplazii emali zubiv u ditei [avtoref. dysertatsii]. Iv.-Frankivsk: Iv.- Frankivska derzh. med. akademiia; 2004. 21 s. [in Ukrainian].
23. Kulyhina VM, Pylypiuk OIu. Pokaznyky doslidzhennia shvydkosti slynovydilennia, рН rotovoi ridny i stanu kyslotno-luzhnoi rivnovahy v ditei z yuvenilnym revmatoidnym artrytom. Klinichna ta eksperymentalna patolohiia. 2015;14.1(51):84-8. [in Ukrainian].
24. Kulyhina VM, Pylypiuk OIu. Eksperymentalne doslidzhennia efektyvnosti zaproponovanoho metodu profilaktyky kariiesu zubiv na modeli adiuvantnoho artrytu u tvaryn. Visnyk morfolohii. 2015;21(1):44-9. [in Ukrainian].
25. Singh V, Arora R, Bhayya D, Singh D, Sarvaiya B, Mehta D. Comparison of relationship between salivary electrolyte levels and dental caries in children with Down syndrome. J Nat Sci Biol Med. 2015;6(1):144-8.
26. Abd Al Zaher Khalifa MA, Abouelkheir HM, Khodiyar SE, Mohammed GAM. Salivary composition and dental caries among children controlled asthmatics. Egyptian Journal of Chest Diseases and Tuberculosis. 2014;63(4):777-88.
27. Krynychnykh H, Shuvalov S, Pavlov V, Kulytska O, Nahaichuk V, Muntian M. Densytometrychnyi metod otsiniuvannia shchilnosti kistkovoi tkanyny frontalnoho viddilu verkhnoi shchelepy z prohnostychnoiu metoiu. Ukrainskyi stomatolohichnyi almanakh. 2023;3:44-48. [in Ukrainian].
28. Khalatbari H, Binkovitz LA, Parisi MT. Dual-energy X-ray absorptiometry bone densitometry in pediatrics: a practical review and update. Pediatr Radiol. 2021;5:25-39. DOI: 10.1007/s00247-020-04756-4.
29. Smoliar NI, Solonko HM. Osnovni pokaznyky kaltsii fosfornoho obminu u ditei z mnozhynnym kariiesom, yakym provodyly sanatsiiu pid zahalnym znebolenniam, ta yikhnia informatyvnist. Novyny stomatolohii. 2014;2(79):94-7. [in Ukrainian].
30. Durá Travé T, Gallinas Victoriano F. Dental caries in children and vitamin D deficiency: a narrative review. European Journal of Pediatrics. 2024;183:523-8. DOI: 10.1007/s00431-023-05331-3. [in Ukrainian].
31. Botelho J, Machado V, Proença L, Delgado AS, Mendes JJ. Vitamin D deficiency and oral health: a comprehensive review. Nutrients. 2020;12:1471.
32. Jha A, Jha S, Shree R, Kumar A, Menka K, Shrikaar M. Association between serum ferritin, hemoglobin, vitamin D3, serum albumin, calcium, thyrotropin-releasing hormone with early childhood caries: a case-control study. Int J Clin Pediatr Dent. 2021;14:648-51.
33. Williams TL, Boyle J, Mittermuller BA, Caroline Carrico C, Schroth RJ. Association between Vitamin D and dental caries in a sample of Canadian and American preschool-aged children. Nutrients. 2021;13:4465.
34. Dimova M, Dimitrova D. Study of the dietary minerals intake of children with early childhood caries. Archives of the Balkan Medical Union. 2019;54(3):540-8. DOI: 10.31688/ABMU.2019.54.3.21.
35. Castañeda-Sarmiento S, Uchima Koecklin K, Belen Barahona Hernandez M, Pereda Santos G, César Bruno Luyo J, César Sánchez Sotomayor J, et al. Association between developmental defects of enamel and early childhood caries in children under 6 years old: A systematic review and meta-analysis. Heliyon. 2022;8(9):10479. DOI: 10.1016/j.heliyon.2022.e10479.
36. Liubarets SF, Antamonov MIu. Kryterii prohnozuvannia vynyknennia kariiesu u ditei z hipoplaziieiu emali postiinykh zubiv z urakhuvanniam antropohennykh chynnykiv dovkillia. Environment and Health. 2018;4:32-5. [in Ukrainian].
37. Liubarets SF, Savychuk OV, Shapovalova HI. Retrospektyvnyi analiz karioznoho urazhennia tverdykh tkanyn zubiv u ditei z radiatsiino zabrudnenykh unaslidok avarii na Chornobylskii AES terytorii Ukrainy. Suchasna pediatriia. 2024;1(37):76-84. DOI: 10/15574/ SP/2024.137.76. [in Ukrainian].
38. Kril IA. Suchasnyi pohliad na likuvannia systemnoi hipoplazii emali zubiv ta profilaktyku yii uskladnennia kariiesom u ditei. Visnyk problem biolohii i medytsyny. 2017;3.1(137):57-60. DOI: 10.32402/ dovkil2018.04.032.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 54-63 pages, index UDC 612.126:616.314.9-002.4-071-08

DOI:

10.29254/2077-4214-2024-4-175-54-63