THE PARTICIPATION OF HUMORAL MECHANISMS IN THE REGULATION OF THE CONTRACTILE ACTIVITY OF SMOOTH MUSCLE TISSUE OF THE INTESTINE

  2. 2023
  3. THE PARTICIPATION OF HUMORAL MECHANISMS IN THE REGULATION OF THE CONTRACTILE ACTIVITY OF SMOOTH MUSCLE TISSUE OF THE INTESTINE

Oliinyk T. M., Rozova K. V., Kovalchuk O. I., Raskaliei T. Ya., Raskaliei V. B., Khmelnytska Yu. K.

THE PARTICIPATION OF HUMORAL MECHANISMS IN THE REGULATION OF THE CONTRACTILE ACTIVITY OF SMOOTH MUSCLE TISSUE OF THE INTESTINE

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About the author:

Oliinyk T. M., Rozova K. V., Kovalchuk O. I., Raskaliei T. Ya., Raskaliei V. B., Khmelnytska Yu. K.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The large intestine is the most distal part of the alimentary canal, the main function of which is to prepare undigested food residues for removal from the body and evacuate them to the outside. This is ensured by the implementation of the contractile function of the smooth muscle tissue of the intestinal wall, which is characterized by rhythmic phasic, tonic and high-amplitude propulsive contractions. The amplitude and frequency of these contractions are determined by the complex interaction of complex nervous, humoral and myogenic regulation mechanisms. Nervous effects on smooth muscle tissue are realized due to the implementation of metasympathetic enteric motor reflexes and innervation of extra-organ nerves. They add up with numerous and complex humoral effects. The stimulating effect on the motor function of the intestine is determined by the influence of purines and some regulatory peptides, and serotonergic and tachykininergic effects play a modulating role in this complex regulatory process. The final point of application of humoral effector effects is the secretion of acetylcholine by cholinergic excitatory motoneurons and the release of nitric oxide and vasoactive intestinal peptide. It is worth noting that, in addition to the above, a number of other endogenous biologically active substances (short-chain fatty acids, neurotrophic factors, sex hormones, histamine, prostaglandins, etc.) take part in the modulation of the contractile activity of the smooth muscle tissue of the colon. However, the deep nature of the mechanisms that exert regulatory effects on the contractile activity of the smooth muscles of the colon wall is still not sufficiently understood.

Tags:

contractile activity, motor function, regulation, smooth muscle tissue

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Publication of the article:

«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 42-47 pages, index UDC 612.36+616.008.3/5«312»

DOI:

10.29254/2077-4214-2023-4-171-42-47

2023 Issue 4, 171
contractile activity motor function regulation smooth muscle tissue
22.12.2023
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