Panchenko Yu. O., Mogilevskyy S. Yu.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Common diabetes complication is development of diabetic maculopathy (DMP) and macular edema (DME). Surgical treatment of DMP is accompanied by a macula structural improvement, but the functional results depend on the DME formation, the criterion of which is the increase of the central retina thickness (CRT). Aim. To investigate the frequency and significance of diabetic macular edema in the structure of recurrence in the surgical treatment of diabetic maculopathy in patients with type 2 diabetes. Object and methods. The study included 313 cases (313 eye) with DMP and initial (n=40), moderate or severe non-proliferative (n=92) and proliferative diabetic retinopathy (n=181). Patients received four types of treatment: closed subtotal vitrectomy (CSV; n=78); CSV with peeling of the internal limiting membrane (ILM) in the macular region (n=85); CSV, ILM peeling and a stage of panretinal laser coagulation of the retina (n=81) and in addition to all these interventions – a cataract phacoemulsification (n=69). For statistical processing of data was performed using the program Statistica 10 (StatSoft, Inc., USA). Results. The relapses of DMP in the 1 year after the operation amounted to 29.7% (93 eyes). The fate of the DME in the presence of DMP recurrence after 1 month was 37.5%, in 3 months – 80.7%, in 6 months – 84.4% and after 1 year – 88.5%. The frequency of DME of the difference between the applied methods was not (p=0,129). CRT after surgery (CRT0) and the severity of retinopathy on the ETDRS scale substantially influenced the development of DMP relapses (p<0.005). The critical CRT0 level, at which likely development of the DMP relapse after 1 year was more 356.0 µm (p=0.031); critical ETDRS more than 70 points (p=0.005) to predict relapses after 3, 6 months and 1 year follow-up. Conclusion. The incidence of DME in the relapsese of DMP surgical treatment during the 1 year of observation increased; on the relapses development was significantly influenced by the initial CRT and the value of bales of ETDRS

diabetic maculopathy, macular edema, diabetes mellitus type 2, surgical treatment, relapses

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«Bulletin of problems biology and medicine» Issue 3 (152), 2019 year, 171-177 pages, index UDK 616.735-005:617.735-0.02:616.379-008.64

10.29254/2077-4214-2019-3-152-171-177