Behosh I. B., Behosh N. B., Bakalets O. V.

THE IMPORTANCE OF ACTIVATING AND INHIBITORY SYSTEMS OF THE BRAIN IN THE REGULATION OF THE SLEEP-WAKE CYCLE

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Behosh I. B., Behosh N. B., Bakalets O. V.

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MODERN MEDICAL ACHIEVEMENTS

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Scientific article

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The central nervous system is a complex neuronal network and its function depends on the balance between excitatory and inhibitory neurons. The orexinergic system keeps the body awake. Among the wide range of vital functions regulated by orexins are sleep-wake cycles, emotional behavior and emotional memory, stress, attention, mood, cognitive function, and energy homeostasis. It has been established that various pathological conditions are based on the dysfunction of the orexinergic system. Changes in central and peripheral levels of orexin are associated with conditions such as anorexia nervosa, age-related cognitive decline, and neurodegenerative diseases. In addition, a selective loss of orexin neurons has been found in narcolepsy, which confirms the crucial role of orexins in maintaining wakefulness.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 63-65 pages, index UDC 618.8-009.836-071

DOI:

10.29254/2523-4110-2024-2-173/addition-63-65