SUBMICROSCOPIC CHANGES IN THE SENSORIMOTOR AREA OF THE CEREBRAL CORTEX UNDER THE CONDITIONS OF EXPERIMENTAL HYPERHOMOCYSTEINEMIA, HYPER- AND HYPOTHYREOSIS AND THEIR COMBINED INFLUENCE

  2. 2022
  3. SUBMICROSCOPIC CHANGES IN THE SENSORIMOTOR AREA OF THE CEREBRAL CORTEX UNDER THE CONDITIONS OF EXPERIMENTAL HYPERHOMOCYSTEINEMIA, HYPER- AND HYPOTHYREOSIS AND THEIR COMBINED INFLUENCE
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Publication of the article:

«Bulletin of problems biology and medicine», 2022 Issue 3, 166,

Nechiporuk V. M., Pentyuk L. O., Shushkovskaya Y. Y., Niushko T. Y., Korda M. M.

SUBMICROSCOPIC CHANGES IN THE SENSORIMOTOR AREA OF THE CEREBRAL CORTEX UNDER THE CONDITIONS OF EXPERIMENTAL HYPERHOMOCYSTEINEMIA, HYPER- AND HYPOTHYREOSIS AND THEIR COMBINED INFLUENCE

About the author:

Nechiporuk V. M., Pentyuk L. O., Shushkovskaya Y. Y., Niushko T. Y., Korda M. M.

Heading:

MORPHOLOGY

Type of article:

Scentific article

Annotation:

Thyroid hormones are fundamental to the development of the brain and ensure its functioning throughout life. Hyperhomocysteinemia (HHCy) has been shown to be an important risk factor for cerebrovascular disease leading to stroke, Alzheimer’s disease, and vascular dementia. Recent experimental studies have shown the effect of HHCy on cerebrovascular biology and the molecular mechanisms that explain these changes.The aim – to define the submicroscopic changes in the sensorimotor area of the cerebral cortex under influence of HHCy against the background of hyper- and hypothyroidism. Object and methods. HHCy was modeled by administering exogenous HCy to animals in the form of thiolactone at a dose of 100 mg/kg of body weight once a day for 28 days. Hyperthyroidism (intragastric L-thyroxine for 21 days 200 µg/kg*day), hypothyroidism (thiamazole 10 kg*day) for 21 days. Separate groups of animals were injected with L-thyroxine and thiamazole in parallel with HCy. Study results. HHCy was accompanied by destructively changed organelles, submicroscopic changes in astrocytic glia and blood capillaries. In turn, hyperthyroidism caused hypertrophy of mitochondria, a decrease in the number of ribosomes and destructive changes in hemocapillaries. The most significant alterative and degenerative changes in neurocytes of the cortex of the large hemispheres under conditions of hyperthyroidism and HHCy. Submicroscopically, the most profound violations of their ultrastructure were found in the neurons of animals that were modeled with HHCy and hypothyroidism compared to all previous experimental groups. Conclusions. Submicroscopic studies of the sensorimotor area of the cortex of the cerebral hemispheres of the experimental groups under conditions of simulated HHCy, hypo- and hyperthyroidism, and especially under conditions of their combined influence, established deep submicroscopic neurodegenerative changes in the cerebral cortex. Established neurodegenerative changes in cortical neurocytes occur against the background of neurovascular disorders and alteration of neuroglia.

Tags:

hyperthyroidism,hypothyroidism,hyperhomocysteinemia,cerebral cortex.

Bibliography:

 

  1. Bode H, Ivens B, Bschor T, Schwarzer G, Henssler J, Baethge C. Association of Hypothyroidism and Clinical Depression: A Systematic Review and Meta-analysis. JAMA Psychiatry. 2021 Dec 1;78(12):1375-1383. DOI: 10.1001/jamapsychiatry.2021.2506.
  2. Ritchie M, Yeap BB. Thyroid hormone: Influences on mood and cognition in adults. Maturitas. 2015 Jun;81(2):266-75. DOI: 10.1016/j. maturitas.2015.03. 016.
  3. Williams GR. Neurodevelopmental and neurophysiological actions of thyroid hormone. J Neuroendocrinol. 2008 Jun;20(6):784-94. DOI: 10.1111/j.1365-2826.2008.01733.x.
  4. Emoto N, Okazaki-Hada M, Yamaguchi Y, Okajima F, Goto R, Sugihara H. Risk Preferences, Rationality of Choices, and Willingness to Pay for Preventive Medicine in Patients with Graves’ Thyrotoxicosis. Patient Prefer Adherence. 2021 Sep 7;15:1971-1979. DOI: 10.2147/ PPA.S323472.
  5. Smith CD, Grondin R, LeMaster W, Martin B, Gold BT, Ain KB. Reversible cognitive, motor, and driving impairments in severe hypothyroidism. Thyroid. 2015 Jan;25(1):28-36. DOI: 10.1089/thy.2014.0371.
  6. Schreckenberger MF, Egle UT, Drecker S, Buchholz HG, Weber MM, Bartenstein P, et al. Positron emission tomography reveals correlations between brain metabolism and mood changes in hyperthyroidism. J Clin Endocrinol Metab. 2006 Dec;91(12):4786-91. DOI: 10.1210/jc.2006-0573.
  7. Miao Q, Zhang S, Guan YH, Ye HY, Zhang ZY, Zhang QY, et al. Reversible changes in brain glucose metabolism following thyroid function normalization in hyperthyroidism. AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):1034-42. DOI: 10.3174/ajnr.A2449.
  8. Göttlich M, Heldmann M, Göbel A, Dirk AL, Brabant G, Münte TF. Experimentally induced thyrotoxicosis leads to increased connectivity in temporal lobe structures: a resting state fMRI study. Psychoneuroendocrinology. 2015 Jun;56:100-9. DOI: 10.1016/j.psyneuen. 2015.03.009.
  9. Pilhatsch M, J Stamm T, Stahl P, Lewitzka U, Berghöfer A, Sauer C, et al. Treatment of bipolar depression with supraphysiologic doses of levothyroxine: a randomized, placebo-controlled study of comorbid anxiety symptoms. Int J Bipolar Disord. 2019 Oct 4;7(1):21. DOI: 10.1186/s40345-019-0155-y.
  10. Smith AD, Refsum H. Homocysteine, B Vitamins, and Cognitive Impairment. Annu Rev Nutr. 2016 Jul 17;36:211-39. DOI: 10.1146/annurevnutr-071715-050947.
  11. Janssen AW, de Leeuw FE, Janssen MC. Risk factors for ischemic stroke and transient ischemic attack in patients under age 50. J Thromb Thrombolysis. 2011 Jan;31(1):85-91. DOI: 10.1007/s11239-010-0491-3.
  12. Wang Q, Zhao J, Chang H, Liu X, Zhu R. Homocysteine and Folic Acid: Risk Factors for Alzheimer’s Disease-An Updated Meta-Analysis. Front Aging Neurosci. 2021 May 26;13:665114. DOI: 10.3389/fnagi.2021.665114.
  13. Safaei M, Akhondpoor Manteghi A, Shahini N, Mohammadpour AH. Comparison of serum levels of asymmetric dimethylarginine between patients who take two types of atypical anti psychotics. Med J Islam Repub Iran. 2019 Oct 23;33:114. DOI: 10.34171/mjiri.33.114.
  14. Kaye AD, Jeha GM, Pham AD, Fuller MC, Lerner ZI, Sibley GT, et al. Folic Acid Supplementation in Patients with Elevated Homocysteine Levels. Adv Ther. 2020 Oct;37(10):4149-4164. DOI: 10.1007/s12325-020-01474-z.
  15. Lauriola M, D’Onofrio G, Ciccone F, Germano C, Cascavilla L, Paris F, et al. Relationship of Homocysteine Plasma Levels with Mild Cognitive Impairment, Alzheimer’s Disease, Vascular Dementia, Psychobehavioral, and Functional Complications. J Alzheimers Dis. 2021;82(1):235-248. DOI: 10.3233/JAD-210166.
  16. Stangl GI, Weisse K, Dinger C, Hirche F, Brandsch C, Eder K. Homocysteine thiolactone-induced hyperhomocysteinemia does not alter concentrations of cholesterol and SREBP-2 target gene mRNAS in rats. Exp Biol Med (Maywood). 2007 Jan;232(1):81-7.
  17. Lin YH, Lin KH, Yeh CT. Thyroid Hormone in Hepatocellular Carcinoma: Cancer Risk, Growth Regulation, and Anticancer Drug Resistance. Front Med (Lausanne). 2020 May 22;7:174. DOI: 10.3389/fmed.2020.00174.
  18. Goralskiy LP, Homich VТ, Kononskiy ОІ. Osnovy histolohichnoi tekhniky i morfofunktsionalni metody doslidzhen u normi ta pry patolohii. Zhitomir: Polissya; 2011. 288 s. [in Ukrainian].
  19. Jakubowski H. Homocysteine Modification in Protein Structure/Function and Human Disease. Physiol Rev. 2019 Jan 1;99(1):555-604. DOI: 10.1152/physrev.00003.2018.
  20. Prieur EAK, Pjetri E, Zeisel SH, Jadavji NM. Reduced brain volume and impaired memory in betaine homocysteine S-methyltransferase knockout mice. Appl Physiol Nutr Metab. 2017 Nov;42(11):1228-1231. DOI: 10.1139/apnm-2017-0182.
  21. Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, et al. Homocysteine and Dementia: An International Consensus Statement. J Alzheimers Dis. 2018;62(2):561-570. DOI: 10.3233/JAD-171042.
  22. Mariani Wigley ILC, Mascheroni E, Peruzzo D, Giorda R, Bonichini S, Montirosso R. Neuroimaging and DNA Methylation: An Innovative Approach to Study the Effects of Early Life Stress on Developmental Plasticity. Front Psychol. 2021 May 17;12:672786. DOI: 10.3389/ fpsyg.2021.672786.
  23. Herrera AS, Ashraf GM, Del Carmen Arias Esparza M, Tarasov VV, Chubarev VN, Avila-Rodriguez MF, et al. Cerebrospinal Fluid, Brain Electrolytes Balance, and the Unsuspected Intrinsic Property of Melanin to Dissociate the Water Molecule. CNS Neurol Disord Drug Targets. 2018;17(10):743-756. DOI: 10.2174/1871527317666180904093430.
  24. Liu B, Wen L, Ran Q, Zhang S, Hu J, Gong M, et al. Dysregulation within the salience network and default mode network in hyperthyroid patients: a follow-up resting-state functional MRI study. Brain Imaging Behav. 2020 Feb;14(1):30-41. DOI: 10.1007/s11682-018-9961-6.
  25. Wijayabandara M, Appuhamy S, Weerathunga P, Chang T. Effective treatment of osmotic demyelination syndrome with plasmapheresis: a case report and review of the literature. J Med Case Rep. 2021 Jan 11;15(1):6. DOI: 10.1186/s13256-020-02573-9.
  26. Zhang Q, Bai Z, Gong Y, Liu X, Dai X, Wang S, et al. Monitoring glutamate levels in the posterior cingulate cortex of thyroid dysfunction patients with TE-averaged PRESS at 3T. Magn Reson Imaging. 2015 Jul;33(6):774-8. DOI: 10.1016/j.mri.2015.03.004.
  27. Zhang W, Liu X, Zhang Y, Song L, Hou J, Chen B, et al. Disrupted functional connectivity of the hippocampus in patients with hyperthyroidism: evidence from resting-state fMRI. Eur J Radiol. 2014 Oct;83(10):1907-13. DOI: 10.1016/j.ejrad.2014.07.003.
  28. Zecca C, Pasculli G, Tortelli R, Dell’Abate MT, Capozzo R, Barulli MR, et al. The Role of Age on Beta-Amyloid1-42 Plasma Levels in Healthy Subjects. Front Aging Neurosci. 2021 Aug 31;13:698571. DOI: 10.3389/fnagi.2021.698571.
  29. Quiroga C, Gatica D, Paredes F, Bravo R, Troncoso R, Pedrozo Z, et al. Herp depletion protects from protein aggregation by up-regulating autophagy. Biochim Biophys Acta. 2013 Dec;1833(12):3295-3305. DOI: 10.1016/j.bbamcr.2013.09.006.
  30. Wang TC, Chiu CJ, Chen PC, Chang TY, Tyler RS, Rojas-Roncancio E, et al. Increased Incidence of Tinnitus Following a Hyperthyroidism Diagnosis: A Population-Based Longitudinal Study. Front Endocrinol (Lausanne). 2021 Nov 3;12:741719. DOI: 10.3389/fendo.2021.741719.
  31. Moretti R, Giuffré M, Caruso P, Gazzin S, Tiribelli C. Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease. Int J Mol Sci. 2021 Feb 19;22(4):2051. DOI: 10.3390/ijms22042051.
  32. Petras M, Tatarkova Z, Kovalska M, Mokra D, Dobrota D, Lehotsky J, et al. Hyperhomocysteinemia as a risk factor for the neuronal system disorders. J Physiol Pharmacol. 2014 Feb;65(1):15-23.
  33. Minović I, Kieneker LM, Gansevoort RT, Eggersdorfer M, Touw DJ, Voerman AJ, et al. Vitamin B6, Inflammation, and Cardiovascular Outcome in a Population-Based Cohort: The Prevention of Renal and Vascular End-Stage Disease (PREVEND) Study. Nutrients. 2020 Sep 4;12(9):2711. DOI: 10.3390/nu12092711.
  34. Ploder M, Kurz K, Spittler A, Neurauter G, Roth E, Fuchs D. Early increase of plasma homocysteine in sepsis patients with poor outcome. Mol Med. 2010 Nov-Dec;16(11-12):498-504. DOI: 10.2119/molmed.2010.00008.
  35. Moretti R, Caruso P. The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice. Int J Mol Sci. 2019 Jan 8;20(1):231. DOI: 10.3390/ijms20010231.
  36. Leung KY, Pai YJ, Chen Q, Santos C, Calvani E, Sudiwala S, et al. Partitioning of One-Carbon Units in Folate and Methionine Metabolism Is Essential for Neural Tube Closure. Cell Rep. 2017 Nov 14;21(7):1795-1808. DOI: 10.1016/j.celrep.2017.10.072.
  37. Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, et al. Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood. 2006 Jan 15;107(2):591-3. DOI: 10.1182/blood-2005-06-2506.
  38. Zeng P, Shi Y, Wang XM, Lin L, Du YJ, Tang N, et al. Emodin Rescued Hyperhomocysteinemia-Induced Dementia and Alzheimer’s Disease-Like Features in Rats. Int J Neuropsychopharmacol. 2019 Jan 1;22(1):57-70. DOI: 10.1093/ijnp/pyy090.
  39. Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease. Nutr J. 2015 Jan 10;14:6. DOI: 10.1186/1475- 2891-14-6.

 

Publication of the article:

«Bulletin of problems biology and medicine» Issue 3 (166), 2022 year, 398-420 pages, index UDK Нечипорук В. М., Пентюк Л. О., Шушковська Ю. Ю., Нюшко Т. Ю., Корда М. М.

DOI:

10.29254/2077-4214-2022-3-166-398-420

2022 Issue 3, 166
05.02.2023
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