Shtroblia V. V., Lutsenko R. V.

STUDY OF ANTIOXIDANT ACTIVITY OF CARBON DIOXIDE GAS ON THE MODEL OF THE ACUTE INFLAMMATORY REACTION

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About the author:

Shtroblia V. V., Lutsenko R. V.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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Lipid peroxidation (LPO) is one of the leading causes of inflammation. Therefore, substances that correct it can be considered in the treatment of inflammatory processes. The aim is to establish the presence of carbon monoxide's antioxidant effect on the model of inflammatory reaction caused by formalin. In experiments on white rats of both sexes, the presence of antioxidant effect (effect on the content of TBA-AP, the activity of antioxidant (AO) enzymes catalase and superoxide dismutase (SOD) in carbon monoxide (0.5 ml) and in its combination with diclofenac (4 mg/kg) or chondroitin (3 mg/kg) was studied on a model of formalin inflammation. Rectal temperature was measured with an electronic thermometer 5 hours after the start of the experiment. Formalin-induced inflammation disrupted blood peroxidation processes, manifested by a significant increase in TBA-AP and catalase activity, and hyperthermia developed. Diclofenac, combined with carbon dioxide and chondroitin, did not significantly affect the lipid peroxidation processes and oxidative stress in the blood against the background of formalin-induced inflammation. Carbon dioxide or its combination with chondroitin significantly reduced the content of TBA-AP and catalase activity and, along with diclofenac, corrected the hyperthermic reaction in rats under conditions of experimental pathology. Carbon dioxide used prophylactically or therapeutically or in combination with chondroitin showed AO, reduced TBA-AP content, and catalase activity in the model of acute inflammation caused by formalin.

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 256-264 pages, index UDC 616-002.2:612.017-071

DOI:

10.29254/2077-4214-2024-1-172-256-264