Kobal I. V., Sokolenko V. L.

SIGNS OF IMMUNOSENESCENCE AT THE LEVEL OF THE LEUKOGRAM IN TEACHERS OF DIFFERENT AGES DURING THE PERIOD OF MARTIAL LAW

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About the author:

Kobal I. V., Sokolenko V. L.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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The study of the signs and mechanisms of immunosenescence is one of the current research areas of modern biology and medicine. Among the factors influencing the development of immunosenescence, psychological stress is indicated. Available studies show an increased level of stress among school teachers caused by martial law factors. The aim of the study is to determine the presence of changes in the leukocyte formula, as signs of immunosenescence, in education workers of different ages during martial law. The analysis of the leukocyte formula was carried out in 2023/2024. The control group was formed by students of 2-3 years of the Bohdan Khmelnytsky National University of Cherkasy (40 people). The research group was formed by 60 pedagogical workers of secondary education institutions of the city of Cherkasy and Cherkasy district, who under- went routine medical examinations. Within the groups, subgroups of the first mature age (26-34 years, 30 people) and the second mature age (35-52 years, 30 people) were distinguished. The studies were conducted in compliance with the rules of bioethics. Leukogram indicators were determined on the Diagon D-cell 60 analyzer (Diagon Ltd, Hungary). Additional analysis of granulocyte populations was performed using a blood smear stained according to Pappenheim. It was established that during the period of martial law, people working in the field of education show signs of stress, which are manifested by changes in the quantitative indicators of leukocyte populations and their ratio. Some of the stress-induced changes in natural resistance, especially pronounced among educators of the second mature age, are signs of mobilization of inflammatory processes and hypersensitivity reactions and can be characterized as primary markers of immunosenescence.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 140-148 pages, index UDC 612.66

DOI:

10.29254/2077-4214-2025-4-179-140-148