Neutrophils are characterized by high biological activity and have a great set of antibiotic proteins and hydrolases as alkaline and acidic, which is stored in granules of two types. When activated, neutrophils can dismiss the contents of granules and cytotoxic compounds into the extracellular space, where biological compounds and enzyme exercise antimicrobial protection. This mechanism underlies the pathogenesis of most diseases. An important role of neutrophils in phagocytosis installed. Despite significant progress in the study of the reactivity of neutrophils and the mechanisms underlying their jet responses, the ability of neutrophils and reactivity of anti-inflammatory compounds, it still remains an unexplored area of immunology. We studied the functional state of the reactive responses of polymorphonuclear neutrophilic granulocytes in the peripheral blood of children with visual impairments aged 10-16 years. To install reactive responses polymorphonuclear neutrophils (the largest population of immune cells) children aged 10-16 years with visual impairments conducted a study of peripheral blood 182 children. The children were divided into 3 groups, one of them, in the amount of 48 children constituted the control group comprised healthy children of secondary school № 12 in Slavic. To establish reactive responses polymorphonuclear neutrophils and the total immunological reactivity of the organism of children (boys and girls) with visual impairments aged 10-16 years, as well as in healthy children of appropriate age were taken whole blood, which smushes in a clean test tube with the anticoagulant EDTA-K2 2Н2О, which preserves the structure of white blood cells, red blood cells and prevents the accumulation of platelets. To count the elements of the peripheral blood and analysis of the results of the study used automatic Hematology analyzer series HB. Pathology of sight at children at the age of 10 16 years is accompanied by a decrease in the activity of nonspecific immune defense by 5.26% (P<0.05), which is associated with congestion in the immune response mcrophone system, the main population of immune cells (neutrophils) that exhibits positive reactivity by 31.75%, which also contributes to the current downward trend lymphocytic-granulocyte index, leukocyte and lymphocyte indices and tended to increase neutrophile-lymphocyte ratio, the index shift of leukocytes index ratio NG and monocytes, leukocytes, and erythrocyte sedimentation rate. Versatile all changes of indicators and degrees of violations of the reactive responses of NG. Carried out changes in the immuno-hematological indices, which characterize the level of reactive answers NG the peripheral blood of boys with visual impairments aged 10-16 years to reach mostly (91,67%) first-degree violations of the reactive response of neutrophils. The girls with visual impairments at the age of 10-16 years reduced reactive response. This is also evidenced by the decrease of the leukocyte index of 19.26%. But at the same time slightly increased activity level factors and general mechanisms of nonspecific reactivity of the organism of the girls from pathology of view. In addition, a trend towards reduction of index of shift of neutrophils, and a trend towards higher values of the index shift of leukocytes index ratio NG and monocytes, as well as a trend towards the increase of specific immunological reactivity, which is evidence of the adequacy of the specific immunological response of the organism. Boys with visual impairments, and girls of corresponding age values change immuno-hematological parameters that characterize the level of reactivity of the NG response in the peripheral blood, are largely (91,67%) first degree violations therefore, the main method of correction of reactive responses NG boys with visual impairments at the age of 10-16 years should be a method of rehabilitation of specially selected exercises physical education.
adolescents 10-16 years old, children with visual impairments, adaptive voltage, immunocompetent cells, cellular reactivity
«Bulletin of problems biology and medicine» Issue 1 (135), 2017 year, 398-402 pages, index UDK 616-092:617
