Herasymiuk I. Ye., Vakhnovska Kh. I.
PECULIARITIES OF THE MORPHOLOGICAL RECONSTRUCTION OF THE STRUCTURAL COMPONENTS OF THE KIDNEYS OF WHITE RATS AT DIFFERENT DEGREES OF GENERAL DEHYDRATION
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About the author:
Herasymiuk I. Ye., Vakhnovska Kh. I.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
An important component of homeostasis is the water-electrolyte balance. Disturbances in this balance can lead to a disruption of homeostasis with potentially fatal outcomes. The aim of this study was to identify the structural changes in the components of the renal parenchyma and the renal vasculature of white rats under varying degrees of total dehydration. Experiments were conducted on 36 adult male white rats, divided into two groups: a control group and an experimental group subjected to total dehydration by feeding them dry oats without access to water for 3, 6, and 10 days. For histological examination, kidney fragments were fixed in 10% neutral formalin solution and 96° alcohol. Paraffin sections 5-8 microns thick were stained with hematoxylin and eosin. The reactions of renal vessels during dehydration affect the structural organization of the kidney parenchyma. The intensity of these changes is directly dependent on the degree of total dehydration. Mild and moderate dehydration leads to increased wall tension and narrowing of the lumen in extra- and intra-organ segmental and arcuate arteries. Conversely, segmental arteries and arterioles tend to exhibit dilation reactions. As dehydration progresses, constriction reactions intensify in extra-organ and segmental arteries. In arcuate arteries, the functional state of smooth muscle layers inversely changes from constrictive to dilatory reactions. This further reduction in smooth muscle tone in segmental arteries and arterioles results in impaired renal corpuscle function due to decreased blood filling in their capillary glomeruli and dystrophic changes in renal tubule epithelium.
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Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 264-272 pages, index UDC 616.61-091:616.395]-092.9
