Steblovskyi D. V., Tkachenko P. I., Faustova M. O., Voloshyna L. I., Lychman V. O., Toropov O. A., Oliinichenko Ya. O.

PECULIARITIES OF THE MICROBIOTA IN ODONTOGENIC PHLEGMONS AGAINST THE BACKGROUND OF CARDIOVASCULAR DYSFUNCTION IN HUMANS

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Steblovskyi D. V., Tkachenko P. I., Faustova M. O., Voloshyna L. I., Lychman V. O., Toropov O. A., Oliinichenko Ya. O.

Heading:

DENTISTRY

Type of article:

Scientific article

Annotation:

Currently, the irrational and non-targeted use of antibiotics, particularly in patients with cardiovascular comorbidities, continues to contribute to the development of resistance in bacterial microbiota against antimicrobial agents. The aim of this study was to assess the spectrum of microorganisms most frequently isolated in odontogenic infections and to determine their antimicrobial susceptibility in the context of concurrent cardiologic pharmacotherapy. Microbiological samples were collected from 70 patients diagnosed with odontogenic phlegmon who received inpatient treatment at the Department of Maxillofacial Surgery, Poltava Regional Clinical Hospital. The selection criteria included individuals aged 30 to 50 years, regardless of the etiological source of infection. Among aerobic isolates, Streptococcus viridans predominated (61%), followed by Staphylococcus spp. (16%). Anaerobic flora was dominated by Prevotella spp. (41%), Peptostreptococcus spp. (28%), and Fusobacterium spp. (17%). Anaerobic Gram-negative bacteria comprised the largest proportion (40%), and two strains of Candida albicans were also detected. Streptococcus viridans showed high sensitivity to cefazolin (93%), amoxicillin (91%), and clindamycin (81%). Prevotella spp. were highly susceptible to cefazolin (95%) but less so to amoxicillin (67%). These findings confirm the predominance of Streptococcus viridans as a key pathogen in odontogenic phlegmons, although some studies report a higher prevalence of Gram-negative anaerobic rods. Our results also corroborate the role of Prevotella, Porphyromonas, and Fusobacterium species as predominant anaerobic pathogens isolated from purulent wounds in patients with odontogenic infections. Further multicenter investigations across various regions of Ukraine and Europe are warranted to improve the generalizability of these findings.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 551-557 pages, index UDC 579.61:616.314-002.3:616.1-092

DOI:

10.29254/2077-4214-2025-2-177-551-557