Lukyantseva H. V., Pastukhova V. A., Krasnova S. P., Oliinyk T.M., Luts Yu. P.

BIOLOGY

Scentific article

Abstract. The pancreatic hormone amylin is synthesized and secreted along with insulin in response to common stimuli. Amylin has numerous physiological effects, including a vasodilating effect in the mesenteric artery of rats, aswell as a stabilizing effect on the secretory function of mesenteric mast cells in animals, which may mediate improved microcirculation conditions and reduce the intensity of inflammation caused by burns of various etiologies. To test this hypothesis, we conducted experiments to determine the potential effect of amylin on the intensity of the inflammatory process caused by thermal and chemical burns in rats. Thermal burns in control animals resulted in a significant increase in the volume of the scorched paw, with the intensity of edema being greater 24 hours after thermal exposure than one hour. In contrast to control values, the volume of scalded paw in animals treated with amylin was significantly lower both one hour after the burn and one day. The method of chemical burns used in the second series of experiments by introducing a solution of acetic acid into the abdominal cavity of animals involves the development of peritonitis, which is accompanied by characteristic short-term changes in the posture of the animal (cramps). The frequency of convulsions reflects the intensity of the inflammatory process. Amylin significantly reduces the number of convulsions in animals compared with the control group. All the above allows us to conclude that under the influence of this hormone, the inflammatory process caused by chemical burns is realized less intensively compared to the control. The decrease in the intensity of inflammation under the influence of amylin indicates the presence of antiinflammatory action, which is realized due to its effect on various parts of the pathogenetic inflammatory process because thermal and chemical burns are of different etiological factors.

amylin, inflammation, thermal burn, chemical burn.

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«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 71-73 pages, index UDK 612.018:612.014.43+612.014.46(045)

10.29254/2077-4214-2021-2-160-71-73