Jha S. K., Andrić K.
PATHOGENESIS AND CURRENT APPROACHES TO THE TREATMENT OF PSORIASIS: A REVIEW OF RECENT RESEARCH AND CLINICAL GUIDELINES
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About the author:
Jha S. K., Andrić K.
Heading:
MODERN MEDICAL ACHIEVEMENTS
Type of article:
Scientific article
Annotation:
The article examines modern views on the pathogenesis of psoriasis, particularly the role of the immune system and inflammatory processes in developing this disease. Psoriasis is a complex autoimmune disease that requires a deep understanding of its occurrence and progression mechanisms to develop effective therapeutic approaches. The article provides a detailed analysis of current approaches to treating psoriasis, including traditional methods such as topical medications and phototherapy, and newer methods, including biological therapies targeting specific molecular targets in the immune system. The results of recent clinical studies demonstrating the effectiveness and safety of various treatment strategies are reviewed, and recommendations for their use in clinical practice are provided. Special attention is paid to innovative therapeutic approaches, such as inhibitors of cytokines that play a crucial role in inflammatory processes and prospects for gene therapy. Issues of long-term monitoring of patients, management of side effects and individualization of treatment taking into account the genetic and clinical characteristics of patients, are covered. The article provides a comprehensive overview of the current knowledge about psoriasis, which may be helpful for dermatologists, researchers and clinicians involved in treating this disease. She emphasizes the importance of a multifactorial approach to psoriasis therapy and the need for further research to improve treatment strategies and patients' quality of life.
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Bibliography:
- Fleming P. Tofacitinib: a new oral Janus kinase inhibitor for psoriasis. Br J Dermatol. 2019;180(1):13-14.
- Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk Factors for the Development of Psoriasis. Int J Mol Sci. 2019;20(18):4347.
- Keam SJ. Tapinarof Cream 1%: First Approval. Drugs. 2022;82(11):1221-1228.
- Papp K, Gordon K, Thaçi D, Morita A, Gooderham M, Foley P, et all. Phase 2 trial of selective tyrosine kinase 2 inhibition in psoriasis. N Engl J Med. 2018;379(14):1313-21.
- Wu JJ, Kavanaugh A, Lebwohl MG, Gniadecki R, Merola JF. Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis. J Eur Acad Dermatol Venereol. 2022;36(6):797-806.
- Zhang L, Guo L, Wang L, Jiang X. The efficacy and safety of tofacitinib, peficitinib, solcitinib, baricitinib, abrocitinib and deucravacitinib in plaque psoriasis - A network meta-analysis. J Eur Acad Dermatol Venereol. 2022;36(11):1937-1946.
- Amico S, Barnetche T, Dequidt L, Fauconneau A, Gerars E, Boursault L, et al. Characteristics of postinflammatory hyper- and hypopigmentation in patients with psoriasis: a survey study. J Am Acad Dermatol. 2020;83(4):1188-91.
- Kaufman BP, Alexis AF. Psoriasis in skin of color: insights into the epidemiology, clinical presentation, genetics, quality-of-life impact, and treatment of psoriasis in non-white racial/ethnic groups. Am J Clin Dermatol. 2018;19(3):405-423. Erratum in: Am J Clin Dermatol. 2018;19(3):425.
- Yan D, Afifi L, Jeon C, Cordoro KM, Liao W. A cross-sectional study of the distribution of psoriasis subtypes in different ethno-racial groups. Dermatol Online J. 2018;24(7):13030/qt5z21q4k2.
- Hoegler KM, John AM, Handler MZ, Schwartz RA. Generalized pustular psoriasis: a review and update on treatment. J Eur Acad Dermatol Venereol. 2018;32:1645-1651.
- Twelves S, Mostafa A, Dand N, Burri E, Farkas K, Wilson R. Clinical and genetic differences between pustular psoriasis subtypes. J Allergy Clin Immunol. 2019;143:1021-1026.
- Yemchenko YaO, Kaydashev IP, Ishcheykin KYe, Bezeha OV, Vasylyeva KV, Oliinichenko YaO, et al. Thiazolidinediones in the treatment of psoriasis in patients with obesity. World of Medicine and Biology. 2023;2(84):65-68.
- Yemchenko YaO, Kaydashev IP, Ishcheykin KYe, Bezeha OV, Vasylyeva KV, Oliinichenko YaO, et al. Correlation analysis of circadian rhythm with severity of psoriasis and obesity. World of Medicine and Biology. 2023;1(83):68-72.
Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 55-58 pages, index UDC 616.517
