Lukyantseva H. V., Pastukhova V. A., Oliinyk T. M., Khmelnytska Yu. K., Luts Yu. P.

LITERATURE REVIEWS

Scentific article

The problem of the possibility of influencing the progression of the systemic response of the body to burn injury remains unresolved, despite the active study of this problem. The question of participation of endogenous biologically active substances in pathogenetic reactions of a burn disease acquires special urgency in this sense. One such compound is the polypeptide hormone amylin. It is a normal physiological product of secretion of β-cells of the islets of Langerhans of the pancreas and diffuse secretory cells of the gastrointestinal tract. It serves as one of the endogenous regulators of maintaining homeostasis of the gastric mucosa, along with insulin and glucagon is involved in the regulation of carbohydrate metabolism. Analysis of the scientific literature has identified several possible mechanisms by which amylin can mediate its involvement in the implementation of anti-inflammatory and other effects of burn injury. The pancreatic hormone amylin potently reduces the reactivity of mast cells in vitro, both basal and in response to stimulants of acetylcholine and bradykinin, which may be one of the potential mechanisms of its anti-inflammatory action in burn injuries. Amylin also has vasodilating properties. It significantly enhances the contractile activity of blood and lymphatic microvessels. The pronounced vasodilating effect of amylin, as well as the strengthening of the contractile activity of lymphatic vessels contributes to the improvement of trophism and increases the regenerative capacity of tissues affected by burns. Reducing the intensity of inflammatory processes due to the influence of amylin reduces the degree of tissue edema, and also contributes to the leaching of toxic substances from the lesion. The participation of the pancreatic hormone amylin in the implementation of the systemic response to burn injury is anti-inflammatory effect, improving tissue nutrition, increasing the excretion of cell lysis products, as well as enhancing the regeneration of burnt tissues and organs.

thermal burn, chemical burn, amylin.

1. Protsenko OS, Shapoval OV, Teslenko HO, Rodionov MO, Voshchylin BR, Yeletskyi MS. Klinichni ta eksperymentalni doslidzhennia tkanyn pry termichnykh poshkodzhenniakh. Aktualni problemy suchasnoi medytsyny. 2019;3:4-13. DOI: 10.26565/2617-409X-2019-3-01. [in Ukrainian].
2. Zhernov OA, Kozynets HP, Kitri M, Huz OO. Obhruntuvannia khirurhichnoho likuvannia pisliaopikovykh deformatsii ta kontraktur z vykorystanniam roztiahnutykh obiednanykh klaptiv na osnovi kliuchovykh ta perforantnykh sudyn. Plastychna, rekonstruktyvna i estetychna khirurhiia. 2018;1-2:61-70. [in Ukrainian].
3. Sorokina OYu, Filip ZhV. Porivnialna kharakterystyka dynamiky pokaznykiv metabolichnoi vidpovidi u fazy perebihu opikovoi khvoroby zalezhno vid terminiv pochatku operatyvnoho likuvannia. Klinichna medytsyna. 2017;18(XXIII):42-9. [in Ukrainian].
4. Tejiram S, Romanowski KS, Palmieri TL. Initial management of severe burn injury. Curr Opin Crit Care. 2019 Dec;25(6):647-52. DOI: 10.1097/MCC. 0000000000000662.
5. Naot D, Musson DS, Cornish J. The Activity of Peptides of the Calcitonin Family in Bone. Physiol Rev. 2019 Jan 1;99(1):781-805.
6. Akter R, Cao P, Noor H, Ridgway Z, Tu LH, Wang H, et al. Islet amyloid polypeptide: Structure, function, and pathophysiology. J. Diabetes Res. 2016;2016:2798269. DOI: 10.1155/2016/2798269.2.
7. Lukyantseva HV, Pastukhova VA, Krasnova SP, Oliinyk TM, Luts YuP. Osoblyvosti vplyvu amilinu na intensyvnist zapalnykh protsesiv, sprychynenykh termichnym ta khimichnym opikom. Visnyk problem biolohii i medytsyny, 2021;2(160):71-3. DOI: 10.29254/2077-4214- 2021-2-160-71-73. [in Ukrainian].
8. Bower RL, Yule L, Rees TA, Deganutti G, Hendrikse ER, Harris PW, et al. Molecular Signature for Receptor Engagement in the Metabolic Peptide Hormone Amylin. ACS Pharmacol Transl Sci. 2018 Apr 23;1(1):32-49. DOI: 10.1021/acsptsci.8b00002.
9. Volkov VN. Novye pankreaticheskie gormony: amylin. Universum: Мedicina I pharmakologiya: elektron. nauchn. zhurnal. 2014;11(12):1- 23. [in Russian].
10. Hay DL, Chen S, Lutz TA, Parkes DG, Roth JD. Amylin: Pharmacology, Physiology, and Clinical Potential. Pharmacol Rev. 2015;67(3):564- 600. DOI: 10.1124/pr.115.010629.
11. Moreno P, Acitores A, Gutiérrez-Rojas I, Nuche-Berenguer B, El Assar M, Rodriguez ML, et al. Amylin effect in extrapancreatic tissues participating in glucose homeostasis, in normal, insulin-resistant and type 2 diabetic state. Peptides. 2017;32(10):2077-85.
12. Camilleri M. Gastrointestinal hormones and regulation of gastric emptying. Curr Opin Endocrinol Diabetes Obes. 2019;26(1):3-10. DOI: 10.1097/MED. 0000000000000448.
13. Kumar AP, Lee S, Lukman S. Computational and Experimental Approaches to Design Inhibitors of Amylin Aggregation. Curr Drug Targets. 2019;20(16):1680-1694.
14. Lutz ТА. The interaction of amylin with other hormones in the control of eating. Diabetes Obes Metab. 2013;15(2):99-111. DOI: 10.1111/ j.1463-1326. 2012.01670.x.
15. Mietlicki-Baase EG, Reiner DJ, Cone JJ, Olivos DR, McGrath LE, Zimmer DJ, et al. Amylin modulates the mesolimbic dopamine system to control energy balance. Neuropsychopharmacology. 2015;40(2):372-85. DOI: 10.1038/npp. 2014.180.
16. Nahaichuk VI, Khimich SD, Zheliba MD, Zhuchenko OP, Povoroznyk AM, Prysiazhniuk MB, et al. Suchasni tekhnolohii likuvannia khvorykh z krytychnymy ta nadkrytychnymy opikamy. Visnyk Vinnytskoho natsionalnoho medychnoho universytetu. 2017;2(21):428-33. [in Ukrainian].
17. Raietska YaB. Pokaznyky endohennoi intoksykatsii pry eksperymentalnii opikovii khvorobi v stadii toksemii. Biolohichni systemy. 2016;8(1):24-7. [in Ukrainian].
18. Nebesna ZM, Volkov KS, Lisnychuk NIe, Demkiv IIa. Zminy okysno-vidnovnykh reaktsii u tkanyni lehen za umov opikovoi travmy ta pry yii korektsii iz zastosuvanniam liofilizovanoho ksenodermoimplantata y ekzohennoho preparatu surfaktantu. Medychna ta klinichna khimiia. 2015;17(3):29-33. [in Ukrainian].
19. Komi DE, Khomtchouk K, Luke Santa PM. A Review of the Contribution of Mast Cells in Wound Healing: Involved Molecular and Cellular Mechanisms. Clin Rev Allergy Immunol. 2020 Jun;58(3):298-312. DOI: 10.1007/s12016-019-08729-w.
20. Komi DE, Wohrl S, Bielory L. Mast Cell Biology at Molecular Level: a Comprehensive Review Clin Rev Allergy Immunol. 2020 Jun;58(3):342- 365. DOI: 10.1007/s12016-019-08769-2.
21. Jiménez M, Cervantes-Garcia D, Cordova-Davalos LE, Perez-Rodriguez MJ, Gonzalez-Espinosa C, Salinas E. Responses of Mast Cells to Pathogens: Beneficial and Detrimental Roles. Front Immunol. 2021 Jun 15;12:685865. DOI: 10.3389/fimmu.2021.685865.
22. Zhang Z, Kurashima Y. Two Sides of the Coin: Mast Cells as a Key Regulator of Allergy and Acute/Chronic Inflammation. Cells. 2021 Jun 28;10(7):1615. DOI: 10.3390/cells10071615.
23. Lukyantseva HV, Slobodian OM. Morfofunktsionalni protsesy v krovonosnykh sudynakh i spoluchnii tkanyni bryzhi shchuriv pislia vplyvu pankreatychnoho hormonu amilinu. Klinichna anatomiia ta operatyvna khirurhiia. 2019;18(3):13-17. [in Ukrainian].
24. Lukyantseva HV, Kopylova GN, Pastukhova VA, Belikova MV, Zinevich YV. Vliyanie amilina na bazalny I stimulirovannuyu sekretornuyu aktivnost tuchnyh kletok. Ukrainsky morphologichny almanah. 2013;11(2):64-6. [in Ukranian].
25. Lukyantseva HV, Sergeev IY, Pastukhova VA, Gunina LM. Dinamika sokratitelnoi aktivnosti izolirovannogo koltsevogo preparata aorty krys pod vliyaniem amilina. Ukrainsky morphologichnyi almanah. 2013;11(1):77-8. [in Russian].
26. Samonina GE, Kopylova GN, Lukjanzeva GV, Zhuykova SE, Smirnova EA, German SV, et al. Antiulcer effects of amylin: a review. Pathophysiology. 2004;11(1):1-6. DOI: 10.1016/j.pathophys.2003.10.008.

«Bulletin of problems biology and medicine» Issue 3 (161), 2021 year, 61-64 pages, index UDK 616-092:577.175.7+616-001.17

10.29254/2077-4214-2021-3-161-61-64