Ilenko-Lobach N. V., Boychenko O. M., Ilenko N. M.

ORAL CAVITY PATHOLOGY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (LITERATURE REVIEW)

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Ilenko-Lobach N. V., Boychenko O. M., Ilenko N. M.

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LITERATURE REVIEWS

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Scientific article

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Systemic lupus erythematosus (SLE), Liebman-Sachs disease, lupus is a diffuse autoimmune disease that affects connective tissue and its derivatives, microcirculatory vessels. It can also affect any internal organs and systems. In this disease, the human immune system produces antibodies that damage healthy cells. Systemic lupus erythematosus is an autoimmune disease caused by a combination of various genetic, epigenetic and environmental factors. The information presented in this publication corresponds to the last 10 years. 350 articles were reviewed and analyzed according to the inclusion and exclusion criteria to update different types of studies, so only 27 articles met these requirements. According to the diagnostic criteria of the American College of Rheumatology (ACR, 1982), there are currently 11 features of definitive lupus. The aim was to analyze scientific sources and describe and define the most up-to-date concepts of the disease symptoms and manifestations of the disease in the oral cavity. Lupus is a better-known immunologic disorder today with serious multisystemic consequences that are even more severe and develop more rapidly at an early age. Changes in the oral cavity secondary to SLE should be considered when performing dental procedures. It is advisable to consult with internists and immunologists, eliminate sources of infection and conduct follow-up to improve the patient's oral health. The involvement of a dentist is significant for the early detection of SLE, as skin and mucosal manifestations are the first to appear. It should be noted that there are important clinical considerations before any treatment, including changes in the joints, salivary glands and multiple organ failure, so it is necessary to know the various differential diagnoses to unambiguously identify the disease.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 20-27 pages, index UDC 616.31:616.5-002.525.2

DOI:

10.29254/2077-4214-2025-1-176-20-27