Svitailo V. S., Chemych M. D.

NDICATORS OF BLOOD COAGULATION FUNCTION, CONCENTRATION OF ENDOTHELIN-1 AND LONG-COVID

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About the author:

Svitailo V. S., Chemych M. D.

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CLINICAL AND EXPERIMENTAL MEDICINE

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Scientific article

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To assess the coagulation function in patients with Long-COVID, coagulation and Endothelin-1 as a biological marker of endothelial damage were determined in 77 patients with COVID-19 (study group) and 68 healthy individuals who did not have coronavirus disease (comparison group). Blood clotting parameters were within normal limits in both groups. The subjects showed a prolongation of prothrombin time, a decrease in the prothrombin index, and an increase in the international normalized ratio compared to similar indicators of healthy individuals. In the period of 3-6 months after the disease, these changes were significantly more pronounced than in the group as a whole. The activated partial thromboplastin time was generally lower in the convalescents, but in the period of 3-6 months after COVID-19, on the contrary, it was higher than in the comparison group. Endothelin-1 levels were significantly higher in those with coronavirus disease, and this difference was even greater in the 3-6 month period. The level of indicators did not depend on the presence of complaints indicative of Long-COVID. The above changes indicate a prolonged inflammatory process in patients with Long-COVID, accompanied by endothelial damage, activation of the “external” pathway of blood coagulation and an increased risk of thrombosis.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 3, 174, 180-186 pages, index UDC 616.98:578.834:616.151-008.815

DOI:

10.29254/2077-4214-2024-3-174-180-186