Baybakov V. M., Ostrovska S. S., Muntyan S. O., Khobotova N. V., Eismund P. A., Alekseenko V. V., Sribnyk P. L.
MORPHOMETRIC CORRELATION ANALYSIS OF TESTICLE DRAINAGE SYSTEMS IN THE PATHOGENESIS OF MALE INFERTILITY IN CHILDREN'S SURGICAL DISEASES OF THE TESTICLE IN THE HISTORY
Show/Download
About the author:
Baybakov V. M., Ostrovska S. S., Muntyan S. O., Khobotova N. V., Eismund P. A., Alekseenko V. V., Sribnyk P. L.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
The formation of principles underlying the organization of the morphofunctional features of the testicular drain age system, as well as the structures of the male reproductive system, represents an important area for further clinical and morphological studies aimed at clarifying the pathogenesis of male infertility. In the present study, data obtained from puncture biopsy of the testes in infertile men who had undergone surgical intervention on this organ during childhood were analyzed. During the structural morphometric correlation analysis conducted to determine the main causes of this pathology, the diseases were conditionally divided into cluster groups, which had characteris tic identification features depending on the degree of dysfunction of the testicular drainage systems. Morphometric analysis of correlation relationships confirmed a close association between indicators reflecting the state of the sper matogenic epithelium and the vessels of the microcirculatory bed of the testicular drainage systems. Knowledge of the long-term reproductive outcomes of the testis after childhood surgeries for cryptorchidism, varicocele, disorders of obliteration of the processus vaginalis of the peritoneum, and inflammatory diseases of the testis in these patho logical conditions remains fragmented and insufficiently comprehensive. The study demonstrated that in children who underwent surgical interventions for testicular diseases, significant disturbances occur in the vascular system of the testis, leading to a gradual decline in fertile function and the development of infertility. Recent advances in the study of the arterial, venous, and lymphatic vascular beds, as well as the efferent pathways of the testis, have made it possible to expand current understanding of certain aspects of the pathogenesis of male infertility and to clarify specific issues related to the morphofunctional state of the testicular drainage systems.
Tags:
Bibliography:
- Anjamrooz SH, Azari H, Abedinzadeh M. Abnormal patterns of the renal veins. Anat. Cell Biol. 2022;45(1):57-61.
- Choi WS, Kim SW. Current Issues in Varicocele Management: a Review. World. J. Mens. Health. 2023;31(1):12-20.
- Luo DY, Yang G, Liu JJ. Effects of varicocele on testosterone, apoptosis and expression of StAR mRNA in rat Leydig cells. Asian. J. Androl. 2021;13(2):287-291.
- Liu G, Yu F, Dai DZ. Endoplasmic reticulum stress mediating down regulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine. J. Biomed. Sci. 2022;19(1):4.
- Goldstein M, Schlegel PN. Surgical and medical management of male infertility. Cambridge: Cambridge University Press; 2023. 351 p.
- Mehta A, Goldstein M. Microsurgical varicocelectomy: a review. Asian Journal of Andrology. 2023;15:56-60.
- Farias JG, Puebla M, Acevedo A. Oxidative stress in rat testis and epididymis under intermittent hypobaric hypoxia: protective role of ascorbate supplementation. Journal of Andrology. 2020;31(3):314-321.
- Shiraishi K, Matsuyama H, Takihara H. Pathophysiology of varicocele in the male infertility in the era of assisted reproductive technology. International Journal of Urology. 2022;19:538-550.
- Ho CH, Yang SS, Tsai YC. Minilaparoscopic high-ligation with the processus vaginalis undissected and left in situ is a safe, effective, and durable treatment for pediatric hydrocele. Urology. 2022;76:134-137.
- Sozubir S, Ekingen G, Senel UA. Continuous debate on contralateral processus vaginalis: evaluation technique and approach to patency. Hernia. 2023;10(1):74-78.
- Wang JH, Zhang W, Tou JF. Incidence of Pediatric Metachronous Contralateral Inguinal Hernia in Children Aged Year ≥ 1year. World Journal of Pediatrics. 2022;8:256-259.
- Zavras N, Christou A, Misiakos E. Current Trends in the Management of Inguinal Hernia in Children. International Journal of Clinical Medicine. 2023;5:770-777.
Publication of the article:
«Bulletin of problems biology and medicine», 2026 Issue 1, 180, 409-417 pages, index UDC 616.697-092:576.31
