Hnatjuk M. S., Hdanska N. Ja., Tatarchuk L. V., Monastyrska N. Ja.

MORPHOLOGY

Scentific article

It is known that the remodeling of the chambers of the heart can be caused by various changes in hemodynamics in the great and small circles of blood circulation and the system of the hepatic portal vein. It should be noted that the remodeling of the heart chambers in postresection portal hypertension has not been studied enough. The purpose of research to study the features of spatial changes of the chambers of the heart at the removal of different volumes of the liver parenchyma. Methods and Material. Peculiarities of spatial changes of heart chambers of 95 laboratory adult white male rats, which were divided into 3 groups, were studied. The 1 group included 30 intact animals, the 2 – 32 rats in which the left lateral lobe of the liver was removed (31.5% of its parenchyma), the 3 – 33 experimental animals in which resection of the left and right lateral lobes was performed (58.1% of the liver parenchyma). Surgical interventions were performed under thiopental anesthesia in accordance with the rules of asepsis and antiseptics. Euthanasia of animals was performed by bloodletting under conditions of thiopental anesthesia. Planimetry and volumetric measurements of heart chambers were performed. The endocardial surface area of the left and right ventricles, the planimetric index, the area of the left and right atria, the planimetric index of the atria, the afferent, external and reserve volumes of the ventricles were determined. Histological micropreparations were made from heart chambers. Quantitative indicators were processed statistically. Results and Discussion. It was found that hemodynamic disorders in postresection portal hypertension affected hemodynamics in the great circle of blood circulation and changes in the spatial characteristics of the heart chambers. Thus, the area of the endocardial surface of the left ventricle at the same time increased by 25.8%, and the right – by 30.7% (p<0.001), the planimetric index decreased by 3.7 %. The area of the endocardial surface of the left atrium increased by 25.6%, the right – by 20.4% (p<0.001), the planimetric index – by 4.3% (p<0.05). In the conditions of postresection portal hypertension, the inflow volume of the left ventricle increased by 29.9%, the outflow volume – by 68.0% (p<0.001), the reserve volume decreased by 8.7%. In the right ventricle, these volumes changed by 24.8%, 88.6% (p<0.001) and 6.2%, respectively. Thus, resection of the left and right lateral lobes of the liver leads to the development of postresection portal hypertension, in which there is an uneven, disproportionate expansion of the heart chambers, growth of the fetal and external and reduced reserve volumes of the ventricles. The most pronounced decrease in reserve volume was found in the left ventricle.

resection of the liver, postresection portal hypertension, chambers of the heart, remodeling.

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«Bulletin of problems biology and medicine» Issue 3 (161), 2021 year, 249-252 pages, index UDK 616.36-089.87-06.616-91]-092.9

10.29254/2077-4214-2021-3-161-249-252