Shatorna V. F., Tymchuk K. M.
MORPHOLOGICAL CHANGES IN THE STRUCTURE OF THE SMALL INTESTINE WALL OF PREGNANT FEMALE RATS UNDER THE INFLUENCE OF CHRONIC ADMINISTRATION OF CADMIUM CHLORIDE AND COPPER SUCCINATE
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About the author:
Shatorna V. F., Tymchuk K. M.
Heading:
BIOLOGY
Type of article:
Scientific article
Annotation:
Anthropogenic pollution of the environment with heavy metals is becoming one of the top threats to living organisms, including humans, and economic and technological progress is increasingly disrupting natural ecosystems. The accumulation of heavy metals can change the structure of proteins, adversely affect metabolism, cause cellular mutations, disrupt the structure and permeability of cell membranes, and cause malfunctioning of internal organs. Today, it is essential to determine the impact of heavy metal compounds on the body in case of their constant (chronic) intake and accumulation in the body. There are various ways in which heavy metals enter the body; when entering through the gastrointestinal tract, cadmium absorption is, on average, up to 5%, with changes in the composition of the intestinal flora and the intestinal mucosa. The experiment aimed to determine morphological changes in the structures of the small intestine of female rats under chronic isolated exposure to cadmium salts at a dose of 2.0 mg/kg and in combination with copper succinate at a dose of 0.1 mg/kg under conditions of enteral administration. Study period: 13th and 19th day of administration. Chronic intragastric administration of cadmium chloride at a dose of 2.0 mg/kg leads to a significant thinning of the villi of the small intestine and mucous membrane. The combined administration of cadmium with copper succinate restores the diameter of the villi to the control values. Exposure to cadmium chloride increases the number of goblet cells in the mucous membrane of the small intestinal villi at both study periods, and the combined administration of cadmium and copper restores the number of goblet cells to the control values. The results of the study reveal the bioantagonistic nature of copper succinate to the action of cadmium chloride on the structure of the small intestine and prove that copper succinate is a potential antagonist of cadmium chloride in the indicated dose and method of administration in the rat experiment.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 116-125 pages, index UDC 611.013:616.341-092.9:546.48
