Slobodian R. V.
MORPHOLOGICAL ASSESSMENT OF THE APPLICATION OF HYDROGELS FOR THE LOCAL TREATMENT OF INFLAMMATORY WOUNDS IN AN EXPERIMENT
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About the author:
Slobodian R. V.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
Studying changes in the morphological picture with modelled purulent inflammatory diseases is an urgent scientific task. The main advantages of hydrogel bandages are absolute sterility from the moment of their manufacture, sorption properties, biocompatibility, a slight effect of desensitisation due to cooling of the wound surface, elasticity, atraumaticity during replacement, and transparency. For this study, we used hydrogel bandages saturated with silver ions and an antioxidant drug. The study aimed to investigate the morphological picture of the wound healing process in the experiment using hydrogel bandages saturated with silver ions and an antioxidant drug. The experiment was performed on 80 male rats. Animals were withdrawn from the experiment on days 3, 7, 10, 14. Weigert staining was used to identify elastic fibres. Trichrome-Mason stain was used to detect muscle tissue and collagen fibres. Magnification was x40 and x100. There were no differences in wound morphology on the third day in the control, first, and second experimental groups. There were signs of angiogenesis in the third group on the third day. During this period, the formation of elastic fibres was noted. An early onset of granulation tissue formation was noted in the third group. On the seventh day, there were signs of fibroplasia. On the 10th day, the wound edges were epithelialised, and a scar with fibroblast and fibrocyte dominance was observed in the superficial layers, while in the depths, there was a significant accumulation of collagen, indicating an early onset of regeneration from the dermis. The elastic framework of the scar was fully formed on the 14th day of healing. Thus, it can be argued that reparative changes develop faster and more fully in the wounds of animals treated with local effects of hydrogel bandages saturated with silver ions and an antioxidant drug.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2023 Issue 4, 171, 366-376 pages, index UDC 616-001.4-002-085.262.1-018-092.9
