Pykaliuk V. S., Slobodian O. M., Antoniuk O. P., Lavreniuk V. E., Aponchuk L. S.

MORPHOLOGICAL ASPECTS OF THE ENDOCRINE FUNCTION OF THE HEART

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About the author:

Pykaliuk V. S., Slobodian O. M., Antoniuk O. P., Lavreniuk V. E., Aponchuk L. S.

Heading:

PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

Annotation:

In this article, the authors discuss the endocrine function of the heart, which is an important component of the coordination of integrated body systems and thus plays an important role in fluid, electrolyte and hemodynamic homeostasis. Studies of atrial and brain natriuretic peptides indicate that changes in cardiac endocrine function may explain the pathophysiology of cardiovascular diseases and, in particular, heart failure, in which several target organs develop resistance to the biological effects of cardiac natriuretic peptides. The products of cardiac endocrine function play an important role in physiological and pathological cardiovascular conditions, actively interacting with extracardiac hormonal systems.

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Bibliography:

1. Goetze JP, Bruneau BG, Ramos HR, Ogawa T, de Bold MK, de Bold AJ. Cardiac natriuretic peptides. Nat Rev Cardiol 2020;17:698-717. DOI: https://doi.org/10.1038/s41569-020-0381-0.
2. Mezzasoma L, Talesa VN, Romani R, Bellezza I. ANP and BNP Exert Anti-Inflammatory Action via NPR-1/cGMP Axis by Interfering with Canonical, Non-Canonical, and Alternative Routes of Inflammasome Activation in Human THP1 Cells. Int J Mol Sci. 2021;22(1):24. DOI: 10.3390/ijms22010024.
3. Clerico A, Zaninotto M, Passino C, Plebani M. New issues on measurement of B-type natriuretic peptides. Clin Chem Lab Med. 2017;56(1):32-39. DOI: 10.1515/cclm-2017-0433.
4. Sudoh T, Kangawa K, Minamino N, Matsuo H. A new natriuretic peptide in porcine brain. Nature. 1988;332:78-81. DOI: 10.1038/332078a0.
5. Wang T, Liu J, McDonald C, Lupino K, Zhai X, Wilkins BJ, et al. GDF15 is a heart-derived hormone that regulates body growth. EMBO Mol Med. 2017;9:1150-1164. DOI: 10.15252/emmm.201707604.
6. Kuwahara K, Nakagawa Y, Nishikimi T. Cutting Edge of Brain Natriuretic Peptide (BNP) Research - The Diversity of BNP Immunoreactivity and Its Clinical Relevance. Circ J. 2018;82(10):2455-2461. DOI: 10.1253/circj.CJ-18-0824.
7. Prickett TC, Pearson JF, Troughton RW, Kennedy MA, Espiner EA. The Predictive Value of A, B, and C-Type Natriuretic Peptides in People at Risk of Heart Disease: Protocol for a Longitudinal Observational Study. JMIR Res Protoc. 2023;12:e37011. DOI: 10.2196/37011.
8. Singh A, Kumar A, Hai Ah A, Masihullah M, Tripathy N, Singh PK. Serum B-type natriuretic peptide levels (BNP) can be used as a predictor of complications in patients undergoing non-cardiac surgery: a prospective observational study. Open Heart. 2023;10(1):e002256. DOI: 10.1136/openhrt-2023-002256.
9. Ogawa T, de Bold AJ. The heart as an endocrine organ. Endocrine connections. 2014;3(2):31-44. DOI: 10.1530/EC-14-0012.
10. Xie H, Huo Y, Chen Q, Hou X. Application of B-Type Natriuretic Peptide in Neonatal Diseases. Front Pediatr. 2021;9:767173. DOI: 10.3389/ fped.2021.767173.
11. Khaki Z, Nooshirvani P, Shirani D, Masoudifard M. Diagnostic value of atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP) and their correlation with lipoproteins in dogs with myxomatous mitral valve disease. BMC Vet Res. 2022;18:448. DOI: 10.1186/s12917- 022-03548-2.
12. Reginauld ShH, Cannone V, Iyer S, Scott Ch, Baily K, Schaefer J, et al. Differential regulation of ANP and BNP in acute decompensated heart failure - deficiency of ANP. JACC Heart Fail. 2019;7(10):891-898. DOI: 10.1016/j.jchf.2019.05.012.
13. Volpe M, Gallo G, Rubattu S. Endocrine functions of the heart: from bench to bedside. European Heart Journal. 2023;44(8):643-655. DOI: https://doi.org/10.1093/eurheartj/ehac759.
14. Sarzani R, Allevi M, Di Pentima Ch, Schiavi P, Spannella F, Giulietti F. Role of Cardiac Natriuretic Peptides in Heart Structure and Function. Int J Mol Sci. 2022;23(22):14415. DOI: 10.3390/ijms232214415.
15. Kuwahara K. The natriuretic peptide system in heart failure: Diagnostic and therapeutic implications. Pharmacol Ther. 2021;227:107863. DOI: 10.1016/j.pharmthera.2021.107863.
16. Semenov AG, Feygina EE. Standardization of BNP and NT-proBNP Immunoassays in Light of the Diverse and Complex Nature of Circulating BNP-Related Peptides Review Adv Clin Chem. 2018;85:1-30. DOI: 10.1016/bs.acc.2018.02.001.
17. Nishikimi T, Nakagawa Y. B-Type Natriuretic Peptide (BNP) Revisited – Is BNP Still a Biomarker for Heart Failure in the Angiotensin Receptor/Neprilysin Inhibitor Era? Biology (Basel). 2022;11(7):1034. DOI: 10.3390/biology11071034.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, addition, 39-41 pages, index UDC 612.17

DOI:

10.29254/2523-4110-2024-2-173/addition-39-41