Uvaiev B. S., Dymar N. M., Kondaurova G. Yu., Rytikova N. V., Grabovyi O. M., Yaremenko L. M.

MORPHO-FUNCTIONAL STATE OF CONVOLUTED SEMINIFEROUS TUBULES IN RATS UNDER THE INFLUENCE OF BIGUANIDE AND CLOSTILBEGIT

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About the author:

Uvaiev B. S., Dymar N. M., Kondaurova G. Yu., Rytikova N. V., Grabovyi O. M., Yaremenko L. M.

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PROSPECTS FOR THE DEVELOPMENT OF MORPHOLOGICAL AND CLINICAL RESEARCH

Type of article:

Scientific article

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The aim of the work was to investigate the morpho-functional state of the convoluted seminiferous tubules of rat testes under conditions of 6-week exposure to metformin, clomiphene and their combination. The experiment was conducted on 20 sexually mature rats, randomized into four groups: intact (I), metformin group (MET), clomiphene group (CLO) and combined group (MET+CLO). The drugs were administered orally in the form of solutions for 6 weeks. After the experiment, the testes were removed for histological and morphometric analysis. The area and perimeter of the convoluted seminiferous tubules, as well as the number of mitotically active cells, were determined on histological sections stained with hematoxylin-eosin. After conducting morphometric analysis, the results of the study indicate a multidirectional effect of metformin and clomiphene on the structure and functional state of the convoluted seminiferous tubules, as well as the absence of an enhancing effect when they are used simultaneously. The obtained data may be important for further study of pharmacological interactions of drugs that affect the male reproductive system.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, addition, 64-67 pages, index UDC 611.631.44:57.044:57.085

DOI:

10.29254/2523-4110-2025-4-179/addition-64-67