Kravchuk Y. S., Korda M. M.

MODULATING EFFECT OF MOLECULAR HYDROGEN ON THE GLYCEMIC PROFILE IN RATS WITH METABOLIC SYNDROME

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About the author:

Kravchuk Y. S., Korda M. M.

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CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

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Metabolic syndrome (MS) is a complex metabolic disorder in which carbohydrate metabolism disorders and insulin resistance play an important role in its pathogenesis. Molecular hydrogen is considered a promising modulator of metabolic processes, capable of influencing carbohydrate metabolism and the body's adaptive responses. The aim of the study was to evaluate the effect of water enriched with molecular hydrogen on carbohydrate metabolism parameters in rats with experimentally induced MS. The MS model was reproduced by prolonged feeding of a high-calorie diet. Some of the animals received water containing 0.6 ppm hydrogen. Blood serum glucose, insulin, HOMA-IR index, fructosamine, and glycated hemoglobin levels were determined; assessments were performed after 6, 12, and 20 weeks. Rats with MS showed a progressive increase in glucose, insulin, and HOMA-IR, reflecting increased insulin resistance, as well as an increase in fructosamine and HbA1c in the later stages of the experiment. The use of hydrogen-enriched water was stage-dependent. In the early period (6 weeks), no corrective effect was observed. At week 12, a moderate decrease in insulin and HOMA-IR was recorded. The most significant changes were observed at week 20: a decrease in glucose, insulin, HOMA-IR, and HbA1c concentrations compared to uncorrected animals, indicating a reduction in insulin resistance and partial stabilization of metabolic status. Thus, long-term use of molecular hydrogen contributes to a moderate improvement in carbohydrate metabolism and a reduction in insulin resistance in MS, although it does not completely normalize metabolic disorders. The results confirm the potential of molecular hydrogen as an auxiliary metabolic modulator.

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 148-159 pages, index UDC 577.1:612.015.3:616-056.52:591.3

DOI:

10.29254/2077-4214-2025-4-179-148-159