Koptev M. M., Bilash S. M., Pronina O. M., Sydorenko A. H., Kokovska O. V., Pirog-Zakaznikova A. V., Oliinichenko Ya. О.

LITERATURE REVIEWS

Scentific article

Nowadays, the issue of finding and choosing new effective, and most significantly, safe methods of prevention and treatment of stress disorders is one of the most principal tasks for modern medical science. Among stress-protective drugs, researchers recently have started to note Quercetin – plant-based drug, which possesses powerful antioxidant action. Quercetin is flavonol, which contains in many products of the diet (broccoli, onion, tea, berries and citrus fruits). In above mentioned plants, Quercetin is mostly found in the form of glycoside, isoquercetin, rutin and hyperin, which protect the plant from oxidative damage. The polyphenolic nature of Quercetin allows it to recapture free radicals; it is widely known as phytochemical substance, which also has medicinal properties. Positive effects by Quercetin prescription are observed during the treatment of neurodegenerative disorders, such as Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease. Flavanoid Quercetin can be proposed as a drug, which protects liver cells HepG2 from oxidative stress, connected with hyperglycemia. During the treatment of rheumatoid arthritis, methothrexate isthe first-line agent, but its intake is accompanied by numerous side effects. Parallel Quecetin prescription significantly enhances anti-inflammatory effect of the therapy, and also reduces hepatotoxic influence of methothrexate (p <0,05). Quercetin, along with such substances of plant origin, such as Perillyl Alcohol, and Berberine improves right ventricular disorders that occur in rats on the background of experimental pulmonary hypertension, by decreasing inflammation, apoptosis, and fibrosis; antioxidant-oxidant correlation increases. Sedum dendroidum infusion, which contains Quercetin and other polyphenols (flavonol glycosides, myricetin, kaempferol) promotes gastroprotection in models of an acute gastric ulcer. Also, anti-inflammatory influence of Quercetin has been determined, which is due the inhibition of interleukin-6 secretion by human lung fibroblasts. Under the conditions of hypoxia, the effectiveness of Quercetin for the prevention of oxidation of pulmonary surfactant is even higher than in Sulbatamol. Due to its antioxidant properties, it has become appropriate to prescribe Quercetin in the complex treatment of lung cancer. Besides, Quercetin has antitumoral action, because it is able toregulate the expression PPAR-γ in human lung cancer cells A549. To enhance therapeutic effect, combined strategy is proposed, when Quercetin and Curcumin are combined. The analysis of scientific literature determines that high antioxidant property of Quercetin has been proved by modern investigationsthat makesit a promising agent for the prevention, correction, and treatment of morphological and functional changes, which occur in the body against the background of stress.

stress, quercetin, correction.

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«Bulletin of problems biology and medicine» Issue 3 (161), 2021 year, 57-61 pages, index UDK [613.86+612.8]:161-08

10.29254/2077-4214-2021-3-161-57-61