MODERN REACTIVE ARTHRITIS IN CHILDREN. VIEWS ON THE PROBLEM

  2. 2024
  3. MODERN REACTIVE ARTHRITIS IN CHILDREN. VIEWS ON THE PROBLEM

Koniushevska A. A., Vaizer N. V., Kuzevanova M. V., Gerasymenko V. V., Gerasymenko K. О.

MODERN REACTIVE ARTHRITIS IN CHILDREN. VIEWS ON THE PROBLEM

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About the author:

Koniushevska A. A., Vaizer N. V., Kuzevanova M. V., Gerasymenko V. V., Gerasymenko K. О.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The problem of reactive arthritis (ReA) is one of the most challenging in both adult and paediatric rheumatology, as many issues remain unclear. The initial concept of ReA as "sterile arthritis", in which the focus of infection is outside the joint, primarily in the urogenital tract or intestines, has been refuted to date. It has been proven that in ReA, individual microbial antigens and even microorganisms (chlamydia) can be isolated from joint tissues and synovial fluid. Epidemiological studies in ReA are limited due to the lack of unified diagnostic criteria, difficulties in examining patients, and the often asymptomatic course of the trigger infection. However, new pathogens have been identified, such as Mycoplasma pneumoniae, Giardia lamblia, Helicobacter pylori, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus haemolyticus, SARS-CoV-2 and others, which have become the etiological agent of overt ReA. The question of whether streptococcal arthritis, as well as arthritis after acute respiratory viral infections and post-vaccination arthritis, belong to ReA is still controversial. The pathogenesis and mechanisms of ReA development remain unclear. Although classical ReA is associated with HLA-B27, the role of HLA-B27 in ReA development is not fully understood. In most children, ReA is not associated with HLA-B27. Currently, there is no single classification of ReA and no generally accepted diagnostic criteria for the disease. The diagnostic criteria used are developed and focused only on adult patients. Very often, in paediatrics, the main criteria for the diagnosis of ReA are clinical and anamnesis data. In half of the cases, it is practically impossible to establish the etiological factor, and therefore, ultrasound examination of the joints plays a crucial role in the diagnosis of ReA in children. Recommendations for the treatment of ReA in both adults and children need to be updated. There are discrepancies in the recommendations for the treatment of ReA in adults and children. Medications used in adults are not always appropriate for children due to the age-related characteristics of the child's body and possible side effects.

Tags:

children, clinic, diagnosis, reactive arthritis, treatment

Bibliography:

  1. Senatorova AS, Gonchar MA, Pugacheva EA. Informativnost rentgenologicheskogo i ultrazvukovogo metodov issledovaniya v diagnostike reaktivnyh artritov u detej. Zdorove rebenka. 2016;71(3):45-9. [in Ukrainian].
  2. Tugelbayeva А, Ivanova R, Goremykina М, Rymbayeva Т, Toktabayeva B. Reactive arthritis in children (review). Georgian Medical News. 2021;311(2):130-35.
  3. Tverdohleb T. A. Sostoyanie mikrobiocenoza kishechnika i immuniteta u detej bolnyh reaktivnymi artritami v ostrom periode. Svit Medicini ta biologii. 2016;56(2):90-5. [in Ukrainian].
  4. Jubber A, Moorthy A. Reactive arthritis: a clinical review. J R Coll Physicians Edinb. 2021 Sep;51(3):288-97. DOI: 10.4997/JRCPE.2021.319.
  5. Lebec IS, Panko NA. Osobennosti debyuta i techeniya reaktivnyh artritov u detej. Zdorove rebenka. 2013;49(6):37-42. [in Ukrainian].
  6. Taniguchi Y, Nishikawa H, Yoshida T, Terada Y, Tada K, Tamura N, et al. Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection‑related arthritis including poststreptococcal ReA, Poncet’s disease, and iBCG‑induced ReA. Rheumatol Int. 2021;41:1387- 98. DOI: https://doi.org/10.1007/s00296-021-04879-3.
  7. Pennisi M, Perdue J, Roulston T, Nicholas J, Schmidt E, Rolfs J. An overview of reactive arthritis. J Am Acad Physician Assist. 2019;32(7):25- 8. DOI: 10.1097/01.JAA.0000558320.47868.2f.
  8. Zeng H, Luo B, Zhang Y, Xie Z, Ye Z. Treatment of reactive arthritis with biological agents: a review. Biosci Rep. 2020;40(2):BSR20191927. DOI: https://doi.org/10.1042/BSR20191927.
  9. Hayes KM, Hayes RJP, Turk MA, Pope JE. Evolving patterns of reactive arthritis. Clin Rheumatol. 2019;38(8):2083-8. DOI: 10.1007/ s10067-019-04522-4.
  10. Safargalieva LH, Shajmuratov RI, Yagfarova RR, Sharipova RR. Problemy diagnostiki reaktivnogo artrita. Vestnik sovremennoj klinicheskoj mediciny. 2018;11(4):129-35. DOI: 10.20969/VSKM.2018.11(4).129-135.
  11. He T, Qian W. Immunologic derangement caused by intestinal dysbiosis and stress is the intrinsic basis of reactive arthritis. Z Rheumatol. 2024. DOI: https://doi.org/10.1007/s00393-024-01480-4.
  12. Espinoza LR, editor. Infections and the rheumatic diseases. Cham: Springer International Publishing; 2019. 460 p. Available from: http:// link.springer. com/10.1007/978-3-030-23311-2.
  13. Bentaleb I, Abdelghani KB, Rostom S, Amine B, Laatar A, Bahiri R. Reactive Arthritis: Update. Current Clinical Microbiology Reports. 2020;7:124-32. DOI: https://doi.org/10.1007/s40588-020-00152-6.
  14. Pisareva AD, Matvienko EV, Krivdina ND, Hmelevskaya IG, Razinkova NS. Osobennosti techeniya reaktivnyh artritov u detej i podrostkov na sovremennom etape. Kurskij nauchno-prakticheskij vestnik “Chelovek i ego zdorove”. 2018;1:36-9. DOI: 10.21626/vestnik/2018-1/06.
  15. Klimenko VA, Savvo VM, Yanovskaya EA. Osobennosti sovremennogo techeniya reaktivnyh artritov u detej. Svit medicini ta biologiyi. 2014;47(4):42-5. [in Ukrainian].
  16. Kuipers JG, Sibilia J, Bas S, Gaston H, Granfors K, Vischer TL, et al. Reactive and undifferentiated arthritis in North Africa: use of PCR for detection of Chlamydia trachomatis. Clin Rheumatol. 2009;28(1):11-6. DOI: 10.1007/s10067-008-0968-z.
  17. Hajjaj-Hassouni N, Burgos-Vargas R. Ankylosing spondylitis and reactive arthritis in the developing world. Best Pract Res Clin Rheumatol. 2008;22(4):709-23. DOI: 10.1016/j.berh.2008.05.005.
  18. Tumanyan TS, Chachiya TM, Chistyakova EG, Kondrikova EV, Korsunskij AA, Gadeckaya SG, et al. Kliniko-epidemiologicheskie osobennosti reaktivnyh artritov, vyzvannyh kishechnoj infekciej u detej. Pediatriya. 2019;98(3):150-6. DOI: 10.24110/0031-403X-2019-98-3-150- 156.
  19. Schmitt SК. Reactive arthritis. Infect Dis Clin North Am. 2017;31(2):265-77. DOI: http://dx.doi.org/10.1016/j.idc.2017.01.002.
  20. Ajene AN, Walker FCL, Black RE. Enteric Pathogens and Reactive Arthritis: A Systematic Review of Campylobacter, Salmonella and Shigella-associated Reactive Arthritis. J Health Popul Nutr. 2013 Sep;31(3):299-307. DOI: 10.3329/jhpn.v31i3.16515.
  21. Alušík Š. Reactive, infectious, or postinfectious arthritis? Vnitr Lek. 2022;68(7):449-53. DOI: 10.36290/vnl.2022.094.
  22. Skudarnov EV, Kolesnikova OI, Vyhodceva GI, Grigorevskaya OA, Skudarnova AP, Malyuga OM, et al. Svoeobrazie debyuta i klinicheskogo techeniya reaktivnogo artrita u detej. Byulleten medicinskoj nauki. 2021;4(24):39-45. DOI: 10.31684/25418475-2021-4-39.
  23. Cargnelutti E, Di Genaro MS. Reactive arthritis: From clinical features to pathogenesis. Int J Clin Med. 2013;4:20-30. DOI: 10.4236/ ijcm.2013. 412A2004.
  24. Facciola A, Visalli G, Lagana A, Pietro AD. An Overview of Vaccine Adjuvants: Current Evidence and Future Perspectives. Vaccines 2022;10:819. DOI: https://doi.org/10.3390/vaccines10050819.
  25. Kumar P, Khanna G, Batra S, Sharma VK, Rastogi S. Chlamydia trachomatis elementary bodies in synovial fluid of patients with reactive arthritis and undifferentiated spondyloarthropathy in India. Int J Rheum Dis. 2016;19(5):506-11. DOI: 10.1111/1756-185X.12364.
  26. Sharma M, Sharma S, Sharma A, Sharma K. Chlamydia Trachomatis Associated Reactive Arthritis: A Urinary PCR Based Study. Indian Dermatol Online J. 2020;11(1):21-4. DOI: 10.4103/idoj.IDOJ_410_19.
  27. Luccino B, Spinelli FR, Perricone C, Valesini G, Di Franco M. Reactive arthritis: current treatment challenges and future perspectives. Clin Exp Rheumatol. 2019;37(6):1065-76.
  28. Wang CR, Tsai HW. Seronegative spondyloarthropathy-associated inflammatory bowel disease. World J Gastroenterol. 2023;29(3):450- 68. DOI: 10.3748/wjg.v29.i3.450 ISSN 1007-9327.
  29. Chaurasia S, Shasany AK, Aggarwal A, Misra R. Recombinant Salmonella typhimurium outer membrane protein A is recognized by synovial fluid CD8 cells and stimulates synovial fluid mononuclear cells to produce interleukin (IL)-17/IL-23 in patients with reactive arthritis and undifferentiated spondyloarthropathy. Clin Exp Immunol. 2016;185(2):210-18. DOI: 10.1111/cei.12799.
  30. García-Kutzbach A, Chacón-Súchite J, García-Ferrer H, Iraheta I. Reactive arthritis: update 2018. Clin Rheumatol. 2018;37(4):869-74. DOI: 10.1007/s10067-018-4022-5.
  31. Manasson J, Shen N, Garcia H, Ubeda C, Iraheta I, Heguy A, et al. Gut microbiota perturbations in reactive arthritis and post-infectious spondyloarthritis arthritis. Arthritis Rheumatol. 2018;70(2):242-54. DOI: https://doi.org/10.1002/art.40359.
  32. Caminer A, Haberman R, Scher J. Human microbiome, infections and rheumatic disease. Clin. Rheumatol. 2017;36(12):2645-53. DOI: https://doi.org/10.1007/s10067-017-3875-3.
  33. Asquith M, Rosenbaum J. The interaction between host genetics and the microbiome in the pathogenesis of spondyloarthropathies. Curr. Opin. Rheumatol. 2016;28(4):405-12. DOI: https://doi.org/10.1097/BOR.
  34. Bănicioiu-Covei S, Vreju A, Rosu A, Ciurea P. The importance of HLA-B27 in the evolution of reactive arthritis. Curr Health Sci J. 2019;45(4):345-52. DOI: 10.12865/CHSJ.45.04.01.
  35. Bojko YaYe. Diferencialna diagnostika artritiv u ditej. Suchasna pediatriya. Ukrayina. 2019;5(101):112-22. DOI: 10.15574/SP.2019.101.112. [in Ukrainian].
  36. Plesca DA, Luminos M, Spatariu L, Stefanescu M, Cinteza E, Balgradean M. Postinfectious arthritis in pediatric practice. Maedica (Buchar). 2013;8(2):164-9.
  37. Zeidler H, Hudson AP. Quo vadis reactive arthritis? Curr Opin Rheumatol. 2022;34(4):218-24. DOI: 10.1097/BOR.0000000000000880.
  38. Courcoul A, Brinster A, Decullier E, Larbre J-P, Piperno M, Pradat E, et al. A bicentre retrospective study of features and outcomes of patients with reactive arthritis. Joint Bone Spine. 2018;85(2):201-5. DOI: 10.1016/j.jbspin.2017.01.013.
  39. Zeidler H. Geschichte der reaktiven Arthritis. Historische Meilensteine und Zukunft. Z Rheumatol. 2022;81:692-8. DOI: https://doi. org/10.1007/s00393-022-01253-x.
  40. Zeidler H, Hudson AP. Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens. Curr Rheumatol Rep. 2021;23(7):53. DOI: 10.1007/s11926-021-01018-6.
  41. Farisogullari B, Pinto AS, Machado PM. COVID-19-associated arthritis: an emerging new entity? RMD Open. 2022;8:e002026. DOI: 10.1136/rmdopen-2021-002026.
  42. Zarpoosh M, Amirian P, COVID‐associated arthritis after severe and non‐severe COVID‐19: A systematic review. Immun Inflamm Dis. 2023;11:e1035. DOI: 10.1002/iid3.1035.
  43. Saricaoglu EM, Hasanoglu I, Guner R. The first reactive arthritis case associated with COVID-19. J Med Virol. 2021;93(1):192-3. DOI: 10.1002/jmv.26296.
  44. Lahu A, Backa T, Ismaili J, Lahu V, Saiti V. Modes of presentation of reactive arthritis based on the affected joints. Med Arch. 2015;69(1):42- 5. DOI: https://doi.org/10.5455/medarh.2015.69.42-45.
  45. Selmi C, Gershwin ME. Diagnosis and classification of reactive arthritis. Autoimmun Rev. 2014;13:546-9. DOI: 10.1016/j.autrev.2014.01.005.
  46. Carter JD, Hudson AP. Recent advances and future directions in understanding and treating Chlamydia-induced reactive arthritis. Expert Rev Clin Immunol. 2017;13(3):197-206. DOI: 10.1080/1744666X.2017.1233 816.
  47. Fedotov VP. Bolezn Rejtera (istoriya, etiologiya, epidemiologiya, patogenez, klinika i techenie, porazhenie kozhi, glaz, oporno-dvigatelnogo apparata i drugih organov). Klinicheskaya lekciya. Dermatovenerologiya. Kosmetologiya. Seksopatologiya. 2016;1-4:82-107. [in Ukrainian].
  48. Horton DB, Strom BL, Putt ME, Rose CD, Sherry DD, Sammons JS. Epidemiology of Clostridium difficile Infection-Associated Reactive Arthritis in Children: An Underdiagnosed, Potentially Morbid Condition. JAMA Pediatrics. 2016;170(7):e160217 DOI: 10.1001/ jamapediatrics.2016. 0217.
  49. Sinaei R, Pezeshki S, Parvaresh S, Sinaei R, Shiari R, Hassas Yeganeh M, et al. Post SARS-CoV-2 infection reactive arthritis: a brief report of two pediatric cases. Pediatr Rheumatol J. 2021;19(1):89. DOI: 10.1186/s12969-021-00555-9.
  50. Giraudo C, Fichera G, Pilati L, Cortinovis AL, Cavallin C, Bertin S, et al. COVID-19 musculoskeletal involvement in children. Front. Pediatr. 2023;11:1200877. DOI: 10.3389/fped.2023.1200877.
  51. Houshmand H, Abounoori M, Ghaemi R, Bayat S, Houshmand G. Ten-year-old boy with atypical COVID-19 symptom presentation: a case report. Clin Case Rep. 2020;9:304-8. DOI: 10.1002/ccr3.3521.
  52. Beketova GV, Soldatova OV, Goryacheva IP, Alekseenko NV. Differencialnaya diagnostika sustavnogo sindroma v pediatrii chast 1. Artropatii. Pediatriya. Vostochnaya Evropa. 2013;4(04):108-24. [in Ukrainian].
  53. Wendling D, Lukas C, Prati C, Claudepierre P, Gossec L, Goupille P, et al. 2018 update of French Society for Rheumatology (SFR) recommendations about the everyday management of patients with spondyloarthritis. Joint Bone Spine. 2018;85(3):275-84. DOI: 10.1016/j.jbspin.2018.01.006.
  54. Wendling D, Prati C, Chouk M, Verhoeven F. Reactive arthritis: treatment challenges and future perspectives. Curr Rheumatol Rep. 2020;22(7):29. DOI: 10.1007/s11926-020-00904-9.
  55. Barber CE, Kim J, Inman RD, Esdaile JM, James MT. Antibiotics for treatment of reactive arthritis: a systematic review and metaanalysis. J Rheumatol. 2013;40(6):916-28.
  56. Courcoul A, Muis Pistor O, Tebib JG, Coury F. Early treatment of reactive arthritis with etanercept and 2 years follow-up. Joint Bone Spine. 2017;84(3):367. DOI: 10.1016/j.jbspin.2016.05.002.
  57. van Mens LJJ, van de Sande MGH, Menegatti S, Chen S, Blijdorp ICJ, de Jong HM, et al. Brief report: interleukin-17 blockade with secukinumab in peripheral spondyloarthritis impacts synovial immunopathology without compromising systemic immune responses. Arthritis Rheumatol Hoboken NJ. 2018;70(12):1994-2002. DOI: 10.1002/art.40581.
  58. Brinster A, Guillot X, Prati C, Wendling D. Evolution over thirty years of the profile of inpatients with reactive arthritis in a tertiary rheumatology unit. Reumatol Clínica. 2018;14(1):36-9. DOI: 10.1016/j.reuma.2016.08. 001.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 2, 173, 52-67 pages, index UDC 616.72-002-053.2-02-07-08]:001.82

DOI:

10.29254/2077-4214-2024-2-173-52-67

2024 Issue 2, 173
children clinic diagnosis reactive arthritis treatment
27.06.2024
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