Pavlov S. V., Burlaka K. A.

LITERATURE REVIEWS

Scentific article

Cardiovascular diseases occupy one of the most significant health problems. Scientists are actively searching for new methods of diagnosis, validity of hospitalization and quality control of treatment. Biomarkers deserve great attention, some of which, at the moment, are used in everyday clinical practice and reflect the various pathophysiological processes present in cardiovascular diseases. The most well-known of these are: natriuretic peptide, high-sensitivity troponins (hs-cTn), cardiac protein, fatty acid-binding (H-FABP), glutathione transferase P1 (GSTP1), galectin-3, ST2, growth differentiation factor 15 (GDF-15), extracellular heat shock protein 70 (Hsp70), hypoxia induced factor (HIF-1α), Klotho protein, endothelial NO synthase. The clinical value of one marker in both diagnosis and prognosis of outcomes for cardiovascular diseases is limited, since one marker is not prognostically significant. The future use of biomarkers is the use of multimarker panels, which include a specific combination of biomarkers, reflecting the various pathophysiological processes that underlie cardiovascular diseases. For effective use in the diagnosis and treatment of diseases of the cardiovascular system of molecular markers, it is necessary to observe such factors as age, sex, obesity, fraction of the ejection of the left ventricle. The use of biomarkers in practical medicine facilitates rapid more accurate diagnosis of cardiovascular pathologies and screening for the effectiveness of therapy.

biomarkers, cardiovascular diseases, molecular-genetic markers, prognostic value

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«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 49-55 pages, index UDK 616.1-07:577.2.088.7

10.29254/2077-4214-2018-2-144-49-55