Grigorenko V. R.

LITERATURE REVIEWS

Scentific article

Ovarian cancers occupy seventh place in structure of general oncological morbidity and fifth place in structure of female mortality. In Ukraine, from 4 to 5 thousand ovarian cancers are diagnosed every year. Despite close attention to problem of oncological diseases of female reproductive system, the struggle for earlier detection of malignant tumors, new techniques, survival rates are disappointing. Among epithelial tumors serous and mucinous cystadenoma are the most common tumors and constitute about 60% of all ovarian neoplasms and more than 90% of all malignant ovarian neoplasms. For modern diagnostics of ovarian tumors, prognosis, differential approach to treatment of patients, possible tumor response to chemotherapy, it is necessary to optimize the existing oncomarker panels with the simultaneous search for new ones. According to relevance of this topic, we conducted a literature review of modern methods of diagnosis and prognosis of malignant ovarian tumors.

serous ovarian tumors, morphological diagnostics, immunohistochemistry

1. Byuleten natsionalnoho kantser-reyestru Ukrayiny № 18; Kyyiv, 2017. [in Ukrainian].
2. Gocheva V, Joyce JA. Cysteine cathepsins and cutting edge of cancer invasion. Cell Cycle. 2007;6(1):60-4.
3. GBD 2015 Disease and Injury Incidence and Prevalence Collaborators (8 October 2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1545-602.
4. Chi DS, Berchuck A, Dizon DS, Yashar CM. Principles and practice of gynecologic oncology. 7th ed. Philadelphia: Wolters Kluwer Health; 2017. Chapter 23, Epithelial Ovarian Cancer; р. 978-1020.
5. Ivchenko AL. Rak yayichnykov: sovremennye aspekty diahnostyki. Kharkov surgical school. 2015;4:148-51. [in Russiаn].
6. “Ovarian Cancer Prevention (PDQ®)”. NCI. 2014-06-20. Archived from the original on 6 July 2014. Retrieved 1 July2014. р. 19-21.
7. World Cancer Report 2014. World Health Organization. 2014. Chapter 5.12. ISBN 9283204298. Archived from the original on 201609-19. р. 29-32.
8. Tyulyandin SA, Moiseyenko VM. Praktycheskaya onkolohiya: izbranye lektsiyi. Sankt-Peterburh: Tommi; 2004. Chast 4, Rak yaichnikov; s. 70-6. [in Russiаn].
9. American Institute for cancer research. World cancer research fund. Ovarian cancer 2014 report. p. 26-8.
10. Fan L, Prichard J. Handbook of Practical Immunohistochemistry. New York: Springer; 2011. p. 639.
11. Kumar V, Abbas AK, Aster JC. Robbins basic pathology. 9th ed. Canada: Elsevier; 2012. Сhapter 18, Female Genital System and Breast; p. 600-64.
12. Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, et al. GLOBOCAN 2012 v1.1, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research on Cancer; 2014. Available from: http:// globocan.iarc.fr, accessed on 16/01/2015
13. Cancer Facts and Figures 2018. American Cancer Society; 2018 Atlanta, GA. p. 28-44.
14. DeVita VT, Hellman S, Rosenberg SA. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia: Lippincott Williams & Wilkins; 2015. Chapter 76, Ovarian cancer, fallopian tube carcinoma, and peritoneal carcinoma; p. 1051-94.
15. Berek JS. Berek & Hacker’s Gynecologic Oncology. 6th ed. Philadelphia: Wolters Kluwer Health; 2015. Chapter11, Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer; p. 658-701.
16. Doherty JA, Jensen A, Kelemen LE, Pearce CL, Poole E, Schildkraut JM, et al. Current Gaps in Ovarian Cancer Epidemiology: The Need for New Population-Based Research. Journal of the National Cancer Institute [Internet]. 2017;109(10):35-8. Available from: https:// doi.org/10.1093/jnci/djx144
17. Ebell MH, Culp MB, Radke TJ. A Systematic Review of Symptoms for the Diagnosis of Ovarian Cancer. American journal of preventive medicine. 2016 March 14;50(3):384-94. DOI: 10.1016/j.amepre.2015.09.023. PMID 26541098.
18. Hauptmann S, Friedrich K, Redline R, Avril S. Ovarian borderline tumors in the 2014 WHO classification: evolving concepts and diagnostic criteria. Virchows Archiv [Internet]. 2016 Dec 27;470(2):125-42. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC5298321/. DOI: 10.1007/s00428-016-2040-8
19. Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, Kastan MB, McKenna WG, et al. 5th ed. Philadelphia: Elsevier; 2014. Chapter 89, Cancers Arising in the Ovary; p. 1389-405.
20. Hoffman BL, Schorge JO, Schaffer JI, Halvorson LM, Bradshaw KD, Cunningham FG. Epithelial Ovarian Cancer. Williams Gynecology (2nd ed.). McGraw Hill Medical. 2012. р. 853-78. ISBN 978-0-07-171672-7.
21. Ramalingam P. Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer. Oncology (Williston Park). 2016 Feb;30(2):166-76.
22. Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int. J. Gynecol. Cancer. 2009;19(1):58-64.
23. Sundar S, Neal RD, Kehoe S. Diagnosis of ovarian cancer. BMJ. 2015;351:h4443.
24. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO Classificaihion of Tumours of Female Reproductive Organs. Fourth Edition IARS: Lyon; 2014. р. 11-83.
25. Ovarian Epithelial Cancer Treatment (PDQ®). NCI [Internet]. 2014-05-12. Archived from the original on 5 July 2014. Retrieved 1 July 2014. р. 54-70.
26. What are the risk factors for ovarian cancer? 2016-02-04. Archived from the original on 17 May 2016. Retrieved 18 May 2016. www. cancer.org.
27. Ozhyhanova IN. Morfolohiya raku yayechnykiv v klasyfikatsiyi VOZ 2013 roku. Praktychna onkolohiya. 2014;4;15:143-52. [in Ukrainian].
28. Ovarian Cancer Prevention (PDQ®). NCI [Internet]. 2013 December 6. Archived from the original on 6 July 2014. Retrieved 1 July 2014. Available from: https://www.cancer.gov/types/uterine/hp/endometrial-prevention-pdq
29. SEER Stat Fact Sheets: Ovary Cancer. NCI [Internet]. Archived from the original on 6 July 2014. Retrieved 18 June 2014. Available from: https://seer.cancer.gov/statfacts/html/ovary.html
30. GBD 2015 Mortality and Causes of Death Collaborators (8 October 2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-544. DOI: 10.1016/S0140-6736(16)31012-1
31. Seiden M. Gynecologic Malignancies Chapter 28 [Internet]. MGraw-Hill Medical. Archived from the original on September 10, 2017. Retrieved June 24, 2017. Available from: https://accessmedicine.mhmedical.com/content.aspx?bookid=379&Sectionid=39902056
32. National Cancer Institute. Defining Cancer [Internet]. Archived from the original on 25 June 2014. Retrieved 10 June 2014. Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oncology
33. Ovarian cancer. DynaMed [Internet]. June 18, 2015. Archived from the original on June 21, 2015. Available from: https://dynamed. com/home/features/specialty-content
34. Ruddon, Raymond W. (2007). Cancer biology (4th ed.). Oxford: Oxford University Press: 223. ISBN 9780195175431. Archived from the original on 2015-09-15.
35. Piek JM, van Diest PJ, Verheijen RH. Ovarian carcinogenesis: an alternative hypothesis. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 2008;622:79-87. DOI: 10.1007/978-0-387-68969-2_7. ISBN 978-0-387-68966-1. PMID 18546620.
36. Jayson GC, Kohn EC, Kitchener HC, Ledermann JA. (October 2014). Ovarian cancer. Lancet. 2014;384(9951):1376-88. DOI: 10.1016/ S0140-6736(13)62146-7. PMID 24767708.
37. Grossman DC, Curry SJ, Owens DK, Barry MJ, Davidson KW, Doubeni CA, et al. Screening for Ovarian Cancer. JAMA. 2018;319(6):588. DOI: 10.1001/jama.2017.21926
38. Gibson SJ, Fleming GF, Temkin SM, Chase DM. The Application and Outcome of Standard of Care Treatment in Elderly Women with Ovarian Cancer: A Literature Review over the Last 10 Years. Frontiers in Oncology. 2016;6;63:1-8. DOI: 10.3389/fonc.2016.00063. PMC 4805611.
39. Seiden MV. Gynecologic Malignancies. In Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo J. Harrison’s Principles of Internal Medicine. 18th ed. [Internet]. McGraw-Hill. 2012. ISBN 978-0-07-174889-6. Available from:https://archive.org/stream/ DennisKasperAnthonyFauciStephenHauserDanLongoJ.JamesonJosephLoscalzoHarrisonsPri/Dennis+Kasper%2C+Anthony+Fauci% 2C+Stephen+Hauser%2C+Dan+Longo%2C+J.+Jameson%2C+Joseph+Loscalzo-Harrison%27s+Principles+of+Internal+Medicine.+2+ vols.-McGraw-Hill+%282015%29_djvu.txt
40. Ovarian Cancer, Inside Knowledge, Get the Facts about Gynecological Cancer. Centers for Disease Control and Prevention [Internet]. September 2016. Archived (PDF) from the original on June 16, 2017;26 Retrieved June 17, 2017. This article incorporates public domain material from websites or documents of the Centers for Disease Control and Prevention. Available from: https://www.cdc.gov/ niosh/docs/2014-123/pdfs/2014-123.pdf
41. Ovarian cancer symptoms [Internet]. Archived from the original on 2015-05-12. Retrieved 2015-05-16. www.cancerresearchuk.org.
42. Shulʹha AV, Basynsʹkyy VA, Savytsʹkyy SE. Prohnostychne znachennya r53 i z-erb-2 onkoproteinov pry raku yayechnykiv. Visnyk VHMU. 2009;8;3:1-11. [in Ukrainian].
43. Shulʹha AV, Basynsʹkyy VA, Lyalikov SA. Kompleksna otsinka i matematychne modelyuvannya prohnozu raku yayechnykiv. HrHMU. 2010;1:98-100. [in Ukrainian].
44. Ochiai K. Prognostic factors of ovarian cancer: Gan To Kagaku Ryoho. 2006;33:2014-9. 

«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 17-22 pages, index UDK 618.11-006.04-07-037

10.29254/2077-4214-2018-2-144-17-22