Chornij N. V., Manashchuk N. V., Boytsanyuk S. I., Chornii A. V., Zaliznyak M. S.

LITERATURE REVIEWS

Scentific article

A comprehensive approach to the treatment of periodontal diseases provides high efficiency and long-term remission of the disease. When choosing medication therapy special attention is paid to the form of symptomatic gingivitis, the nature of the course of the inflammatory or dystrophic-inflammatory process in the periodontium (chronic or acute), the degree of development of generalized periodontitis, the presence of the contents and microbial composition of periodontal pockets. In the complex treatment of periodontal diseases, drugs are traditionally used, primarily antiseptics. In addition to natural and synthetic antiseptic drugs for inflammatory periodontal disease, nonsteroidal anti-inflammatory drugs are widely used. This became the basis for the analysis of literary sources in order to study the varieties of nonsteroidal antiinflammatory drugs, which are shown for use in dentistry. Search of literature has taken place in library sources and search engines http://www.google.com.ua, www. meta.ua, Pub Med. Research results. The results of the analysis of literary data have shown that for the treatment of periodontal tissues, predominantly medicinal preparations with local anti-inflammatory action are used. Nonsteroidal antiinflammatory drugs (NSAIDs) are virtually the only group of pharmacological agents that act primarily on local reactive processes in the periodontal disease. The basis of the pharmacological action of this group of drugs lies in their ability to block the enzyme cycloohygenase and at the same time to prevent the transformation of arachidonic acid into various prostaglandins. Indications for the use of NSAIDs in periodontics are all types of gingivitis and periodontitis. Local anti-inflammatory agents can be used as irrigation, application, periodontal bandages, sprays, lollipops, as well as for introduction into periodontal pockets. In the period of active treatment of gingivitis, generalized periodontitis and other infectious and inflammatory diseases of the oral cavity anti-inflammatory drugs can be used both in the clinic and patients themselves. It should be noted that the purpose of the use of these drugs at home should be carried out only at the appointment of a doctor with clear indications for use. The duration of use at home should not ehceed 10-14 days. Nonsteroidal anti-inflammatory drugs are characterized not by the specificity of the action, ie, the antiinflammatory effect is manifested when inflammation of any genesis and localization. Drugs of different groups differ from each other for the severity of anti-inflammatory action. In general, NSAIDs are highly tolerated, not cumulated, quickly removed from the body. Side effects of NSAIDs: can provoke destructive processes in cartilage and bone tissues, breaking the synthesis of collagenase, elastase, glycoproteins, collagen and other proteins necessary for regeneration of cartilage and bones, gastritis, erosion and ulcers of the gastrointestinal tract, gastroesophageal refleh, cholestasis, hepatitis, jaundice, bronchial spasm, reduce diuresis and cause swelling; kidney damage, liver damage, immediate and delayed allergic reactions, acetylsalicylic acid derivatives o is the ototohic effect. For prophylahis of gastropathy promising is the use of misoprostol – an analogue of prostaglandin, which prevents the development of adverse reactions from the side of the gastrointestinal tract. Conclusion. The effectiveness of the use of nonsteroidal anti-inflammatory drugs in the treatment of periodontal diseases is beyond doubt and is based on evidence-based medicine. However, when choosing drugs in the treatment of gingivitis and periodontitis, preference should be given to drugs that have a complex effect and to locally affect the pathogenesis pathways without complications from the macro-organism.

nonsteroidal anti-inflammatory drugs, gingivitis, chronic generalized periodontitis

1. Antonenko MYu, Sydelnykova LF, Dudnykova MO. Efektyvnist vklyuchennya etytropnyh preparativ u kompleksnu gigiyenu porozhnyny rota na rannih etapah rozvytku zahvoryuvan parodonta. Sovremennaya stomatologyya. 2010;11:49-52. [in Ukrainian].
2. Bezrukova YV, Aleksandrovskaya YYu. Prymenenye sredstv pryrodnogo proyshodzhenyya pry zabolevanyyh parodonta. Parodontologyya. 2003;3(28):42-6. [in Russiаn].
3. Kazaryna LN, Lavrenteva AV. Ocenka еffektyvnosty lechenyya hronycheskogo generalyzovannogo parodontyta u voennosluzhashhyh, perenеsshyh „boevoj” stress, s prymenenyem preparata „Lysobakt”. Parodontologyya. 2010;4(57):61-4. [in Russiаn].
4. Kucevlyak VF. Opyt рrymenenyya preparata „Lysobakt” v klynyke terapevtycheskoj stomatologyy. Stomatolog. 2003;3:23-5. [in Russiаn].
5. Barer GM, Lemeczkaya TY. Bolezny parodonta. Klynyka, dyagnostyka y lechenye: uchebnoe posobye. M.: VUNMCz; 1996. 85 s. [in Russiаn].
6. Danylevskyj MF, Mohort MA, Mohort VV. Farmakoterapiya zahvoryuvan slyzovoyi obolonky porozhnyny rota i tkanyn parodonta. K.: Zdorov’ya; 1991. 264 s. [in Ukrainian].
7. Yvanov VS. Zabolevanyya parodonta. 4-e yzd., pererab. y dop. M.: Med. ynform. agenstvo; 2001. 300 s. [in Russiаn].
8. Levyczkyj AP. Lyzocym vmesto antybyotykov. Odessa; 2005. 73 s. [in Russiаn].
9. Mazur IP, Perederij VA, Dulko SV. Farmakologichni zasoby dlya miscevogo likuvannya tkanyn parodontu. Sovremennaya stomatologyya. 2010;5:47-52. [in Ukrainian].
10. Leontev AA. Kompleksnyj podhod k profylaktyke zabolevanyj parodonta. Parodontologyya. 2010;2(55):76-7. [in Russiаn].
11. Lohmatova NM. Zastosuvannya antyseptyka «Dekasan» u ditej u razi likuvannya hronichnogo kataralnogo gingivitu. Materialy II (IH) z’yizdu Asociaciyi stomatologiv Ukrayiny. K.: Knyga plyus; 2004. s. 112-3. [in Ukrainian].
12. Maslij YuS, Ruban OA. Novi mozhlyvosti miscevoyi antybakterialnoyi terapiyi zapalnyh zahvoryuvan parodontu. Ukr. zhurnal klin. ta labor. Medycyny. 2011;6(1):86-9. [in Ukrainian].
13. Veber VR, Moroz BT. Klynycheskaya farmakologyya dlya stomatologov: uchebnoe posobye. S. Pb.: Chelovek; 2003. 352 s. [in Russiаn].
14. Gazhva SY, Voronyna AY. Sravnytelnaya ocenka effektyvnosty lechenyya hronycheskogo generalyzovannogo parodontyta legkoj y srednej stepeny tyazhesty s yspolzovanyem antybakteryalnyh sredstv „Asepta”. Parodontologyya. 2009;3(52):56-60. [in Russiаn].
15. Chumakova YuH, Borodenko DY, Kosoverova MA. Otsenka terapevtycheskykh еffektov zubnoi pastу y balzama dlia polosty rta «VIVAH DENT» na modely parodontyta u krуs. Sovremennaia stomatolohyia. 2016;3:29-31. [in Russiаn].
16. Kuryakyna NV, Kutepova TF. Zabolevanyya parodonta. M.: Medycynskaya knyga, N. Novgorod: Yzdatelstvo NGMA; 2000. 160 s. [in Russiаn].
17. Fedy P, Vernyno A, Grej Dzh, redaktory. Parodontologycheskaya azbuka. Per. s angl. Yzdatelskyj dom «Azbuka»; 2003. 287 s. [in Russiаn].
18. Tsepov LM, Nykolaev AY. Dyahnostyka y lechenye zabolevanyi parodonta. M.: MEDpress-ynform; 2002. 192 s. [in Russiаn].
19. Matthews RW, Scully CM, Levers BGH, Hislop WS. Clinical evaluation of benzydamine, chlorhehidine, and placebo mouthwashes in the management of recurrent aphthous stomatitis. Oral Surg. Oral Med. Oral Pathol. 1987;63(2):189-91.
20. Borysenko AV, Magomedov S, Fedyanovych IM. Ocinka efektyvnosti osteotropnoyi terapiyi generalizovanogo parodontytu. Implantologiya. Parodontologiya. Osteologiya. 2006;1:86-8. [in Ukrainian].
21. Perova MD. Byologycheskye mehanyzmy reparatyvnoj regeneracyy tkanej parodonta. Novoe v stomatologyy. 2001;8:62-70. [in Russiаn].
22. Pleskanovskaia NV, Yppolytov EV, Tsarev VN. Obosnovanye y otsenka еffektyvnosty mestnoi kombynyrovannoi (protyvovospalytelnoi, antybakteryalnoi y ymmunotropnoi) terapyy v kompleksnom lechenyy vospalytelnуkh zabolevanyi parodonta. Stomatolohyia. 2013;1:26-30. [in Russiаn].
23. Tsepov LM, Nykolaev AY, Kovaleva OV. „Kuryozyn” y novye vozmozhnosty lechenyia khronycheskoho heneralyzovannoho parodontyta. Parodontolohyia. 2004;2(31):20-5. [in Russiаn].
24. Dmytryeva LA. Parodontyt. Moskva: MEDpress-ynform; 2007. s. 70-9, 100-63. [in Russiаn].
25. Zabolotnyi TD, Borysenko AV. Zapalni zakhvoriuvannia parodonta. Lviv: HalDent; 2013. 205 s. [in Ukrainian].
26. Grygoryan AS, Grudyanov AY, Rabuhyna NA, Frolova OA. Bolezny parodonta. Patogenez, dyagnostyka, lechenye. M.: Medycynskoe ynformacyonnoe agentstvo; 2004. 320 s. [in Russiаn].
27. Kovalenko VN, Viktorov AP, redaktory. Kompendium 2010. K.: Morion; 2010. 1000 s. [in Ukrainian].
28. Kashivska RS, Melnychuk GM, Melnychuk AS, Bazalyczka OV. Medykamentozne likuvannya hvorob parodonta. Grupy preparativ, mehanizm yih diyi, pokazannya ta protypokazannya do vykorystannya. Chastyna V. Fermenty-keratolityky, antyprotozojni preparaty i keratoplastyky. Galyczkyj likarskyj visnyk. 2014;21(2):127-32. [in Ukrainian].
29. Malysheva MV. Mestnoe lechenye vospalytelnуh zabolevanyj parodonta. Ynstytut stomatologyy. 2002;2:16-7. [in Russiаn].
30. Melnychuk GM, Zaverbna LV, Melnychuk AS, Kashivska RS. Medykamentozne likuvannya hvorob parodonta. Grupy preparativ, mehanizm yih diyi, pokazannya ta protypokazannya do vykorystannya. Chastyna I. Antyseptyky roslynnogo pohodzhennya. Oglyad literatury. Novyny stomatologiyi. 2013;1:92-7. [in Ukrainian].
31. Keefe DM, Schubert MM, Elting LS, Epstein JB, Raber-Durlacher JE, Migliorati CA, et al. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer. 2007;109(5):820-31.
32. Orehova LYu, redaktor. Zabolevanyya parodonta. M.: Poly Medya Press; 2004. 432 s. [in Russiаn].
33. Chaban I, Shelepeten L, Grynovecz V, Zosim I. Likarski zasoby dlya likuvannya stomatologichnyh zahvoryuvan. Dovidkovyj posibnyk dlya studentiv ta likariv-interniv. Lviv: „Liga-Pres”; 2004. 95 s. [in Ukrainian].
34. Melnychuk GM, Zaverbna LV, Melnychuk AS, Kashivska RS. Medykamentozne likuvannya hvorob parodonta. Grupy preparativ, mehanizm yih diyi, pokazannya ta protypokazannya do vykorystannya. Chastyna II. Syntetychni antyseptyky. Oglyad literatury Novyny stomatologiyi. 2013;2:79-84. [in Ukrainian].
35. Mangano G, Apicella C, Vitiello M, Milanese C, Polenzani L. Benzydamine Local Anestetic Activity And [3h]-Batrachotohin Binding Sites. Poster presented to 31-st National Congress of the Italian Society of Pharmacology. Trieste, Italy. June 26-29, 2003.
36. Danylevskyj NF, Borysenko AV. Zabolevanyya parodonta. K.: Zdorov’ya; 2000. 464 s. [in Russiаn].
37. Melnychuk GM, Rozhko MM, Zaverbna LV. Gingivit, parodontyt, parodontoz: osoblyvosti likuvannya: navchalnyj posibnyk. Vyd. 5-e, vypravlene i dopovnene. Ivano-Frankivsk, 2011. 328 s. [in Ukrainian].
38. Preshaw PM. Definitions of periodontal disease in research. J. Clin. Periodontology. 2009;36(1):1-2.
39. Melnychuk GM, Zaverbna LV, Melnychuk AS, Kashivska RS. Medykamentozne likuvannya hvorob parodonta. Grupy preparativ, mehanizm yih diyi, pokazannya ta protypokazannya do vykorystannya. Chastyna III. Nesteroyidni protyzapalni preparaty. Oglyad literatury. Novyny stomatologiyi. 2013;3:82-7. [in Ukrainian].
40. Kashivska RS, Melnychuk GM, Melnychuk AS, Bazalyczka OV. Medykamentozne likuvannya hvorob parodonta. Grupy preparativ, mehanizmyih diyi, pokazannya ta protypokazannya do vykorystannya. Chastyna IV. Preparaty z protynabryakovoyu i sklerozuyuchoyu diyeyu. Oglyad literatury. Galyczkyj likarskyj visnyk. 2014;1. [in Ukrainian].
41. Pyekalnyts YYa, Savvydy GL, Bytyukov VA. Rezultaty kompleksnogo lechenyya bolnyh hronycheskym generalyzovannym parodontytom srednejtyazheloj stepeny. Parodontologyya. 2009;4(53):38-41. [in Russiаn].
42. Barer GM, Zoryan EV, Agapov VS. Racyonalnaya farmakoterapyya v stomatologyy: dlya praktykuyushhyh vrachej. M.: Lytterra; 2006. 568 s. [in Russiаn].
43. Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J, et al. Clinical practice guidelines for the prevention and treatment of cancer therapy induced oral and gastrointestinal mucositis. Cance. 2004;1.100(9 Suppl.):2026-46.
44. Syvovol SY. Klynycheskye aspekty parodontologyy. 2-e yzd., pererab. y dop. M.: «Tryada-H»; 2001. 168 s. [in Russiаn].
45. Tarnavska LV. Optymizaciya pislyaoperacijnogo periodu pry hirurgichnomu likuvanni hvoryh na generalizovanyj parodontyt z vykorystannya etamzylatu ta kuriozynu [avtoreferat]. Ivano-Frankivsk, 2007. 18 s. [in Ukrainian].
46. Tsepov LM. Zabolevanyia parodonta, vzghliad na problemu. M.: MEDpress-ynform; 2006. 192 s. [in Russiаn].
47. Reteitschak KH, Reteitschak EM, Wolf HF, Hassel TM. Periodontology. 2nd edition. Color Atlas of Dental Medicine. Thyme Medical Publishers, Inc., New York; 1989. 399 p.
48. Trezubov VN, Myshnеv LM, Marusov YV, Solovеva AM. Spravochnyk vracha-stomatologa po lekarstvennym preparatam. S.-Pt.: YKF „Folyant”; 1999. 349 s. [in Russiаn].
49. Moder T, Yucel-Lindberg T. Benzydamine reduces prostaglandin production in human gingival fibroblasts challenged with interleukin-1 beta or tumor necrosis factor alpha. Acta odontol. scand. 1999;57(1):40-5.
50. Pina-Vaz C, Rodrigues AG, Sansonetty F, Martinez-De-Oliveira J, Fonseca AF, Mеrdh PA. Antifungal activity of local anaesthetic against Candida Species. Infectious diseases in obstetrics and gynecology. 2000;8:124-37.
51. Roopashri G, Jayanthi K, Guruprasad R. Contemp. Clin. Dent. 2011 Jan.-Mar;2(1):8-12.
52. Danylevskyi MF, Borysenko AV, Politun AM. Terapevtychna stomatolohiia: pidruchnyk: u 4 t. Zakhvoriuvannia parodonta. T. 3. K.: Medytsyna; 2008. 616 s. [in Ukrainian].
53. Borysenko AV, Shekera OO, Kolenko YuG. Obgruntuvannya і ocinka efektyvnosti sposobu likuvannya hronichnogo kataralnogo gingivitu u vagitnyh z akusherskoyu patologiyeyu. Sovremennaya stomatologyya. 2011;2:27-31. [in Ukrainian].
54. Dmytryevа LA, redaktor. Sovremennye aspekty klynycheskoj parodontologyy. M.: MEDpress; 2001. 128 s. [in Russiаn].

«Bulletin of problems biology and medicine» Issue 4 Part 2 (147), 2018 year, 89-93 pages, index UDK 616.31–085+616.314.18–002.4+615.281.9

10.29254/2077-4214-2018-4-2-147-89-93