Solovey Yu. M.

METHODS AND METHODOLOGIES

Scentific article

Under the conditions of the experiment on 273 white nonlinear mature rats with simulated abdominal sepsis of varying severity (mild, moderate and severe) developed a design of differential Mueller-matrix tomography study (polarization tomography) polycrystalline tomography or polycrystalline components laboratory rats with abdominal sepsis. An album of distribution maps of the magnitude of linear birefringence of polycrystalline films of rat blood from control group 1 and experimental groups 2-4 with different severity of septic pathology was obtained. The statistical significance of the differentiation of polarization tomograms of linear birefringence of polycrystalline blood films of rats from control group 1 and experimental groups 2-4 with different severity of septic pathology was determined. The most diagnostically sensitive statistical criteria for differentiation of polarization tomograms of linear birefringence of polycrystalline blood films of rats from control group 1 and experimental groups 2-4 with different severity of septic pathology were found. The operational characteristics of the diagnostic power of the method of polarization-phase tomography of polycrystalline blood films of rats of control and experimental groups are determined. Balanced accuracy has been established: differentiation of healthy and sepsis-infected rats; intergroup differentiation of the severity of the septic process in sick rats; intragroup differentiation of patients with sepsis in rats. From the obtained results it follows that abdominal sepsis is characterized by a decrease in optical anisotropy (linear birefringence) of the polycrystalline component of the blood films of rats from all experimental groups. The revealed fact is indicated by the decrease in the value of the mean and the variance of the linear birefringence at the points of the plane of the biological preparation.

abdominal sepsis, experiment, method of differential Mueller-matrix mapping.

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«Bulletin of problems biology and medicine» Issue 4 (162), 2021 year, 238-242 pages, index UDK 616-073.763.5:535.51:617.55-002.3

10.29254/2077-4214-2021-4-162-238-242