Kosopas N. M., Maksymyuk G. V., Lapovets L. E., Odnorig L. O.

LITERATURE REVIEWS

Scentific article

The metabolic syndrome is known to be associated with an increased risk of developing cardiovascular disease. However, studies of recent decades have shown that the metabolic syndrome (MS) also affects other systems of the body, including the male reproductive system. This literary review is devoted to the current definition of metabolic syndrome and its pathogenetic interaction of MS components with male infertility. The National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III) defined MS as a combination of at least three of the following abnormalities: waist circumference > 102 cm in men or > 88 cm in women, serum triglycerides > 150 mg/dl, HDL-cholesterol < 40 mg/dl in men or < 50 mg/dl in women, blood pressure > 130/85mm Hg and serum glucose > 110 mg/dl. The MS may adversely affect the male reproductive system by several mechanisms: hormonal, thermal, sexual, epigenetic and others. Each component may act both in isolation and in combination with other factors, causing disturbance of normal spermatogenesis. Consequently, changes of semen parameters, such as reduced sperm concentration, total sperm count, morphological disturbances are observed. Previously it was assumed that the pro-inflammatory state and the further development of oxidative stress, may play a role in the pathophysiological relationship between the components of the metabolic syndrome and male infertility. The analysis of correlations of metabolic syndrome, obesity, pro-inflammatory state with semen quality was performed. A number of studies report a negative correlation between obesity, an increase in body mass index (BMI) and the main semen parameters. However, data from some studies are quite controversial. For example, one of the largest meta-analyses in this area reports the lack of correlation between BMI and sperm concentration, total spermatozoa count. The number of studies devoted to the relationship between MS and sperm quality is very limited. Lotti and Leisegang suggest a significant decrease in the concentration, total sperm count and progressive sperm motility in men with MS. Only a few groups of researchers estimated the inflammation of the genital tract in patients with elevated BMI. Such controversial data suggest that additional studies of the complex pathophysiology of metabolic syndrome and its effects on male infertility are required. The interdisciplinary approach will enable the expansion of understanding of pathogenesis of male infertility in context of the metabolic syndrome and beyond.

metabolic syndrome, obesity, body mass index, male infertility

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«Bulletin of problems biology and medicine» Issue 2 (144), 2018 year, 26-30 pages, index UDK 612.35+612.33+612.11/.12).014.3:612.22

10.29254/2077-4214-2018-2-144-26-30