Pastukhova V. A., Oliinichenko M. O.

MECHANISMS OF INFLUENCE OF EXOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE ADRENAL GLANDS

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About the author:

Pastukhova V. A., Oliinichenko M. O.

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LITERATURE REVIEWS

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Scientific article

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The article deals with morphological and functional changes in the adrenal glands under various exogenous factors. Particular attention is paid to the role of nutritional supplements, stress and thermal injury on the functional activity of the adrenal glands. Changes in the structure of the cortex and medulla of the adrenal glands under the influence of irritating factors are analysed. The consequences of such changes are analysed, in particular, the impaired synthesis of adrenal hormones: corticosteroids, adrenaline and norepinephrine, which can lead to metabolic disorders, immune response disorders and the overall adaptive potential of the body. The adrenal glands are not only a part of the hypothalamic-pituitary-adrenal system but also essential organs of the endocrine system. They target organs not only for exogenous influences but also as indicators of the state of the body's adaptive system, which is relevant for studying and understanding the pathogenesis of various diseases of the endocrine system and developing effective preventive and therapeutic strategies. The study aimed to determine the mechanisms of exogenous factors' influence on the morphological and functional state of the adrenal glands. In particular, it investigated structural and functional changes that occur under the influence of chemical, physical, and stress factors. It also substantiated approaches to minimise their negative impact on maintaining the normal functioning of the body as a whole. There is a need for further research into the impact of various stimuli on the adrenal glands, as modern lifestyles, environmental pollution, and stress can cause new irreversible changes. Understanding these mechanisms will allow us to develop effective strategies for preventing and treating endocrine disorders, in particular by minimising the impact of external factors and optimising nutrition.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 69-75 pages, index UDC 611.451+612.451]:612.014.4

DOI:

10.29254/2077-4214-2025-1-176-69-75