Poladych I. V., Antoniuk M. I.

MARKERS OF CALCIUM-PHOSPHORUS METABOLISM AS PROGNOSTIC FACTORS OF OBSTETRIC COMPLICATIONS

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About the author:

Poladych I. V., Antoniuk M. I.

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CLINICAL AND EXPERIMENTAL MEDICINE

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Scientific article

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Pregnancy is accompanied by numerous physiological changes, among which calcium-phosphorus metabolism draws particular attention. Alterations in the metabolism of trace elements such as calcium, magnesium, phospho rus, and vitamin D are critically important for the normal course of pregnancy and the prevention of obstetric complications. In particular, vitamin D deficiency has been associated with the development of preeclampsia, intrauterine growth restriction (IUGR), and other pregnancy-related pathologies. In a study conducted from October 2023 to September 2024, calcium-phosphorus metabolism was assessed in pregnant women with varying vitamin D levels. A total of 114 participants were divided into three groups: those with vitamin D deficiency (Group I), insufficiency (Group II), and optimal vitamin D status (control group). It was found that women with vitamin D deficiency had the lowest levels of 25(OH)D, which was accompanied by decreased ion ized calcium levels and elevated parathyroid hormone levels. Low vitamin D levels were also associated with a higher incidence of obstetric complications such as preeclampsia, preterm birth, and IUGR. The results of the study confirm the importance of evaluating calcium-phosphorus metabolism in pregnant women as a tool for early detection of obstetric risk, particularly for preeclampsia and other serious conditions. The level of 25(OH)D has prognostic value in predicting pregnancy complications, emphasizing the need for timely diag nosis and correction of vitamin D status in pregnant women.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 253-260 pages, index UDC 618.2-07:612.014.4:577.1

DOI:

10.29254/2077-4214-2025-2-177-253-260