Kryzhna S. I., Kievska Yu. A., Tyupka T. I., Kozar V. V.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

One of the stages of pharmacological research of the new gel “Imbirol” containing a complex of essential oils was carried out. It has been proved that the basis of pathogenesis of chemical and bacterial rhinitis has the activation of lipid peroxidation and the reduction of antioxidant activity in injury of mucous layer of nose in experimental model. In case of application of powerful universal treatment with gel “Imbirol” in experimental rhinitis contributes to the normalization of the indicators of the system “peroxidation-antioxidant protection”. “Imbirol” shows pronounced therapeutic antioxidant properties in comparison with the reference preparation “Pinosol”. Thus, the increase in the level of catalase and reduced glutathione in chemical rhinitis was 123.4% in the group with “Imbirol” and 91.6% in the group with “Pinosol”; reduced glutathione increased in the group with “Imbirol” by 166.1% and by 91.9% in the group with “Pinosol”. The effectiveness of the new gel “Imbirol” has a more positive dynamics of prooxidant-antioxidant system recovery of the nasal mucosa during the development of experimental rhinitis and does not differ significantly from the parameters of the reference preparation “Pinosol”. The simulation of chemical and bacterial rhinitis reliably reflected the disturbance of the prooxidant-antioxidant system of the mucous membrane of the nasal passages of rats by increasing thiobarbituric acid and diene conjugates, and decreasing catalase and glutathione even at 12 days of the experiment.

rhinitis, prooxidant-antioxidant system, mucous membrane, gel

• Belenіchev I.F. Antioksidanti: suchasne uyavlennya, perspektivi stvorennya / І.F. Belenіchev, S.І. Kovalenko, V.V. Dunaеv // Lіki. – 2006. – № 1. – S. 35-40.
• Vybor optimalnogo sredstva dlya mestnogo lecheniya faringita u detej / Yu.L. Soldatskij, E.K. Onufrieva, S.F. Gasparyan [i dr.] // Na dopomogu pedіatru. – 2014. – № 1 (52). – S. 105-108.
• Korolyuk M.A. Metod opredeleniya aktivnosti katalazy / M.A. Korolyuk, L.I. Ivanova, I.G. Majorova, V.E. Tokarev // Laboratornoe delo. – 1988. – № 1. – S. 16-19.
• Levicka S.A. Patofіzіologіchne znachennya xronіchnix zaxvoryuvan verxnіx і nizhnіx dixalnix shlyaxіv v rozvitku chastix recidivіv respіratornix vіrusnix іnfekcіj u dіtej / S.A. Levicka, A.І. Gozhenko, V.V. Buyalo // Aktualnye problemy transportnoj mediciny. – 2014. – № 1 (35). – S. 145-148.
• Nosova Ya.V. Razrabotka metoda ekspress-diagnostiki bakterialnoj mikroflory polosti nosa / Ya.V. Nosova, X. Faruk, O.G. Avrunin // Problemi іnformacіjnix texnologіj. – Xerson, 2013. – № 13. – S. 99-104.
• Pul-Luzan V.V. Razrabotka texnologii gelya dlya lecheniya zabolevanij verxnix dyxatelnyx putej / V.V. Pul-Luzan, I.I. Baranova, S.A. Mamedova // Farmaciya Kazaxstana. – 2014. – № 9. – S. 50-54.
• Rukovodstvo po eksperimentalnomu (doklinicheskomu) izucheniyu novyx farmakologicheskix veshhestv: metod. rek. / pod red. R.U. Xabrieva. – M.: Medicina, 2005. – 832 s.
• Stalnaya I.D. Metod opredeleniya dienovyx konyugatov / I.D. Stalnaya, T.G. Garishvili // Sovremennye metody v bioximii. – M.: 1977. – S. 43-44.
• All-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties / I. Liakos, L. Rizzello, D.J. Scurr [et al.] // Int. J. Pharm. – 2014. – Vol. 463, № 2. – P. 137-145.
• Beutler E.D. Improved method for the determination of blood glutathione / E.D. Beutler, O. Duron, B.M. Kelly // J Lab Clin Med. – 1963. – V. 61, № 5. – P. 882-888.

«Bulletin of problems biology and medicine» Issue 4 Part 3 (141), 2017 year, 150-153 pages, index UDK 615.454.1:615.322:615.23:616.22/.23

10.29254/2077–4214–2017–4–3–141–150-153