Boiko S. O., Pushkash I. I., Popovych Ya. M., Skripynets Yu. P.

INNOVATIVE APPROACH TO THE TREATMENT OF KNEE OSTEOARTHRITIS AND ARTHRITIS: CARBOXYTHERAPY AS A MODIFIER OF MICROCIRCULATION AND INFLAMMATION

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About the author:

Boiko S. O., Pushkash I. I., Popovych Ya. M., Skripynets Yu. P.

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LITERATURE REVIEWS

Type of article:

Scientific article

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Knee osteoarthritis remains one of the pressing problems of modern medicine due to its high prevalence, chronic course, and significant negative impact on the quality of life of patients. Accumulated scientific data indicate that impaired microvascular perfusion, local tissue hypoxia, endothelial dysfunction, and persistent low-level inflammation play an important role in the progression of the disease, forming an unfavorable metabolic environment in the articular and periarticular tissues. In these pathophysiological conditions, standard therapeutic approaches are predominantly symptomatic and have limited impact on the pathogenetic mechanisms of osteoarthritis. Physiotherapy methods aimed at correcting microcirculatory and metabolic disorders are of particular scientific interest. Carboxytherapy, which involves local or transcutaneous application of carbon dioxide, is considered an approach with a multilevel mechanism of action. According to experimental studies, an increase in the local partial pressure of CO₂ is accompanied by improved tissue oxygenation, vasomotor responses, and a decrease in manifestations of hypoxia-induced damage. In addition, experimental studies have demonstrated the effect of CO₂ on the activation of angiogenesis, modification of cellular energy metabolism and regulation of the immunoinflammatory response. Analysis of available publications indicates that carboxytherapy can be considered an adjuvant treatment for the complex management of knee osteoarthritis. At the same time, at the current stage, the amount of evidence remains limited, which justifies the feasibility of conducting further clinical studies.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 18-26 pages, index UDC 616.72-002.77-08:615.5+615.832

DOI:

10.29254/2077-4214-2025-4-179-18-26