Pasiieshvili T. M.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. The aim of the study was to establish changes in some indicators of the immune system (caspase-1, interleukin-1β) and antioxidant defense system (total antioxidant activity, 8-isoprostane) in students with gastroesophageal reflux disease in conditions of autoimmune inflammation of the thyroid gland. 165 students took part in the work: 120 with combined course of gastroesophageal reflux disease and autoimmune thyroiditis and 45 with isolated gastroesophageal reflux disease. The mean age in the groups was 21.9 ± 2.7 and 21.2 ± 2.4 years, respectively. Control indicators of the research were obtained when examining 20 apparently healthy individuals of similar age, gender and social status. The content of caspase-1, interleukin-1β, total antioxidant activity, 8-isoprostane was determined in blood serum by enzyme immunoassay. The obtained results were processed using the licensed program Statistica Basic Academic 13 for Windows. The study showed that the active inflammatory process in the esophageal mucosa on the background of autoimmune inflammation in the thyroid gland is accompanied by a significant increase in the activity of caspase-1, interleukin-1β and 8-isoprostane and a decrease in total antioxidant activity. Dynamic observation of the activity of caspase-1, interleukin-1β and 8-isoprostane made it possible to establish their decrease, but the control indicators were not achieved. Thus, the exacerbation of the pathological process in patients with gastroesophageal reflux disease and the addition of autoimmune thyroiditis leads to the activation of the pro-inflammatory link of the immune system and the involvement of the oxidative defense system in the implementation of inflammation. At the same time, the clinical improvement of the patients’ condition does not lead to the normalization of these indicators, it can be both a consequence of the preservation of the autoimmune component of pathogenesis and oxidative stress. The data obtained became more significant in the joint course of pathologies.

gastroesophageal reflux disease, autoimmune thyroiditis, caspase-1, interleukin-1β, total antioxidant activity, 8-isoprostane.

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«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 105-108 pages, index UDK [616.329/.333-008.6:616.441-002]-053.81-092-078:57.083.3

10.29254/2077-4214-2021-1-159-105-108