Abstract. The problem of morpho-functional homeostasis in the thyroid gland in ontogenesis under the influence of various factors covers the issues of organ morphogenesis processes, compensatory-adaptive mechanisms, activity of proliferative processes. Consequence of the transferred infections of the pregnant woman can be initiation of morphological changes in organs and barrier structures of the fetus and the child, so infections directly do not lead to steady morpho-functional changes, but leave an immunological background in body and organism as a whole and initiate pathological conditions, including autoimmune diseases, etc. The aim: experimentally establish the features of morphological transformations of follicles and lymphoid tissue of the thyroid gland in the postnatal period of ontogenesis under the prenatal action of nonspecific forthyroid antigen – staphylococcal toxoid. The material of study was thyroid glands of Wistar rats aged 1 to 21 days of postnatal development (108 animals). Three groups of animals on 1, 3, 7, 11, 14, 21 days were studied: I group. – intact animals (norm); ІІ gr. – control, animals which were injected with 0.9% NaCl solution on the 18th day of the dated pregnancy; III – experimental animals injected with staphylococcal toxoid liquid purified adsorbed (10-14 units of binding in 1 ml, diluted 10 times) on the 18th day of the date of pregnancy operatively during laparotomy, by intrauterine, transdermal subcutaneous injection into the interscapular area at a dose of 0.05 ml of each fruit. Histological sections were stained byhematoxylin and eosin, according to the method of Van Gizon, immunohistochemically: used the proliferation marker ki-67 (Ki-67), CD3 (5B2) from Santa Cruz Biotechnology, Inc. At birth, experimental animals have more developed and mature structural elements of the thyroid gland. With the appearance of lymphocytic infiltration on the 3rd day of life and the formation of a lymphoid nodule on the 14th day, regenerative-desquamation processes increase, colloid resorption and active production of hormones in the bloodstream increase, as evidenced by follicles with highly vacuolated “foamy” colloid. Divergent folliculogenesis through the division of follicles and the emergence of interfollicular proliferating clusters, indicates a compensatory response to the appearance of follicles with signs of hypofunction and desquamation processes. Active morphogenetic changes in the thyroid gland of experimental animals are due of systemic prenatal antigenic influence of the body as a whole and it is a general reaction of the immune system before birth, which affects the immune status and morphogenesis of the body in the postnatal period. Compensatory-adaptive transformation of the thyroid gland into a polymorphoplastic variant with the formation of a lymphoid compartment may be a morphological basis for the development of autoimmune conditions of the thyroid gland and requires further detailed study, which is important for addressing issues of preventive and clinical medicine.
thyroid gland, antigen, morphogenesis, lymphocytes, proliferation.
«Bulletin of problems biology and medicine» Issue 2 (160), 2021 year, 245-249 pages, index UDK 612.44.014:616.441
