Kolinko L. M., Vesnina L. E.

PHYSIOLOGY

Scentific article

Overweight and obesity are among the most complex medical and social problems. Excess adipose tissue is associated with an increased risk and rapid development of cardiovascular diseases, and in particular among young adults. The aim of the study was to determine the functional state of the cardiovascular system in young people depending on the body weight. Ninety six participants of both sexes aged 18-25 were examined. Determined of height, body weight, waist circumference (WC) and thighs circumference (TC) and their ratio. Given the body mass index (BMI) they were divided into 3 groups: the control group included those with BMI 18.50-24.99 kg/m2 ; the group with the subjects having increased body weight with a BMI 25.00-29.99 kg/m2 , and the group of the subjects with class I obesity and BMI 30.00-34.99 kg/m2 . We determined indicators of heart rate, systolic and diastolic blood pressure at rest and following the exercise stress test, calculated pulse and mean hemodynamic pressure indicators, Robinson index. The results obtained were statistically processed. The study demonstrates a significant increase in the indicators reflecting the functional status of the cardiovascular system in the overweight participants and the individuals with the class I obesity at rest and after the exercise stress test that is confirmed with the mostly positive medium correlations between anthropometric indicators and functional activity indicators of the cardiovascular system in the individuals of the study groups. Significantly elevated Robinson’s index in the overweight male subjects and in the individuals of both sexes with class I obesity indicates a lack of functionality of the cardiovascular system, reduced energy metabolism and efficiency of the cardiovascular system. The resulting changes require physiological correction by modifying the lifestyle – reducing the caloric content of the diet and increasing the level of physical activity to prevent the intensification of pathological changes and the development of cardiovascular system diseases.

: anthropometric indicators, body mass index, overweight, class I obesity, cardiovascular system.

1. Chooi YC, Ding C, Magkos F. The epidemiology of obesity. Metabolism. 2019;92:6-10. DOI: 10.1016/j.metabol.2018.09.005
2. Parsanathan R, Sushil KJ. Novel invasive and noninvasive cardiac-specific biomarkers in obesity and cardiovascular diseases. Metab Syndr Relat Disord. 2020 Feb;18(1):10-30. DOI: 10.1089/met.2019.0073
3. Fox CS, Pencina MJ, Wilson PW, Paynter NP, Vasan RS, D’Agostino RB Sr. Lifetime risk of cardiovascular disease among individuals with and without diabetes stratified by obesity status in the Framingham heart study. Diabetes Care. 2008;31:1582-4. DOI: 10.2337/dc08-0025
4. Quinte GC, Barros F, Gigante DP, Oliveira IO, Santos Motta JV, Horta BL. Overweight trajectory and cardio metabolic risk factors in young adults. BMC Pediatr. 2019 Mar 11;19(1):75. DOI: 10.1186/s12887-019-1445-3
5. Mendis S, Puska P, Norrving B, editors. Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization. Geneva. 2011. s. 3-18.
6. Kolinko LM, Vesnina LE. Energy value of dietary intake and its conformity to daily needsin young people. Svit medytsyny ta biolohii. 2020;2(72):165-70. DOI: 10.26724/2079-8334-2020-2-72-165-170
7. Kolinko LM. Zminy kharchovoi povedinky u molodykh osib iz riznoi masoiu tila. Aktualni problemy suchasnoi medytsyny: Visnyk Ukrainskoi medychnoi stomatolohichnoi akademii. 2020;2(70):138-44. DOI: 10.31718/2077-1096.20.2.138 [in Ukrainian].
8. Martirosov EG, Nikolaiev DV, Rudniev SH. Tehnologii i metody opredeleniya sostava tela cheloveka. Moskva: Nauka; 2006. 247 s. [in Russiаn].
9. World Health Organization. Expert consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. The Lancet. 2004;363(9403):157-63. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14726171
10. World Health Organization. Physical status: the use and interpretation of anthropometry. Report of a WHO Expert Committee. World Health Organization. Technical Reports Series; 854. Geneva: World Health Organization. 1995. 463 p. Available from: http://helid.digicollection. org/en/d/Jh0211e/
11. Iakovliuk RM, Lukianchuk YuA. Problemy ta dosiahnennia pry vymiriuvanni arterialnoho tysku. Perspektyvni tekhnolohii ta prylady. 2014;4:114-8. Dostupno: http://nbuv.gov.ua/UJRN/ptp_2014_4_29 [in Ukrainian].
12. Kalmykova Y. Metody doslidzhennya u fizychniy reabilitatsiyi: doslidzhennya fizychnoho rozvytku. Kharkiv: 2014. 104 s. [in Ukrainian].
13. Savytskyi NN. Byofyzycheskye osnovі krovoobrashchenyia y klynycheskye metodі yzuchenyia hemodynamyky. 3-e yzd. yspr. y dop. Lenynhrad: Medytsyna; 1974. 312 s. [in Russiаn].
14. Marchyk VI, Minzhorina IL. Funktsionalni proby ta indeksy v doslidzhenni fizychnoho stanu liudyny: metodychni rekomendatsii. Kryvyi Rih: KPI DVNZ «KNU»; 2016. 64 s. Dostupno: http://elibrary.krpd.edu.ua/handle/0564/338 [in Ukrainian].
15. Marchyk VI. Metody doslidzhennia u fizychnomu vykhovanni: metodychni rekomendatsii. Kryvyi Rih: KDPU; 2018. 44 s. [in Ukrainian].
16. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA. 2014;311:507-20. DOI: 10.1001/jama.2013.284427
17. Osypov AS, Prokopev NIa, Romanova SV, Durov AM, Hubyn DH, Nazmutdynova VY, Fetysova EV. Srednee dynamycheskoe davlenye u muzhchyn peryoda pervoho zreloho vozrasta h. Tiumen pry lechenyy karyesa. Medytsynskaia nauka y obrazovanye Urala. 2016;4:106-10. [in Russiаn].
18. Tykhomyrova LM, Usoltsev AN, Husev AA. Funktsyonalnoe sostoianye serdechno-sosudystoi systemі u lyts molodoho vozrasta s umerenno vіrazhennoi arteryalnoi hypertenzyei. Kardyolohycheskyi zhurnal. 1988;28(3):66-9. [in Russiаn].
19. Baevskyi RM, Berseneva AP. Otsenka adaptatsyonnіkh vozmozhnostei orhanyzma y rysk razvytyia zabolevanyi. Moskva: Medytsyna; 1997. 236 s. [in Russiаn].
20. Yadav RL, Yadav PK, Yadav LK, Agrawal K, Sah SK, Islam MN. Association between obesity and heart rate variability indices: an intuition toward cardiac autonomic alteration – a risk of CVD. Diabetes Metab Syndr Obes Targets Ther. 2017;10:57-64.
21. Martins D, Tareen N, Pan D, Norris K. The relationship between body mass index, blood pressure, and pulse among normotensive and hypertensive participants in the third NHANES. Cell Mol Biol. 2003;49(8):1305-9.
22. Aghamohammadzadeh R, Heagerty AM. Obesity-related hypertension: Epidemiology, pathophysiology, treatments, and the contribution of perivascular adipose tissue. Annals of Medicine. 2012;44(1):74-84. DOI: 10.3109/07853890.2012.663928
23. Canoy D, Luben R, Welch A, Bingham S, Wareham N, Day N, et al. Fat distribution, body mass index and blood pressure in 22,090 men and women in the Norfolk cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Norfolk) study. Journal of Hypertension. 2004;22:2067-74.
24. Tuck ML, Sowers J, Dornfeld L, Kledzik G, Maxwell M. The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients. The New England Journal of Medicine. 1981;304:930-3. DOI: 10.1056/NEJM198104163041602
25. Hall JE, da Silva AA, do Carmo JM, Dubinion J, Hamza S, Munusamy S, et al. Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins. J Biol Chem. 2010;285:17271-6. DOI: 10.1074/jbc.R110.113175
26. de Faria APC, Ritter AMV, Gasparetti CS, Correa NB, Brunelli V, Almeida A, et al. A proposed inflammatory score of circulating cytokines/ adipokines associated with resistant hypertension, but dependent on obesity parameters. Arq Bras Cardiol. 2019;112(4):383-9. DOI: doi. org/10.5935/abc.20190032
27. Tadic M, Cuspidi C. Obesity and resistant hypertension: never ending story. J Clin Hypertens (Greenwich). 2019 Oct;21(10):1516-8. DOI: 10.1111/jch.13669
28. Rodrigues CIS. Biomarker-based Inflammatory Score in Obese Patients with Resistant Hypertension. Arq. Bras. Cardiol. 2019 Apr 15;112:1-2. DOI: doi.org/10.5935/abc.20190051
29. Noce A, Daniele ND. The «Weight» of Obesity on Arterial Hypertension. Medicine. 2019. Available from: http://dx.doi.org/10.5772/intechopen.87774
30. Sun K, Tordjman J, Clement K, Scherer PE. Fibrosis and adipose tissue dysfunction. Cell Metabolism. 2013;18:470-7. DOI: 10.1016/j. cmet.2013.06.016
31. Guzik TJ, Skiba DS, Touyz RM, Harrison DG. The role of infiltrating immune cells in dysfunctional adipose tissue. Cardiovascular Research. 2017;113:1009-23. DOI: 10.1093/cvr/cvx108
32. Kaydashev IP. Izmeneniye obraza zhizni, narusheniye energeticheskogo metabolizma i sistemnoye vospaleniye kak faktory razvitiya bolezney tsivilizatsii. Ukr. med. сhasopis. 2013;5(97):103-8. [in Russiаn].

«Bulletin of problems biology and medicine» Issue 4 (158), 2020 year, 389-394 pages, index UDK 616.1-053.81

10.29254/2077-4214-2020-4-158-389-394