Zolotukhina O. L., Romanova Iu. G.

DENTISTRY

Scentific article

Today, periodontal diseases remain an urgent problem of modern dentistry. Chronic generalized periodontitis (CHGP) is often combined with acid-dependent stomach diseases, such as chronic hyperacid gastritis, which is characterized by increased acidity of gastric juice. Smoking is also one of the important risk factors for periodontal disease, which complicates the course of both periodontitis and chronic gastritis. One of the main etiological factors of periodontal disease are dental plaque microorganisms. The state of imbalance in the system of oral cavity microbiocenosis is called the term «dysbiosis», which is characterized by an excess of opportunistic and pathogenic flora on the background of reduced or complete absence of normal microflora. Today, the prevalence of inflammatory periodontal disease determines the need to find and develop such new comprehensive tools for the treatment and prevention of periodontal disease. Moreover, of increasing interest are drugs of natural and herbal origin, which act gently, effectively and have fewer side effects, lower risk of allergic conditions. The aim of this work – to determine the features of periodontal pockets microbiocenosis in smoking patients with chronic generalized periodontitis on the background of chronic hyperacid gastritis before and after treatment. Object and methods. 14 smoking patients aged 25 to 44 years old with chronic generalized periodontitis and chronic hyperacid gastritis were studied. These patients were randomly divided into two groups depending on the chosen method of treatment: the 1st group – the use of basic therapy of CHGP and developed treatment prevention complex – TPC (ultraphonophoresis procedures with the created gel «Apisan» based on apiproducts and other biologically active substances and probiotic drug Linex forte; the 2nd group – the use of basic therapy of CHGP and ultraphonophoresis procedures with placebo. In our study, we analyzed the presence and quantitative content of the following periodontal pathogens: Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Porphyromonas gingivalis and Porphyromonas endodontalis by using the set «Dentoscreen Fluoropol-RV». The studies were performed with the voluntary informed consent of the patient before and after treatment.Results and discussion. Studies have shown that after the application of the developed TPC in patients of the 1st group significantly changes the species and quantitative composition of pathogens of periodontal pockets. In patients, the number and percentage of detection of periodontal pathogens – Tannerella forsythia, Porphyromonas endodontalis decreases. Complete elimination of pathogenic bacteria – Prevotella intermedia, Fusobacterium nucleatum and Porphyromonas gingivalis – was also achieved. The characteristics of periodontal pockets microbiocenosis in patients of the 2nd group, who underwent ultraphonophoresis with placebo during treatment, tend to increase quantitatively after treatment of pathogenic forms, due to the lack of antibacterial and probiotic action of the chosen treatment. Conclusion. The obtained results of PCR analysis after treatment allowed to establish the effectiveness of the TPC in smoking patients with CHGP of the initial, I degree on the background of acid-dependent stomach diseases. The TPC showed eliminating properties in relation to periodontopathogenic bacteria due to its constituent components, which allows us to recommend this TPC for use in the treatment of chronic generalized periodontitis of the initial, I degree.

periodontitis, periodontopathogens, gastritis, smoking.

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«Bulletin of problems biology and medicine» Issue 2 (156), 2020 year, 354-358 pages, index UDK 616.314.17-008.1:579.84: 616.31-085:613.84: 616.33-002.2

10.29254/2077-4214-2020-2-156-354-358