Hnatyuk M. S., Tatarchuk L. V., Cholach S. Yu., Stets N. Ya.
FEATURES OF AGE CHANGES OF THE SPATIAL CHARACTERISTICS OF HEART PARTS IN EXPERIMENTAL ANIMALS
Show/Download
About the author:
Hnatyuk M. S., Tatarchuk L. V., Cholach S. Yu., Stets N. Ya.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
Cardiovascular diseases are the most common, tend to increase, often lead to mortality and disability, and are a significant medical and social problem and the heart and blood vessels are still studied by morphologists and clinicians. The planimetric and volumetric parameters of the left and right ventricles and atria of 30 six-month-old male laboratory white rats and 30 similar animals aged 24 months were studied. Planimetry (area measurement) of the left and right ventricles' endocardial surface and left and right atria was performed. The planimetric and planimetric atrial index, left and right ventricular inflow, outflow and reserve volumes were determined. Quantitative morphological parameters were processed statistically. It was found that with age, the heart chambers unevenly disproportionately expanded, which was confirmed by an increase in the area of their endocardial surfaces. The unevenness and disproportionality of age-related expansion of the heart chambers was confirmed by changes in planimetric indices and atrial planimetric indices. Volumetric measurements revealed an age-related increase in the inflow and outflow volumes of the left and right ventricles and a decrease in their reserve volumes. In the left ventricle of 24-month-old white male rats, the reserve volume was reduced by 6.4% (p<0.001), in the right ventricle - by 4.1% (p<0.05). The studies and the results obtained indicate that with age, there is an uneven, disproportionate increase in the areas of the endocardial surfaces of the heart parts, as evidenced by changes in the planimetric index and the atrial planimetric index. The age-related increase in the supply and output and decrease in the reserve volumes of the ventricles were established. The most pronounced age-related decrease in reserve volume was found in the left ventricle.
Tags:
Bibliography:
- Akin I, Nienaber С. Prediction of aortic dissection. Heart. 2020;106(12):870-871.
- Amzulescu M, Slavich M, Florian A, Goetschalckx K. Does two-dimensional image reconstruction from three-dimensional full volume echocardiography improve the assessment of left ventricular morphology and function? Echocardiography. 2013;30:55-63.
- Kuzyk YuI. Features of the pathomorphological structure of the aterosclerotic plaques of carotid atherosclerosis. Pathologia. 2019;3:355- 361.
- Vlasiuk TI, Zhurakivska OY. Prospects for the use of exenatide in the correction of experimental diabetic cardiomyopathies. The Pharma Innovation Journal. 2018;7(9):35-40.
- Zuchi C, Tritto I, Carluccio E, Mattei C. Role of endothelial dysfunction in heart failure. Heart failure reviews. 2020;25(1):21-30.
- Mishalov VD, Tverdokhlib IV, Yurchenko VT. Pravove ta zakonodavche obhruntuvannia poriadku vyluchennia biolohichnykh obiektiv vid trupa liudyny dlia naukovykh doslidzhen z anatomii, histolohii, tsytolohii. Morphologia. 2016;10(1):107-110. [in Ukrainian].
- Hnatjuk MS, Gdanska NM, Tatarchuk LV, Monastyrska NYa. Morfometrychni aspekty vyvchennia prostorovykh zmin kamer sertsia pry rezektsii riznykh obiemiv parenkhimy pechinky. Visnyk problem biolohii i medytsyny. 2021;3:249-252. [in Ukrainian].
- Festing M, Nevalainen T. The design and statistical analysis of animal experiments introduction to this issue. Ilar J. 2014;55(3):379-372.
- Zaporozhan VM, Ariaiev ML. Bioetyka i biobezpeka. Kyiv: Zdorov҆ ia; 2013. 456 s. [in Ukrainian].
Publication of the article:
«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 395-400 pages, index UDC 616.36-089.87-06:616-091]-092.9
