Fishchenko V. O., Kylymniuk L. O., Kovalchuk V. M., Matsipura M. M., Renkas O. P.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Aim.To investigate the effects of extracorporeal shockwave therapy (ESWT) on bone healing process with unstable internal fixation by evaluating radiographic parameters in experimental conditions. Object and methods.An experimental study was performed on 40 healthy mongrel mature male rats weighing 330 ± 20 g. Under combined anesthesia, osteotomy of the diaphysis of the femoral bone was performed followed by intramedullary internal fixation. Among the operated 2 groups of rats were selected – experimental (n = 20) and control (n = 20). The rats of the experimental group additionally performed stimulation of fracture healing with ESWT. The complete course of treatment consisted of 4 sessions with intervals of 7 days. To assess the dynamics of regeneration of bone X-rays performed on the damaged segment at 14, 21, 28, 35 day of postoperative period. To quantify changes in radiographic parameters used radiographic evaluation of bone accretion of scale with modifications to one-bone segment. Results.At the 14 day, there was no significant difference in the radiographic regeneration parameters in the experimental group and in the control group. At the 21 day the remodeling process (p = 0.02), closing line of osteotomy (p = 0.04) and total results (p = 0.018) in experimental group of rats had significantly better results compared with those of the control group rats. At the 28 days the authentic difference in terms of the formation of callus (p = 0.01), closing line of osteotomy (p = 0.01), remodeling of bone tissue (p = 0.009) and total result (p = 0.01) in the study group. At the 35 day experimental group the fracture healing processes was significantly different compared with the control group in all parameters investigated (p = 0.01), an indicator of callus formation (p = 0.015), closing line of osteotomy (p = 0.019) and remodeling process (p = 0.019). In addition, the results of the study indicate that without the additional use of ESWT in an unstable internal fixation, the frequency of fracture increased (r = -0.5388, p≤0,05). Conclusion.The positive influence of the ESWT on the fracture healing, their dynamics and qualitative structure of bone tissue has been proved. The preventive effect of ESWT in formation of disorders of reparative regeneration in conditions of unstable internal fixation is established.

fracture healing, delay union, extracorporeal shockwave therapy

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«Bulletin of problems biology and medicine» Issue 1 Part 1 (142), 2018 year, 204-208 pages, index UDK 616.71-001.58:615.837:612.08

10.29254/2077-4214-2018-1-1-142-204-208