Shatorna V. F., Nefyodova O. O., Lomyha L. L., Zemlyany O. A., Kolosova I. I.

EXPERIMENTAL DETERMINATION OF CHANGES IN HEART MORPHOGENESIS UNDER THE INFLUENCE OF CADMIUM CHLORIDE IN ISOLATED ADMINISTRATION AND IN COMBINATION WITH SUCCINATES OF BIOGENIC METALS

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Shatorna V. F., Nefyodova O. O., Lomyha L. L., Zemlyany O. A., Kolosova I. I.

Heading:

MORPHOLOGY

Type of article:

Scientific article

Annotation:

This study is devoted to the investigation of structural transformations in the hearts of pregnant rats and their fetuses under the influence of a toxic factor, the widespread environmental pollutant cadmium chloride. The re search focused on the analysis of morphological and morphometric parameters of cardiac structures in experimental animals under conditions of prolonged exposure to cadmium chloride, as well as its combined administration with copper or zinc succinates. For the analysis, hearts of adult females and embryos (on the 13th and 20th days of devel opment) were used. A comprehensive approach that included histological examination and statistical analysis of the obtained data made it possible to trace in detail the features of cardiac morphogenesis under the influence of heavy metals. Particular attention was paid to the ability of zinc and copper to act as bioantagonists of cadmium-induced cardiotoxicity during prolonged exposure. Chronic administration of cadmium chloride (2 mg/kg) caused significant pathological changes manifested not only by an increase in embryonic mortality but also by specific alterations in cardiac development. The combination of cadmium with copper or zinc succinates significantly reduced its negative effects. These findings confirm the antitoxic properties of these compounds in counteracting cadmium-induced cardio- and embryotoxicity. It was demonstrated that the use of zinc succinate promotes the restoration of the histological structure of the myocardium damaged by cadmium exposure.

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Bibliography:

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Publication of the article:

«Bulletin of problems biology and medicine», 2026 Issue 1, 180, 467-478 pages, index UDC 611.12–053.13:546.48’131:546.461.4:616–091.8–092.9

DOI:

10.29254/2077-4214-2026-1-180-467-478