Kubrak M. A., Zavgorodnii S. M., Danyliuk M. B.

EVALUATION OF THE QUALITY OF LIFE OF PATIENTS AFTER SURGICAL INTERVENTIONS FOR COMPLICATED FORMS OF MALIGNANT DISEASES OF THE LARGE INTESTINE

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About the author:

Kubrak M. A., Zavgorodnii S. M., Danyliuk M. B.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The study aimed to analyse changes in the quality of life of patients who underwent surgery for complicated forms of colon cancer in the long-term postoperative period. The study included 180 (100%) patients who were treated for complicated colon cancer. All patients were divided into two groups. In the leading group, patients were treated according to a developed strategy of an individualised approach to treatment, while in the comparison group, they were treated according to standard methods to surgical treatment. The maximum deterioration in the quality of life of patients in both groups was observed in cases of colostomy – 35 (62.50%) and 14 (14.14%) patients, respectively. The deterioration in the quality of life of patients with colos tomy is due to a decrease in life activity, social functioning and role functioning, caused by emotional and physical conditions. Surgical interventions for complicated forms of colon cancer, which end in colostomy, significantly worsen the quality of life of patients due to their impact on both the mental (p=0.0147 in the main group and p=0.0338 in the comparison group) and physical components (p=0.0338 and p=0.0471, respectively). The use of a developed strategy of a comprehensive individualised approach to the treatment of complicated colon cancer allows for a reduction in the number of surgical interventions resulting in stoma formation (21.62% in the main group and 59.2% in the com parison group, p=0.0081), thereby improving the quality of life of patients in the postoperative period.

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Bibliography:

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. DOI: 10.3322/caac.21660.
2. Yang KM, Jeong MJ, Yoon KH, Jung YT, Kwak JY. Oncologic outcome of colon cancer with perforation and obstruction. BMC Gastroenterol. 2022;22(1):247. DOI: 10.1186/s12876-022-02319-5.
3.  Xu Z, Becerra AZ, Aquina CT, Hensley BJ, Justiniano CF, Boodry C, et al. Emergent Colectomy Is Independently Associated with Decreased Long-Term Overall Survival in Colon Cancer Patients. J Gastrointest Surg. 2017;21(3):543-553. DOI: 10.1007/s11605-017-3355-8.
4.  Biondo S, Gálvez A, Ramírez E, Frago R, Kreisler E. Emergency surgery for obstructing and perforated colon cancer: patterns of recurrence and prognostic factors. Tech Coloproctol. 2019;23(12):1141-1161. DOI: 10.1007/s10151-019-02110-x.
5.  Antony P, Harnoss JC, Warschkow R, Schmied BM, Schneider M, Tarantino I, et al. Urgent surgery in colon cancer has no impact on survival. J Surg Oncol. 2019;119(8):1170-1178. DOI: 10.1002/jso.25469.
6.  Li G, Qin R, Zhao X, Zhao D, Li P. Limitations on participation and global quality of life among CRC survivors with permanent stomas: moderated mediation analysis of psychological distress and family functioning. Support Care Cancer. 2023;31(9):526. DOI: 10.1007/s00520-023-07993-z.
7.  Ayaz-Alkaya S. Overview of psychosocial problems in individuals with stoma: A review of literature. Int Wound J. 2019;16(1):243-249. DOI:10.1111/iwj.13018.
8.  Alenezi A, McGrath I, Kimpton A, Livesay K. Quality of life among ostomy patients: A narrative literature review. J Clin Nurs. 2021;30(21-22):3111-3123. DOI: 10.1111/jocn.15840.
9. Kubrak MA, Zavgorodnyi SM, Danyliuk MB, Chemeris YuO. Comprehensive individualized approach to the treatment of patients with acuteintestinal obstruction of tumor genesis. The Ukrainian Journal of Clinical Surgery. 2025;92(1):27-30. DOI: 10.26779/2786-832X.2025.1.27.
10.  Kubrak MA, Zavhorodniy SM, Danylyuk MB. Osoblyvosti likuvannya khvorykh z uskladnenymy formamy raku tovstoho kyshkivnyka v umovakh zahalnoklinichnykh statsionariv. Klinichna khirurhiya. 2022;7-8(89):9-13. DOI: 10.26779/2522-1396.2022.7-8.09. [in Ukrainian].
11.  Fabregas JC, Ramnaraign B, George TJ. Clinical Updates for Colon Cancer Care in 2022. Clin Colorectal Cancer. 2022;21(3):198-203. DOI: 10.1016/j.clcc.2022.05.006.
12.  Krogsgaard M, Kristensen HØ, Furnée EJB, Verkuijl SJ, Rama NJ, Domingos H, et al. Life with a stoma across five European countries-across-sectional study on long-term rectal cancer survivors. Support Care Cancer. 2022;30(11):8969-8979. DOI: 10.1007/s00520-022-07293-y.
13.  Näsvall P, Dahlstrand U, Löwenmark T, Rutegård J, Gunnarsson U, Strigård K. Quality of life in patients with a permanent stoma after rectal cancer surgery. Qual Life Res. 2017;26(1):55-64. DOI: 10.1007/s11136-016-1367-6.
14.  Aluzaite K, Nuttall JW, O’Connor M, Harvie R, Schultz M. Quality of life in postostomy surgery patients: A cross-sectional survey. JGH Open. 2020;4(5):987-994. DOI: 10.1002/jgh3.12383.
15.  Lojo JJ, de la Villa R, Vega-Torres MM, Torres EA. Ostomy-Related Quality of Life in Puerto Ricans Living With Inflammatory Bowel Disease: A Prospective Cohort Study. J Wound Ostomy Continence Nurs. 2023;50(3):222-226. DOI: 10.1097/WON.0000000000000964.
16.  Ostovar S, Modarresi Chahardehi A, Mohd Hashim IH, Othman A, Kruk J, Griffiths MD. Prevalence of psychological distress among cancer patients in Southeast Asian countries: A systematic review. Eur J Cancer Care (Engl). 2022;31(6):e13669. DOI: 10.1111/ecc.13669.
17.  Ketterer SN, Leach MJ, Fraser C. Factors Associated With Quality of Life Among People Living With a Stoma in Nonmetropolitan Areas. Nurs Res. 2021;70(4):281-288. DOI: 10.1097/NNR.0000000000000511.

Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 190-198 pages, index UDC 616.345-006.6-06-085/-089-072.1

DOI:

10.29254/2077-4214-2025-2-177-190-198