Mamedova N. O.

ETIOLOGICAL FEATURES OF ISCHEMIC AND HEMORRHAGIC STROKES IN YOUNG PATIENTS

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About the author:

Mamedova N. O.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

The study investigated the etiological features of ischemic and hemorrhagic strokes in young patients aged 18 to 44 years. The results showed that among ischemic strokes in this group, the most frequent etiological subtypes were large artery atherosclerosis and other known causes. In the subgroup of women with ischemic stroke un related to pregnancy, cardiogenic etiology predominated. Meanwhile, in women with pregnancy-related stroke, other known causes were more commonly identified, including preeclampsia, hypercoagulability, and several rare diseases. Among patients older than 30 years, as well as in men, the primary cause of intracerebral hemorrhages was grade III arterial hypertension. Thus, the etiology of strokes in young patients demonstrates distinct age- and gender-related characteristics, necessitating an individualized approach to diagnosis and treatment. The findings emphasize the importance of comprehensive risk factor assessment and consideration of the specific conditions of pregnant women in the management of stroke patients.

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Bibliography:

1. Zhu W, Li X, Chen Y, Wang Z, Zhang H, Liu J, et al. Global and regional burden of ischemic stroke disease from 1990 to 2021: an age period-cohort analysis. Transl Stroke Res. 2024. DOI: 10.1007/s12975-024-01319-9.
2. Bukhari S, Yaghi S, Bashir Z, Smith J, Lee T, Johnson P, et al. Stroke in young adults. J Clin Med. 2023;12(15):4999. DOI: 10.3390/jcm12154999.
3. Greco A, Occhipinti G, Giacoppo D, Agnello F, Laudani C, Spagnolo M, et al. Antithrombotic therapy for primary and secondary prevention of ischemic stroke: JACC state-of-the-art review. J Am Coll Cardiol. 2023;82(15):1445-1464. DOI: 10.1016/j.jacc.2023.07.025.
4.  Goldemund D. TOAST classification of stroke. Brno: Stroke Manual; 2022. Available from: https://www.stroke-manual.com/toast-stroke-classification/.
5.  Campos A. ASCOD classification (Ischemic Stroke). 2024. Radiopaedia.org; Available from: https://radiopaedia.org/articles/ascod-classification-ischaemic-stroke.
6.  Özkaya A, Erdoğan HA, Acır İ, Çabalar M, Yayla V. The comparison of TOAST, CCS, and ASCO etiological classifications in ischemic stroke patients. Med J Bakirkoy. 2022;18(2):121-6.
7.  Mosconi MG, Paciaroni M, Agnelli G, Marzano M, Alberti A, Venti M, et al. SMASH-U classification: a tool for aetiology-oriented management of patients with acute haemorrhagic stroke. Intern Emerg Med. 2021;16(1):109-114. DOI: 10.1007/s11739-020-02330-2.
8.  Raposo N, Martinez-Majander N, Kaur G, Pera J, Smith E, Roberts H, et al. A causal classification system for intracerebral hemorrhage subtypes. Ann Neurol. 2022;93(1):16-28. DOI: 10.1002/ana.26519.
9.  Bukhari S, Yaghi S, Bashir Z. Stroke in young adults. J Clin Med. 2023;12(15):4999. DOI: 10.3390/jcm12154999.
10. Thomas Q, Dupont A, Martin L, Bernard S, Moreau P, Leroy C, et al. Stroke in women: when gender matters. Rev Neurol (Paris). 2021;177(8):881-889. DOI: 10.1016/j.neurol.2021.01.012.
11. Lee TH. Intracerebral hemorrhage. Cerebrovasc Dis Extra. 2024;15(1):1-8. DOI: 10.1159/000542566.
12.  Romano JG, Prabhakaran S, Nizam A, Feldmann E, Sangha R, Cotsonis G, et al. Infarct recurrence in intracranial atherosclerosis: results from the MyRIAD Study. J Stroke Cerebrovasc Dis. 2020;30(2):105504.
13.  Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. Classification of stroke subtypes. Cerebrovasc Dis. 2009;27(5):493-501. DOI: 10.1159/000210432.
14.  Jia Y, Li X, Wang J, Chen Y, Zhang L, Zhao Q, et al. SMASH-U aetiological classification: a predictor of long-term functional outcome after intracerebral haemorrhage. Eur J Neurol. 2022;29(1):178-187. DOI: 10.1111/ene.15111.
15.  Milicevic M, Krzesinski JM. Hypertension and the brain. Rev Med Liege. 2008;63(5-6):269-79.
16. Hayashi K, Naiki T. Adaptation and remodeling of vascular wall; biomechanical response to hypertension. J Mech Behav Biomed Mater.2009;2(1):3-19. DOI: 10.1016/j.jmbbm.2008.05.002.

Publication of the article:

«Bulletin of problems biology and medicine», Issue 2,177, 198-206 pages, index UDC 616. 831

DOI:

10.29254/2077-4214-2025-2-177-198-206