Khimion L., Sytiuk T., Danyliuk S., Yashchenko O., Kicha N.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Prevention and treatment of the NSAID-induced gastrointestinal damages could be difficult if patients have adverse events from proton pomp inhibitors (PPI) use. In such situation use of phyto complexes with defined and controlled components could be very useful. The aim of the study: to evaluate the safety and efficacy of the phyto complex Ultsenon in prevention and treatment of the non-ulcer NSAD-induced damages of the upper gastro-intestinal mucous in osteoarthritis (OA) patients. Object and methods. The study was conducted at Family Medicine Department of the Shupyk National Medical Academy of Postgraduate Education in 2 groups of patients who where prescribed NSAIDs for the treatment of OA exacerbation. The study group was consisted of 28 patients who had adverse events from previous PPI use, they were prescribed phyto complex Ultsenon, 400 mg 3 times a day; comparing group was consisted of 20 OA patients, who used omeprazole 20 mg daily during NSAID use. All patients consented to participate in all study procedures; underwent complex clinical (physical examination, quality of life evaluation (GSRS questionnaire), laboratory (hematology, ALT, AST) and instrumental (EGDS with biopsy) investigations. The complains, use of Ultsenon/ omeprazole and “rescue” medication (Gaviscon) was monitored with the help of patients dairy. Patients with the known active gastro-intestinal diseases (peptic ulcer, severe GERD, inflammatory bowel disease), other severe diseases, HIV were not included in the study. Results. The positive dynamic of gastro-intestinal symptoms (abdominal pain and discomfort, heartburn, vomiting, stool changes), GSRS points during the 28 days of the study showed no significant difference between groups of OA patients in case of erythematous and hemorrhagic gastroduodenitis, and was a bit faster in omeprazole group in case of erosive gastropathy (at day 2-3), but already without the difference at day 7 (5-8). There were no adverse events and no need in use of the rescue medication in both groups. Conclusion. Use of Ultsenon is effective and safe for the prevention of development/ progression and treatment of the non-ulcerous upper gastro-intestinal mucous damage during NSAID treatment in osteoarthrosis patients. Further clinical investigations are needed to determined efficacy of Ultsenon in treatment of other gastro-intestinal conditions.

NSAID-induced upper gastro-intestinal damages, Ultsenon, omeprazole, osteoarthritis.

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«Bulletin of problems biology and medicine» Issue 4 Part 2 (154), 2019 year, 230-238 pages, index UDK 616.1/9-056.76-07-08:614.2.07:066.1

10.29254/2077-4214-2019-4-2-154-230-238