Zavgorodnia N. G., Mykhailenko N. V., Bezugly M. B., Poplavska I. O.

CLINICAL AND EXPERIMENTAL MEDICINE

Scentific article

Abstract. High myopia is a common disorder worldwide. Highly myopic eyes tend to develop cataracts earlier than emmetropic or hypermetropic eyes. In parallel with myopia and cataract formation, there are changes in ocular hemo- and hydrodynamic parameters, and these processes mutually reinforce each other. Effect of phacoemulsification with intraocular lens (IOL) implantation on intraocular pressure and eye hydrodynamics may be consid-ered as sufficiently studied, however, changes of hemodynamic parameters remain unclear, especially in eyes with high myopia. This study included 58 patients (96 eyes) with high myopia and cataract aged 29-78 years (mean age 55.9±1.8). All patients had standard ophthalmologic examination (autorefractometry, visometry, perimetry, Amsler test, phosphene test, tonometry, biomicroscopy, direct ophthalmoscopy). Additional methods included Nesterov’s tonography (to evaluate true intraocular pressure (Ро), coefficient of outflow facility (C), rate of aqueous humor production (F) and Bekker coefficient (BC)) and doppler ultrasonography of ocular vessels (ophthalmic artery (OA), central retinal artery (CRA) and short posterior ciliary arteries (sPCA)) performed on a multifunctional ultrasound machine SonoAce-8000 Ex (Madison, South Korea). The following hemodynamic parameters were evaluated: peak systolic velocity Vps (sm/s), mean systolic velocity Vmed (sm/s) and variation in resistivity index (RI) of blood vessels. 6 months after phacoemulsification+IOL there was decrease of true intraocular pressure by 2.58 mmHg associated with elevated coefficient of outflow facility by 0.11 mm3 /min per 1 mmHg and elevated rate of aqueous humor production by 0.13 mm3 /min. The decrease was also observed in Bekker coefficient by 30.82 points indicating better trophic processes of the eye. The hemodynamic parameters changed too: during this period peak systolic velocity increased by 3.36 cm/sec in the ophthalmic artery, by 3.21 cm/sec in the central retinal artery, and by 2.25 cm/sec in short posterior ciliary arteries. After the surgery mean systolic velocity of the ophthalmic artery increased by 3.1 cm/sec, central retinal artery – by 2.01 cm/sec, short posterior ciliary arteries – by 2.98 cm/sec. 6 months after the surgery Ri decreased by 0.14 in the ophthalmic artery (0.48 ± 0,006 vs 0.34±0.006), by 0.14 in the central retinal artery (0.47 ± 0.007 vs 0.33±0.007) and by 0.13 in short posterior ciliary arteries (0.47±0.006 vs 0.34±0.006).

hydrodynamics of the eye, сataract, hemodynamics of the eye, high myopia.

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«Bulletin of problems biology and medicine» Issue 1 (159), 2021 year, 62-66 pages, index UDK 617.741-004.1-06:617.753.2]-089:617.7-005-008.8

10.29254/2077-4214-2021-1-159-62-66