Netyukhailo L. G., Avetikov D. S., Hasiuk Yu. A.

EFFECT OF QUERCETIN ON LIPID PEROXIDATION STATE IN EXPERIMENTAL CHEMICAL RHINITIS CAUSED BY ALKALINE BURN

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About the author:

Netyukhailo L. G., Avetikov D. S., Hasiuk Yu. A.

Heading:

CLINICAL AND EXPERIMENTAL MEDICINE

Type of article:

Scientific article

Annotation:

Treating inflammatory diseases of the nasal mucosa, particularly rhinitis, is one of the most pressing issues in medicine. Rhinitis is usually infectious and often seen in influenza and respiratory viral infections. This pathology can lead to dangerous complications, such as inflammation of the nasal cavity and paranasal sinuses, meningoencephalitis, brain abscess, and others. It is well known that inflammation is the basis for developing rhinitis. Inflammation involves several complex molecular reactions aimed at tissue repair and the fight against harmful factors. A significant amount of scientific research has been conducted to investigate the potential of antioxidants to prevent diseases that occur in the context of inflammation. However, the results have led to considerable uncertainty about the impact of antioxidants on inflammation. This prompted the need to study this issue as part of our work. In view of the above, there is a need to conduct studies using quercitin as a potential antioxidant agent. It will allow us to determine the effect of antioxidant properties on the course of the disease, particularly on the development of rhinitis. Quercitin, due to its antioxidant properties, protects the body from free radical damage and may be useful in treating various diseases. This study aimed to investigate the effect of quercetin on lipid peroxidation (LPO) during experimental chemical rhinitis. Chemical rhinitis was induced using a wet swab moistened with a 40% caustic soda solution inserted into each nostril. The drug is a bioflavianoid with the active ingredient quercetin. Assessment of the state of lipid peroxidation in the blood was performed by the following indicators: the content of diene conjugates (DC) - the initial products of lipid peroxidation, TBA-reagents. Indicators were studied in blood serum on the third and fourteenth days of the experiment.

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Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 1, 172, 209-215 pages, index UDC 616.211-092.11

DOI:

10.29254/2077-4214-2024-1-172-209-215