Kosharnyi V. V., Kahramanyan A. K.
DYNAMICS OF MORPHOMETRIC INDICATORS OF THE RAT KIDNEY AFTER EXPLOSION-INDUCED EXPERIMENTAL INJURY
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About the author:
Kosharnyi V. V., Kahramanyan A. K.
Heading:
MORPHOLOGY
Type of article:
Scientific article
Annotation:
Blast trauma is one of the most common and dangerous forms of mechanical injuries that can occur during combat operations, terrorist attacks, industrial accidents or other emergencies. The kidneys, as one of the key organs of the homeostasis system, play a crucial role in maintaining the physiological balance of the body, and their damage can lead to serious disorders, such as acute renal failure, electrolyte imbalance and intoxication. Thus, the study of the impact of blast trauma on the kidneys is extremely relevant, as it is aimed at improving the understanding of the pathogenesis of injuries, developing new methods of diagnosis and treatment, as well as reducing the risk of severe complications that threaten the lives of patients. The aim of the study was to investigate the features of the dynamics of morphometric indicators of renal corpuscles of the kidney after shock wave exposure in the acute, early and late periods in comparison with the control group. In our studies, it was found that under conditions of experimental exposure, significant morphometric changes in the renal corpuscle and glomerulus are observed. In the acute period, edema predominates, which leads to an increase in the diameters and area of the glomerulus. In the early period, the condition worsens due to tissue destruction, which is expressed in a decrease in the area of the glomerulus and an expansion of the space between the glomerulus and the capsule. In the late period, destructive processes progressed, but some indicators partially recovered, remaining higher than normal. These indicators are consistent with morphological changes in the structure of the nephron components, which were considered in our work.
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Bibliography:
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Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 1, 176, 436-443 pages, index UDC 612.46:616-001.31-007.23-092.9:534.222.2
