DIARRHOEAL SYNDROME: ALGORITHM OF EXAMINATION AND TACTICS OF PATIENT MANAGEMENT

Iziumska O. M., Koval T. I., Vatsenko A. I., Marchenko O. H., Poltorapavlov V. A., Pryimenko N. O., Bodnar V. A.

DIARRHOEAL SYNDROME: ALGORITHM OF EXAMINATION AND TACTICS OF PATIENT MANAGEMENT


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About the author:

Iziumska O. M., Koval T. I., Vatsenko A. I., Marchenko O. H., Poltorapavlov V. A., Pryimenko N. O., Bodnar V. A.

Heading:

LITERATURE REVIEWS

Type of article:

Scientific article

Annotation:

The article analyzes the current data on the diagnosis and treatment of diarrhoeal syndrome and proposes an algorithm for diagnostic search and tactics for managing a patient with acute infectious diarrhoea. General statistical information about the nature and prevalence of diseases associated with diarrhoea and adverse effects are presented. A modern definition of diarrhoea is given, and classification is provided by the course duration. The leading pathogenetic mechanism of development is presented. The article describes the primary syndromes in the clinic of infectious diarrhoea, particularly gastrointestinal tract lesions, dehydration and intoxication, which is necessary for a doctor to conduct a topical diagnosis, understand the severity of the disease and determine treatment tactics. The diagnostic search stages, which include a thorough general clinical examination of patients and the use of laboratory and instrumental research methods, are described in detail and, summarised and schematized in an algorithm. Attention is paid to the differential diagnosis of infectious and non-infectious genesis diarrhoea, primarily acute surgical and therapeutic conditions requiring different patient management tactics. A separate section is devoted to treating patients with diarrhoea of infectious origin, indications for hospitalization, and types of drug treatment. It is emphasized that rehydration is the cornerstone of treatment, symptomatic drugs are of limited interest, and antibiotics should be prescribed only in severe cases and in case of suspected invasive intestinal infections with enteropathogenic bacteria, as well as in patients at high risk of complications.

Tags:

algorithm, diagnosis, diarrhoeal syndrome, treatment

Bibliography:

  1. La Rocque R, Harris JB. Approach to the adult with acute diarrhea in resource-abundant settings. UpToDate; 2023. Available from: https:// www.uptodate. com/contents/approach-to-the-adult-with-acute-diarrhea-in-resource-limited-settings.
  2. World Health Organization. Diarrheal disease [Internet]. Geneva: WHO; 2024. Available from: https://www.who.int/news-room/fact-sheets/ detail/ diarrhoeal-disease.
  3. Simen-Kapeu A, Bogler L, Weber AC, Ntambi J, Zagre NM, Vollmer S, et al. Prevalence of diarrhoea, acute respiratory infections, and malaria over time (1995-2017): A regional analysis of 23 countries in West and Central Africa. J Glob Health. 2021;11:13008. DOI: 10.7189/ jogh.11.13008.
  4. Malysh N, Chemych M, Doan S, Rodyna R. Epidemiological characteristics of acute intestinal infection outbreaks in Ukraine Under the current conditions. Bangladesh J Med Sci. 2018;18(1):73-7. DOI: https://doi.org/10. 3329/bjms.v18i1.39552.
  5. Kotloff KL. Bacterial diarrhoea. Curr Opin Pediatr. 2022;34(2):147-55. DOI: https://doi.org/10.1097/mop.0000000000001107.
  6. Svintsitskyy AS, Gaevskyy P. Vnutrishni khvoroby: pidruchnik, zasnovaniy na principakh dokazovoi medycyny. Krakiv: Praktyczna medycyna; 2018. 1632 s. [in Ukrainian].
  7. Koval T, Izumska O, Dubinska G, Poltorapavlov V, Bodnar V, Kotelevska T, et al. Sindromna diagnostika v klinitsi infectsiynih hvorob. Lviv: «Magnolia 2006»; 2021 272 s. [in Ukrainian].
  8. Shane AL, Mody RK, Crump JA, Tarr PI, Steiner TS, Kotloff K, et al. 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea. Clin Infect Dis. 2017;65(12):e45-e80. DOI: 10.1093/cid/cix669.
  9. Jiang Z-D, DuPont HL. Etiology of travellers’ diarrhea. Journal of Travel Medicine. 2017;24(1):S13-6.
  10. Centers for Disease Control and Prevention. Travelers’ Diarrhea. CDC Yellow Book. Atlanta: CDC; 2024. Available from: https://wwwnc. cdc.gov/travel/yellowbook/2024/preparing/travelers-diarrhea.
  11. Chang H, Guo J, Wei Z, Huang Z, Wang C, Qiu Y, et al. Aetiology of acute diarrhoea in children in Shanghai, 2015-2018. PLoS One. 2021;16(4):e0249888. DOI: https://doi.org/10.1371/journal.pone.0249888.
  12. Kedir AY, Abel FD, Kibret GD, Bizuayehu H, Hassen TA, Amsalu E, et al. Population modifiable risk factors associated with under-5 acute respiratory tract infections and diarrhoea in 25 countries in sub-Saharan Africa (2014–2021): an analysis of data from demographic and health surveys. eClinicalMedicine. 2024;68:102444.
  13. Alberer M, Moe CL, Hatz C, Kling K, Kirby AE, Lindsay L, et al. Norovirus acute gastroenteritis amongst US and European travellers to areas of moderate to high risk of travellers’ diarrhoea: a prospective cohort study. Journal of Travel Medicine. 2024;31(7):taad051. DOI: https://doi.org/10.1093/jtm/ taad051.
  14. Golubovska OA, Andreychyn MA, Shcurba AV, Bodnia KI, Vasilieva NA, Gerasun BA, ta in. Infectsiyni khvoroby. Vyd 4, pererob. i dopov. Kiyiv: VSV «Medicina»; 2022. 464 s. [in Ukrainian].
  15. Centers for Disease Control and Prevention (CDC). Managing Acute Gastroenteritis Among Children: oral rehydration, maintenance, and nutritional therapy. Atlanta: CDC; 2003. 20 p. Available from: https://www.cdc.gov/mmwr/pdf/rr/rr5216.pdf.
  16. Dubinska G, Izumska O, Koval T, Poltorapavlov V, Bodnar V, Kotelevska T, et al. Zagalni printcipi obstegennia hvorih, algoritmi practichnih navichok ta nevidkladnoi dopomogi pri kritichnih stanah u klinitci infectsiynih hvorob. Chastyna 1. Poltava: Tehservis; 2016. 157 s. [in Ukrainian].
  17. Kotar T, Pirs M, Steyer A, Cerar T, Soba B, Skvarc M, et al. Evaluation of rectal swab use for the determination of enteric pathogens: a prospective study of diarrhoea in adults. Clin Microbiol Infect. 2019;25(6):733-738. DOI: 10.1016/j.cmi.2018.09.026.
  18. Jean S, Yarbrough ML, Anderson NW, Burnham CA. Culture of Rectal Swab Specimens for Enteric Bacterial Pathogens Decreases Time to Test Result While Preserving Assay Sensitivity Compared to Bulk Fecal Specimens. J Clin Microbiol 2019;57:e02077-18.
  19. Othma AAS, Gomaa HEE, El Anany MG, Rahman EM, Elbaky AMN, Soliman MMS, et al. Use of multiplex PCR in diagnosis of childhood acute viral diarrhoea caused by rotavirus, norovirus, astrovirus and adenovirus in Upper Egypt. Egypt J Med Hum Genet. 2022;23:40. DOI: https://doi.org/10.1186/s43042-022-00261-5.
  20. Binnicker MJ. Multiplex Molecular Panels for Diagnosis of Gastrointestinal Infection: Performance, Result Interpretation, and CostEffectiveness. J Clin Microbiol. 2015;53(12):3723-3728. DOI: 10.1128/JCM.02103-15.
  21. CDC. Guidelines for the management of acute diarrhea. Atlanta: CDC; 2005. 3 p. Available from: https://stacks.cdc.gov/view/cdc/25142.
  22. Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition/European Society for Pediatric Infectious Diseases evidence-based guidelines for the management of acute gastroenteritis in children in Europe: update 2014. J Pediatr Gastroenterol Nutr. 2014;59(1):132-152. DOI: 10.1097/MPG.0000000000000375.
  23. Lazzerini M, Sforzi I, Liguoro I, Felici E, Martelossi S, Bressan S, et al. Implementation of the WHO standards to assess the quality of care for children with acute diarrhoea: findings of a multicentre study (CHOICE) in Italy. BMJ Paediatrics Open. 2024;8:e002569. DOI: https:// dx.doi.org/10. 1136/bmjpo-2024-002569.
  24. Riddle MS, DuPont HL, Connor BA. ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults. Am J Gastroenterol. 2016;111(5):602-622. DOI: 10.1038/ajg.2016.126.
  25. Montero Moretón ÁM, Cabezudo Molleda L, García Castro MA, García Bravo M, Tinajas Puertas A, Santos Santamarta F, et al. Acute infectious diarrhoea and empirical antibiotic therapy sensitivity. Single-centre review. Gastroenterol Hepatol. 2022;45(1):117-118. Available from: https://pubmed. ncbi.nlm.nih.gov/34118315/.
  26. Kramarov SO, Zakordonets LV. Modern approaches to antibacterial therapy of acute intestinal infections. Actual infectology. 2018;6(3):119- 23. DOI: https://doi.org/10.22141/2312-413x.6.3.2018.136643.
  27. Libman M, CATMAT. Summary of the Committee to Advise on Tropical Medicine and Travel (CATMAT) Statement on Travellers' Diarrhea. Can Commun Dis Rep. 2015;41(11):272-284. DOI: 10.14745/ccdr.v41i11a03.
  28. Riddle MS, Connor BA, Beeching NJ, DuPont HL, Hamer DH, Kozarsky P, et al. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. J Travel Med. 2017;24(1):S57-S74. DOI: 10.1093/jtm/tax026.
  29. Chen K, Xin J, Zhang G, Xie H, Luo L, Yuan S, et al. A combination of three probiotic strains for treatment of acute diarrhoea in hospitalised children: an open label, randomised controlled trial. Beneficial Microbes. 2020;11(4):339-346. DOI: https://doi.org/10.3920/BM2020.0046.
  30. Shah M, Kathiiko C, Wada A, Odoyo E, Bundi M, Miring’u G, et al. Prevalence, seasonal variation, and antibiotic resistance pattern of enteric bacterial pathogens among hospitalized diarrheic children in suburban regions of central Kenya. Trop Med Health. 2016;44:39. DOI: 10.1186/s41182-016-0038-1.

Publication of the article:

«Bulletin of problems biology and medicine», 2024 Issue 4, 175, 32-45 pages, index UDC 616.34-008.314.4+616-08

DOI:

10.29254/2077-4214-2024-4-175-32-45

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