Ustimenko Ya. O., Lukyantseva H. V.
DEVELOPMENT OF A STUDY PROTOCOL FOR THE METABOLITE PROFILE AND MORPHOFUNCTIONAL PARAMETERS OF WOMEN WITH METABOLIC SYNDROME UNDER THE INFLUENCE OF COMBINED AND RESISTANCE TRAINING
Show/Download
About the author:
Ustimenko Ya. O., Lukyantseva H. V.
Heading:
SPORT MEDICINE
Type of article:
Scientific article
Annotation:
Metabolic syndrome is a complex disorder combining abdominal obesity, insulin resistance, dyslipidemia, and arterial hypertension, and represents a key predictor of cardiovascular diseases and type 2 diabetes mellitus. Despite numerous studies, standardized protocols for implementing combined and resistance training interventions in combination with diet therapy for individuals with this pathology are still lacking. This article is devoted to the development of a research protocol for the metabolite profile and morphofunctional parameters of women with metabolic syndrome under the influence of combined and resistance training. The aim of the study is to develop and test a protocol for a comprehensive study of the effects of combined and resistance training in combination with diet therapy on the serum metabolite profile and morphofunctional parameters of women with metabolic syndrome. Pilot testing of the protocol confirmed its practical feasibility and methodological coherence. All participants completed the initial assessment, and laboratory and anthropometric procedures were carried out without complications. Most participants adhered to the dietary recommendations, and home-based training programs did not cause significant diffi- culties. Recorded cases of irregular report submission indicate the need to improve the monitoring system. Changes in the structure of the protocol concerned mainly organizational components rather than the substantive content. The developed protocol is feasible under practical conditions and meets modern requirements for a comprehensive assessment of metabolic health. Its structure makes it possible to combine dietary and training interventions with biochemical monitoring without overburdening the participants. The results of the pilot phase create a basis for a full-scale interventional study.
Tags:
Bibliography:
- Fahed G, Aoun L, Bou Zerdan M, Allam S, Bou Zerdan M, Bouferraa Y, et al. Metabolic Syndrome: Updates on Pathophysiology and Management in 2021. Int J Mol Sci. 2022;23(2):786. DOI: 10.3390/ijms23020786.
- Dhondge RH, Agrawal S, Patil R, Kadu A, Kothari M. A Comprehensive Review of Metabolic Syndrome and Its Role in Cardiovascular Disease and Type 2 Diabetes Mellitus: Mechanisms, Risk Factors, and Management. Cureus. 2024;16(8):e67428. DOI: 10.7759/cureus.67428.
- Ding C, Yang Z, Wang S, Sun F, Zhan S. The associations of metabolic syndrome with incident hypertension, type 2 diabetes mellitus and chronic kidney disease: a cohort study. Endocrine. 2018;60(2):282-291. DOI: 10.1007/s12020-018-1552-1.
- Erdoğan K, Sanlier N. Metabolic Syndrome and Menopause: The Impact of Menopause Duration on Risk Factors and Components. Int J Womens Health. 2024;16:1249-1256. DOI: 10.2147/IJWH.S460645.
- Jeong HG, Park H. Metabolic Disorders in Menopause. Metabolites. 2022;12(10):954. DOI: 10.3390/metabo12100954.
- Kang SY, Lim GE, Kim YK, Kim HW, Lee K, Park TJ, et al. Association between Sarcopenic Obesity and Metabolic Syndrome in Postmenopausal Women: A Cross-sectional Study Based on the Korean National Health and Nutritional Examination Surveys from 2008 to 2011. J Bone Metab. 2017;24(1):9-14. DOI: 10.11005/jbm.2017.24.1.9.
- Silva FM, Duarte-Mendes P, Teixeira AM, Soares CM, Ferreira JP. The effects of combined exercise training on glucose metabolism and inflammatory markers in sedentary adults: a systematic review and meta-analysis. Sci Rep. 2024;14(1):1936. DOI: 10.1038/s41598-024-51832-y.
- Power S, Rowley N, Flynn D, Duncan M, Broom D. Home-based exercise for adults with overweight or obesity: A rapid review. Obes Res Clin Pract. 2022;16(2):97-105. DOI: 10.1016/j.orcp.2022.02.003.
- Bennett WC, Collins KA, Johnson JL, Slentz CA, Willis LH, Bales CW, et al. Effects of exercise amount and intensity versus a combined exercise and lifestyle intervention on metabolic syndrome in adults with prediabetes: a STRRIDE-PD randomized trial. Front Physiol. 2023;14:1199763. DOI: 10.3389/fphys.2023.1199763.
- Medvediev MO, Lukyantseva HV. Functional support of the liver, gallbladder, and pancreas: the potential of non-pharmacological interventions. Bulletin of problems in biology and medicine. 2025;3(178):76-87. DOI: 10.29254/2077-4214-2025-3-178-76-87.
- Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract. 2014;2014:943162. DOI: 10.1155/2014/943162.
- Westcott WL. Resistance training is medicine: effects of strength training on health. Curr Sports Med Rep. 2012;11(4):209-216. DOI: 10.1249/JSR. 0b013e31825dabb8.
- Su X, Peng D. Adipokines as novel biomarkers of cardio-metabolic disorders. Clin Chim Acta. 2020;507:31-38. DOI: 10.1016/j.cca.2020.04.009.
- Bae YJ, Kim SH, Chung JH, Song SW, Kim KS, Kim MK, et al. Evaluation of adiposity-related biomarkers as metabolic syndrome indicators. Clin Nutr Res. 2013;2(2):91-9. DOI: 10.7762/cnr.2013.2.2.91.
- Gasmi A, Mujawdiya PK, Noor S, Lysiuk R, Darmohray R, Piscopo S, et al. Polyphenols in Metabolic Diseases. Molecules. 2022;27(19):6280. DOI: 10.3390/molecules27196280.
- Guasch-Ferré M, Merino J, Sun Q, Fitó M, Salas-Salvadó J. Dietary Polyphenols, Mediterranean Diet, Prediabetes, and Type 2 Diabetes: A Narrative Review of the Evidence. Oxid Med Cell Longev. 2017;2017:6723931. DOI: 10.1155/2017/6723931.
- Haș IM, Teleky BE, Vodnar DC, Ștefănescu BE, Tit DM, Nițescu M. Polyphenols and Cardiometabolic Health: Knowledge and Concern among Romanian People. Nutrients. 2023;15(10):2281. DOI: 10.3390/nu15102281.
- Hughes RL, Alvarado DA, Swanson KS, Holscher HD. The Prebiotic Potential of Inulin-Type Fructans: A Systematic Review. Adv Nutr. 2022;13(2):492-529. DOI: 10.1093/advances/nmab119.
- Holscher HD. Dietary fiber and prebiotics and the gastrointestinal microbiota. Gut Microbes. 2017;8(2):172-184. DOI:10.1080/19490976.2017.1290756.
- Baptista NT, Dessalles R, Illner AK, Ville P, Ribet L, Anton PM, et al. Harnessing the power of resistant starch: a narrative review of its health impact and processing challenges. Front Nutr. 2024;11:1369950. DOI: 10.3389/fnut.2024.1369950.
- Munir H, Alam H, Nadeem MT, Almalki RS, Arshad MS, Suleria HAR. Green banana resistant starch: A promising potential as functional ingredient against certain maladies. Food Sci Nutr. 2024;12(6):3787-3805. DOI: 10.1002/fsn3.4063.
- Birt DF, Boylston T, Hendrich S, Jane JL, Hollis J, Li L, et al. Resistant Starch: Promise for Improving Human Health. Adv Nutr. 2013;4(6):587-601. DOI: 10.3945/an.113.004325.
- Strasser B, Schobersberger W. Evidence for resistance training as a treatment therapy in obesity. J Obes. 2011;2011:482564. DOI:10.1155/2011/482564.
- Schroeder EC, Franke WD, Sharp RL, Lee DC. Comparative effectiveness of home-based exercise training with and without wearable technology in overweight and obese adults: a systematic review. Sports Med. 2021;51(5):965-982. DOI: 10.1007/s40279-020-01405-4.
- Vaghetti CA, Botelho SS. Virtual learning environments in physical education: a systematic review. Sport TK. 2020;9(2):27-38. DOI:10.6018/sportk.431741.
- Garber CE, Blissmer B, Deschenes MR, Franklin BA, Lamonte MJ, Lee IM, et al. American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc. 2011;43(7):1334-1359. DOI: 10.1249/MSS.0b013e318213fefb.
- American College of Sports Medicine. ACSM’s Guidelines for Exercise Testing and Prescription. 10th ed. Alphen aan den Rijn: Wolters Kluwer; 2018. 472 р.
- Donnelly JE, Blair SN, Jakicic JM, Manore MM, Rankin JW, Smith BK, et al. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41(2):459-71. DOI: 10.1249/MSS.0b013e3181949333.
- Behm DG, Blazevich AJ, Kay AD, McHugh M. Acute effects of muscle stretching on physical performance, range of motion, and injury incidence in healthy active individuals: a systematic review. Appl Physiol Nutr Metab. 2016;41(1):1-11. DOI: 10.1139/apnm-2015-0235.
- Schoenfeld BJ, Grgic J, Van Every DW, Plotkin DL. Loading Recommendations for Muscle Strength, Hypertrophy, and Local Endurance: A Re-Examination of the Repetition Continuum. Sports (Basel). 2021;9(2):32. DOI: 10.3390/sports9020032.
- de Salles BF, Simão R, Miranda F, Novaes Jda S, Lemos A, Willardson JM. Rest interval between sets in strength training. Sports Med. 2009;39(9):765-777. DOI: 10.2165/11315230-000000000-00000.
- Bullard T, Ji M, An R, Trinh L, Mackenzie M, Mullen SP. A systematic review and meta-analysis of wearable technology and telephone support for physical activity and dietary intake. BMC Public Health. 2019;19(1):728. DOI: 10.1186/s12889-019-6987-7.
- Lewis BA, Williams DM, Neighbors CJ, Jakicic JM, Marcus BH. Cost analysis of Internet vs. print interventions for physical activity promotion. Psychol Sport Exerc. 2010;11(3):246-249. DOI: 10.1016/j.psychsport.2009. 10.002.
- Sorgente A, Cohen G, Fath K. A Systematic Review of Binge Eating, Loss of Control Eating, and Weight Management in Telehealth Interventions. Curr Obes Rep. 2023;12(2):121-32.
- Shapiro SS, Wilk MB. An analysis of variance test for normality (complete samples). Biometrika. 1965;52(3-4):591-611.
- Pallant J. SPSS Survival Manual: A Step by Step Guide to Data Analysis Using IBM SPSS. 7th ed. Oxfordshire: Routledge; 2020. 378 р.
Publication of the article:
«Bulletin of problems biology and medicine», 2025 Issue 4, 179, 397-406 pages, index UDC 612.1:612.015.3:615.825.1-055.2